细胞凋亡化合物库

Apoptosis Compound Library

产品编号： L9000

细胞凋亡是一种发生在多细胞生物中的程序性细胞死亡。相对于细胞坏死，细胞凋亡是受基因调控的主动过程，细胞凋亡时会发生特征性的形态学变化，产生称为凋亡小体的细胞碎片被吞噬细胞吞噬。细胞凋亡受到促凋亡因子(Fas 受体和 caspases)和抑凋亡因子(Bcl-2蛋白和 IAP)的调控，异常凋亡过程牵涉到多种疾病中，细胞凋亡的抑制可导致癌症、自身免疫性疾病、炎性疾病和病毒感染。另一方面，过度的细胞凋亡可能导致神经退行性疾病、血液疾病和组织损伤。目前在细胞凋亡与癌症发生和自身免疫性疾病之间的关系有着很多研究，人们希望激发癌细胞的细胞凋亡，以达到治疗癌症的目的。“细胞凋亡在神经退化性疾病中所扮演的角色（如阿兹海默氏症、亨丁顿舞蹈症、帕金森病、肌肉萎缩性侧索硬化症），是目前热门的研究领域。” TargetMol 细胞凋亡化合物库精选 2394 种与凋亡相关的生物活性小分子化合物，适用于癌症和神经退行性疾病相关研究。

陶术生物的所有产品和服务仅用于科学研究，我们不为任何个人用途提供产品和服务。

产品规格

技术资料

陶术生物化合物库目录(2.8MB)

库化合物信息

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产品描述

2394种与凋亡相关的生物活性小分子化合物的特有集合，多用于研究肿瘤发生发展机制和抗癌药物筛选等。可用于高通量筛选和高内涵筛选；
靶点含Bcl-2、Caspase、p53、TNF-α和survivin等；
通过前期临床研究和临床实验，生物活性和安全性已经得到验证；
其中一些活性化合物已得到FDA批准上市；
结构多样，药效显著，可渗透细胞；
详细的说明书，化合物结构、靶点信息、IC50值、活性描述等；
NMR和HPLC检测技术保证产品高纯度和高质量；
所有化合物现货供应。

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化合物库组成

Apoptosis (803)

Autophagy (222)

EGFR (66)

Ferroptosis (61)

CDK (59)

BCL (47)

TNF (47)

JAK (46)

VEGFR (43)

Raf (42)

HDAC (41)

Caspase (40)

FLT (39)

DNA/RNA Synthesis (38)

p53 (37)

Src (35)

PI3K (34)

RIP kinase (34)

c-RET (34)

p38 MAPK (29)

FGFR (29)

PDGFR (28)

Aurora Kinase (28)

COX (28)

MEK (28)

PERK (27)

Mdm2 (26)

mTOR (26)

c-Kit (26)

Microtubule Associated (26)

STAT (25)

ERK (24)

Bcr-Abl (24)

Epigenetic Reader Domain (24)

Antibacterial (24)

HSP (23)

E1/E2/E3 Enzyme (22)

Reactive Oxygen Species (22)

Akt (21)

NF-κB (21)

HIV Protease (20)

Histone Methyltransferase (20)

Ras (19)

Proteasome (18)

JNK (18)

Nucleoside Antimetabolite/Analog (18)

MAPK (18)

Antibiotic (18)

c-Met/HGFR (17)

Phosphatase (17)

PD-1/PD-L1 (17)

GSK-3 (16)

Tyrosine Kinases (16)

Pim (16)

PKC (16)

Dehydrogenase (15)

PARP (15)

HER (14)

Antioxidant (13)

Mitophagy (13)

IAP (13)

Mitochondrial Metabolism (13)

IL Receptor (13)

IGF-1R (13)

Sirtuin (13)

Endogenous Metabolite (13)

c-Myc (12)

Wnt/beta-catenin (12)

Serine/threonin kinase (12)

Topoisomerase (12)

Antifungal (11)

PPAR (11)

Parasite (11)

Chk (11)

DUB (11)

