抗纤维化化合物库

Anti-Fibrosis Compound Library

产品编号： L9810

纤维化（fibrosis）是一种病理改变，主要表现为器官组织内纤维结缔组织增多，实质细胞减少，持续进展可致器官结构破坏和功能减退，乃至衰竭，严重威胁人类健康和生命。纤维化可发生于多种器官，常见的包括肺脏、肝脏、肾脏、骨髓等。纤维化通常由各种刺激导致的慢性炎症性反应引起，包括：持续性感染，自身免疫反应，过敏性反应，化学刺激，射线和组织损伤等。

TargetMol 抗纤维化化合物库收集了1800 种潜在的抗纤维化分子，包括相关靶点如TGFβ、TNFα、MMP 的抑制剂、抗氧化剂及抗炎分子等，是研究纤维化机制和开发抗纤维化药物的良好工具。

陶术生物的所有产品和服务仅用于科学研究，我们不为任何个人用途提供产品和服务。

产品规格

技术资料

陶术生物化合物库目录(2.8MB)

库化合物信息

Excel

SDF

产品特性

1800种潜在的抗纤维化分子，是研究纤维化的有效工具，可以用于高通量筛选和高内涵筛选；
靶点包括TGFβ、TNFα、MMP、EGFR、NADPH-oxidase等；
部分化合物已经得到FDA批准上市；?
详细的说明书，化合物结构、靶点信息、IC50值、活性描述等；
NMR、HPLC/LCMS等多种检测技术保证产品结构正确，纯度高，减少假阳性。

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化合物库组成

Apoptosis (183)

Autophagy (164)

PI3K (126)

VEGFR (109)

PDGFR (91)

COX (80)

mTOR (69)

Raf (64)

Wnt/beta-catenin (61)

c-Kit (53)

Reactive Oxygen Species (52)

MMP (52)

TGF-beta/Smad (51)

GSK-3 (50)

CDK (45)

NF-κB (44)

FGFR (43)

p38 MAPK (42)

FLT (42)

Ras (41)

ERK (39)

Akt (39)

AMPK (36)

Src (35)

MEK (35)

IκB/IKK (34)

DNA-PK (33)

CFTR (26)

MAPK (24)

TNF (24)

JNK (23)

EGFR (23)

ALK (23)

ATM/ATR (22)

S6 Kinase (22)

Kras (20)

RIP kinase (19)

JAK (19)

Bcr-Abl (18)

Aurora Kinase (18)

Antibacterial (18)

Hedgehog/Smoothened (17)

c-RET (15)

Antibiotic (15)

c-Met/HGFR (14)

Antioxidant (14)

PDK (14)

Ferroptosis (12)

Mitophagy (12)

Rho (12)

PKC (11)

Endogenous Metabolite (11)

IRAK (11)

PKA (10)

Tyrosine Kinases (10)

Parasite (10)

PDE (10)

IL Receptor (10)

c-Fms (10)

NOD (10)

Calcium Channel (9)

ROCK (9)

Casein Kinase (9)

NOD-like Receptor (NLR) (9)

Mitochondrial Metabolism (8)

IGF-1R (8)

Interleukin (8)

Trk receptor (8)

PI4K (8)

Potassium Channel (8)

MLK (8)

Influenza Virus (7)

ROS (6)

Chk (6)

DNA/RNA Synthesis (6)

STAT (6)

FAK (6)

HER (6)

Dehydrogenase (5)

Antifungal (5)

PPAR (5)

Serine Protease (5)

SIK (5)

MNK (5)

Nrf2 (5)

Syk (5)

HIV Protease (4)

NADPH (4)

Tie-2 (4)

Glutathione Peroxidase (4)

TOPK (4)

Virus Protease (4)

CSF-1R (4)

E1/E2/E3 Enzyme (4)

Drug Metabolite (4)

BTK (4)

Smo (4)

Lipoxygenase (4)

Epigenetic Reader Domain (4)

Porcupine (4)

Free radical scavengers (4)

Ephrin Receptor (4)

ASK (4)

Ligand for E3 Ligase (4)

LPA Receptor (4)

ribosome (4)

AChR (4)

TAM Receptor (4)

Proteasome (3)

Chloride channel (3)

ATPase (3)

LPL Receptor (3)

RAAS (3)

Phosphatase (3)

c-Myc (3)

Caspase (3)

TRP/TRPV Channel (3)

Adrenergic Receptor (3)

Molecular Glues (3)

BCL (3)

PGE Synthase (3)

Antiviral (3)

HSP (3)

Prostaglandin Receptor (3)

SARS-CoV (3)

LRRK2 (3)

KLF (3)

GPR (3)

P450 (3)

PLK (3)

SGK (3)

p53 (3)

Monoamine Oxidase (3)

S1P Receptor (3)

Carbonic Anhydrase (2)

Transferase (2)

Histone Methyltransferase (2)

HCV Protease (2)

Integrin (2)

Estrogen/progestogen Receptor (2)

LTR (2)

Adenosine Receptor (2)

BACE (2)

GTPase (2)

MRP (2)

Serine/threonin kinase (2)

Cysteine Protease (2)

Glucocorticoid Receptor (2)

Immunology/Inflammation related (2)

Topoisomerase (2)

IRE1 (2)

DNA gyrase (2)

DNA Alkylation (2)

HSV (2)

CCR (2)

PTEN (2)

ACK (2)

Lipid (2)

MELK (2)

HDAC (2)

Phospholipase (2)

Gap Junction Protein (2)

Sodium Channel (2)