DNA-PK (10)

PDE (10)

Interleukin (10)

ALK (10)

IκB/IKK (10)

AMPK (10)

AChR (10)

Estrogen/progestogen Receptor (9)

DNA Alkylator/Crosslinker (9)

Histone Demethylase (9)

RAAS (9)

Histamine Receptor (9)

Rho (9)

Gamma-secretase (9)

Retinoid Receptor (9)

Potassium Channel (9)

S6 Kinase (9)

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PKA (8)

Cysteine Protease (8)

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ROS (8)

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ASK (8)

Casein Kinase (8)

Influenza Virus (8)

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PLK (8)

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Dopamine Receptor (7)

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BTK (7)

Lipoxygenase (7)

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Nrf2 (7)

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Integrin (6)

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TGF-beta/Smad (6)

Histone Acetyltransferase (6)

Kras (6)

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ATPase (5)

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Glutathione Peroxidase (5)

TRP/TRPV Channel (5)

HSV (5)

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Antiviral (5)

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HIF (5)

DAPK (5)

DNA Methyltransferase (5)

HCV Protease (4)

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MRP (4)

Serine Protease (4)

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CSF-1R (4)

Immunology/Inflammation related (4)

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CaMK (4)

DNA (4)

Telomerase (4)

OXPHOS (4)

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TLR (4)

Pyroptosis (4)

GPX (4)

HMG-CoA Reductase (4)

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MLK (4)

CRM1 (3)

YAP (3)

IFNAR (3)

DYRK (3)

Necroptosis (3)

Tie-2 (3)

TOPK (3)

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Leukotriene Receptor (3)

Glucokinase (3)

NAMPT (3)

MAO (3)

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DPP-4 (3)

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STING (3)

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GABA Receptor (3)

P450 (3)

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SGK (3)

NADPH-oxidase (3)

Sodium Channel (3)

Tyrosinase (3)

NOD-like Receptor (NLR) (3)

NO Synthase (3)

Proton pump (2)

Carbonic Anhydrase (2)

DHFR (2)

ROR (2)

ADC Cytotoxin (2)

LPL Receptor (2)

LTR (2)

Adenosine Receptor (2)

Reductase (2)

VDA (2)

Progesterone Receptor (2)

VDAC (2)

Antifolate (2)

Hck (2)

PYK2 (2)

FOXO1 (2)

iGluR (2)

Myosin (2)

IRE1 (2)

FLAP (2)

P2X Receptor (2)

Hexokinase (2)

Smo (2)

Endothelin Receptor (2)

KSP (2)

Wee1 (2)

Lipid (2)

Acyltransferase (2)

LRRK2 (2)

Free radical scavengers (2)

PAI-1 (2)

CRISPR/Cas9 (2)

Neurokinin receptor (2)

ROS Kinase (2)

Monoamine Oxidase (2)

Apelin receptor (1)

PROTACs (1)

NOS (1)

MALT (1)

Dynamin (1)

P2Y Receptor (1)

Na+/Ca2+ Exchanger (1)

GTPase (1)

GNRH Receptor (1)

cell cycle arrest (1)

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FXR (1)

SIK (1)

UGT (1)

MTH1 (1)

Fas/FasL (1)

NMDAR (1)

Guanylate cyclase (1)

Opioid Receptor (1)

APC (1)

Thioredoxin (1)

Stearoyl-CoA Desaturase (SCD) (1)

CCR (1)

CXCR (1)

Somatostatin (1)

PAD (1)

Xanthine Oxidase (1)

Epoxide Hydrolase (1)

ACK (1)

GluR (1)

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Indoleamine 2,3-Dioxygenase (IDO) (1)

PGE Synthase (1)

Glutathione reductase (1)

AChE (1)

P-gp (1)

Aminopeptidase (1)

AIM2 (1)

transporter (1)

Decarboxylase (1)

HuR (1)

MELK (1)

Hippo pathway (1)

Neprilysin (1)

GST (1)

Acetyl-CoA Carboxylase (1)

Protease (1)

LPA Receptor (1)

KLF (1)

PI4K (1)

GHSR (1)

Adenosine deaminase (1)

Cannabinoid Receptor (1)

Complement System (1)

BMI-1 (1)

NOD (1)

IRAK (1)

cholecystokinin (1)

Sigma receptor (1)

Thrombin (1)

Protease-activated Receptor (1)

p97 (1)

AhR (1)

Imidazoline Receptor (1)

化合物库信息示例

Empty	1000025-07-9	1000413-72-8	229005-80-5	1000787-75-6	946387-07-1	1000998-59-3	1175526-27-8	1001288-58-9	1001350-96-4	1001404-83-6	Empty
Empty	Vadadustat	TAK875	TAK-779	Tegobuvir	RN-1734	BMS-687453	AM211	FT011	BMS754807	AAI101	Empty
Empty	1001625-82-6	1001645-58-4	1001753-24-7	1001908-89-9	1002304-34-8	1002-84-2	100291-86-9	100299-08-9	10030-52-1	10040-45-6	Empty
Empty	RPW-24	SRT1720 hydrochloride	INH6	SRT 2183	AMG208	Pentadecanoic acid	Apiopaeonoside	Pemirolast potassium	L-Anserine nitrate salt	Sodium Picosulfate	Empty
Empty	100427-26-7	1004316-88-4	10045-45-1	100462-37-1	1004990-28-6	100-51-6	1005-24-9	1005264-47-0	1005334-57-5	1005342-46-0	Empty
Empty	Lercanidipine	Cobicistat	1-Ethyl-2-benzimidazolinone	ROSIRIDIN	PF-AKT400	Benzyl alcohol	1-Methylnicotinamide chloride	MX69	CVT-10216	LCL161	Empty
Empty	1005491-05-3	100-55-0	1005504-62-0	1005883-72-6	100643-71-8	1007207-67-1	10075-50-0	1007647-73-5	100784-20-1	10083-24-6	Empty
Empty	Tirasemtiv	Roniacol	Rg3039	Z433927330	Desloratadine	CH5132799	5-Bromoindole	Smurf1-IN-A01	Halosulfuron-methyl	Piceatannol	Empty
Empty	100872-83-1	100874-08-6	1009119-64-5	1009119-65-6	100929-71-3	1009298-09-2	1009298-59-2	100929-99-5	1009734-33-1	10097-84-4	Empty
Empty	ML346	SB 4	Daclatasvir	Daclatasvir dihydrochloride	NADPH (tetracyclohexanamine)	AZD8055	Vistusertib	PAβN dihydrochloride	HZ1157	Rotundine	Empty
Empty	1009816-48-1	1009817-63-3	1009820-21-6	100986-85-4	101001-34-7	1010411-21-8	1010-60-2	1011244-68-0	1011301-27-1	1011529-10-4	Empty
Empty	Thiamet G	B-AP15	Silmitasertib	Levofloxacin	Pamicogrel	GSK369796 Dihydrochloride	2-Chloronaphthoquinone	TFAP	Tenovin3	Azvudine	Empty
Empty	101152-94-7	101155-02-6	1011557-82-6	1011-74-1	101-20-2	1012054-59-9	101-21-3	101-26-8	101303-98-4	1013101-36-4	Empty
Empty	Milnacipran hydrochloride	BW-A78U	Tenovin-6	DL-Normetanephrine hydrochloride	Triclocarban	CUDC101	Chlorpropham	Mestinon	Zacopride hydrochloride	PF04691502	Empty
Empty	101-31-5	1013-69-0	1013750-77-0	1013753-99-5	10138-52-0	1013920-15-4	1013937-63-7	1014691-61-2	101477-54-7	101494-95-5	Empty
Empty	L-Hyoscyamine	Noreugenin	ML-030	BC-1382	Gadolinium chloride	Vorolanib	VTP-27999 TFA	GSK0660	Lomerizine hydrochloride	8-CHLOROQUINAZOLIN-4(1H)-ONE	Empty

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