Mdm2 (1)

Proton pump (1)

Adenylyl cyclase (1)

PROTACs (1)

NOS (1)

GSNOR (1)

Monocarboxylate transporter (1)

YAP (1)

Reductase (1)

IFNAR (1)

DYRK (1)

Histone Demethylase (1)

Histamine Receptor (1)

Galectin (1)

ABC (1)

N-Acetylglucosaminyltransferase (1)

Estrogen Receptor/ERR (1)

Hck (1)

Leukotriene Receptor (1)

FXR (1)

PYK2 (1)

MAO (1)

Aryl Hydrocarbon Receptor (1)

IAP (1)

Myosin (1)

UGT (1)

Haspin Kinase (1)

Gamma-secretase (1)

LDL (1)

AAK1 (AP2 associated kinase 1) (1)

P2X Receptor (1)

Anion Exchanger (1)

Guanylate cyclase (1)

Fatty Acid Synthase (1)

FAAH (1)

Somatostatin (1)

cAMP (1)

CaMK (1)

DNA (1)

DUB (1)

Indoleamine 2,3-Dioxygenase (IDO) (1)

SGLT (1)

ATP Citrate Lyase (1)

OXPHOS (1)

Beta-Secretase (1)

AChE (1)

P-gp (1)

Acyltransferase (1)

STING (1)

Aminopeptidase (1)

Histone Acetyltransferase (1)

cGAS (1)

PAI-1 (1)

Methionine Adenosyltransferase (MAT) (1)

Hippo pathway (1)

GST (1)

Beta Amyloid (1)

GPX (1)

Retinoid Receptor (1)

CRISPR/Cas9 (1)

Hydroxylase (1)

Adenosine deaminase (1)

Discoidin Domain Receptor (DDR) (1)

NADPH-oxidase (1)

BMI-1 (1)

cholecystokinin (1)

Tyrosinase (1)

Microtubule Associated (1)

Thrombin (1)

PD-1/PD-L1 (1)

NO Synthase (1)

化合物库信息示例

Empty	1000025-07-9	1000413-72-8	229005-80-5	1000787-75-6	946387-07-1	1000998-59-3	1175526-27-8	1001288-58-9	1001350-96-4	1001404-83-6	Empty
Empty	Vadadustat	TAK875	TAK-779	Tegobuvir	RN-1734	BMS-687453	AM211	FT011	BMS754807	AAI101	Empty
Empty	1001625-82-6	1001645-58-4	1001753-24-7	1001908-89-9	1002304-34-8	1002-84-2	100291-86-9	100299-08-9	10030-52-1	10040-45-6	Empty
Empty	RPW-24	SRT1720 hydrochloride	INH6	SRT 2183	AMG208	Pentadecanoic acid	Apiopaeonoside	Pemirolast potassium	L-Anserine nitrate salt	Sodium Picosulfate	Empty
Empty	100427-26-7	1004316-88-4	10045-45-1	100462-37-1	1004990-28-6	100-51-6	1005-24-9	1005264-47-0	1005334-57-5	1005342-46-0	Empty
Empty	Lercanidipine	Cobicistat	1-Ethyl-2-benzimidazolinone	ROSIRIDIN	PF-AKT400	Benzyl alcohol	1-Methylnicotinamide chloride	MX69	CVT-10216	LCL161	Empty
Empty	1005491-05-3	100-55-0	1005504-62-0	1005883-72-6	100643-71-8	1007207-67-1	10075-50-0	1007647-73-5	100784-20-1	10083-24-6	Empty
Empty	Tirasemtiv	Roniacol	Rg3039	Z433927330	Desloratadine	CH5132799	5-Bromoindole	Smurf1-IN-A01	Halosulfuron-methyl	Piceatannol	Empty
Empty	100872-83-1	100874-08-6	1009119-64-5	1009119-65-6	100929-71-3	1009298-09-2	1009298-59-2	100929-99-5	1009734-33-1	10097-84-4	Empty
Empty	ML346	SB 4	Daclatasvir	Daclatasvir dihydrochloride	NADPH (tetracyclohexanamine)	AZD8055	Vistusertib	PAβN dihydrochloride	HZ1157	Rotundine	Empty
Empty	1009816-48-1	1009817-63-3	1009820-21-6	100986-85-4	101001-34-7	1010411-21-8	1010-60-2	1011244-68-0	1011301-27-1	1011529-10-4	Empty
Empty	Thiamet G	B-AP15	Silmitasertib	Levofloxacin	Pamicogrel	GSK369796 Dihydrochloride	2-Chloronaphthoquinone	TFAP	Tenovin3	Azvudine	Empty
Empty	101152-94-7	101155-02-6	1011557-82-6	1011-74-1	101-20-2	1012054-59-9	101-21-3	101-26-8	101303-98-4	1013101-36-4	Empty
Empty	Milnacipran hydrochloride	BW-A78U	Tenovin-6	DL-Normetanephrine hydrochloride	Triclocarban	CUDC101	Chlorpropham	Mestinon	Zacopride hydrochloride	PF04691502	Empty
Empty	101-31-5	1013-69-0	1013750-77-0	1013753-99-5	10138-52-0	1013920-15-4	1013937-63-7	1014691-61-2	101477-54-7	101494-95-5	Empty
Empty	L-Hyoscyamine	Noreugenin	ML-030	BC-1382	Gadolinium chloride	Vorolanib	VTP-27999 TFA	GSK0660	Lomerizine hydrochloride	8-CHLOROQUINAZOLIN-4(1H)-ONE	Empty

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