抗COVID-19中药单体库

Anti-COVID-19 Traditional Chinese Medicine Compound Library

产品编号： L6720

作为中华民族的瑰宝，从古到今，中医药对中国人民的生命、健康都起到了保驾护航的作用。在新型冠状病毒肆虐之时，从抗击疫情一线也不断传来中医药治疗该病的好消息。

中医药通过临床筛选出有效的方剂“三药三方”，发挥了重要的作用。“三药”即连花清瘟胶囊、金花清感颗粒、血必净注射液，这三个药物都是前期经过审批的已经上市的老药。“三方”是指清肺排毒汤、化湿败毒方、宣肺败毒方三个方剂。

连花清瘟胶囊在治疗轻型、普通型患者方面显示出良好的疗效，在缓解发热、咳嗽、乏力等症状方面疗效明显。同时，可以有效的减轻转重率。血必净注射液可以促进炎症因子的消除，主要用于重型和危重型患者的早期和中期治疗，可以提高治愈率、出院率，减少重型向危重型方面的转化几率。金花清感颗粒是2009年在抗击甲型H1N1流感中研发出的有效的中药。金花清感颗粒对治疗新冠肺炎的轻型、普通型患者疗效确切，可以缩短发热的时间，不仅能够提高淋巴细胞、白细胞的复常率，而且可以改善相关的免疫学指标。

研究证明，这些传统中药方剂通过多成分、多靶标起到整体调节作用，参与到免疫、抗炎、内分泌、信号传导等生物学过程，抑制细菌内毒素产生，起到平衡免疫、消除炎症的作用，避免或缓解炎症风暴。为了进一步研究中药方剂在新冠病毒治疗的作用机理，我们特提取出1147 种活性单体，希望通过现代医学和药学知识来探求抑制新冠病毒的机制机理。

本库中收集了对新冠病毒有明显作用的方剂中包含的金银花、连翘、黄芩、柴胡、藿香、板蓝根、红景天等60种中草药来源的单体化合物，组建抗COVID-19中药单体库，含黄酮、生物碱、多酚、萜类等多种结构类型，为抗新冠病毒药物研发助力！如果您正在从事新冠病毒相关研究，对中药疗法感兴趣，欢迎与我们联系~

陶术生物的所有产品和服务仅用于科学研究，我们不为任何个人用途提供产品和服务。

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产品描述

根据抗新冠肺炎疫情过程中应用于临床治疗的中药方剂，收集了1147种相关中药来源的单体化合物，可用于高通量和高内涵筛选，是抗新冠病毒药物研发的良好工具；
来源包括金银花、连翘、黄芩、柴胡、藿香、板蓝根、红景天等70种中草药；
结构多样，含黄酮、生物碱、多酚、萜类等多种结构类型；
NMR、HPLC/LCMS等多种检测技术保证产品结构正确，纯度高，减少假阳性。

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化合物库组成

Endogenous Metabolite (279)

Apoptosis (146)

Antibacterial (93)

Autophagy (91)

NF-κB (72)

Antioxidant (46)

Reactive Oxygen Species (45)

COX (45)

Antifungal (33)

Influenza Virus (33)

P450 (31)

Parasite (23)

Anti-infection (21)

TNF (20)

HIV Protease (18)

Virus Protease (18)

Calcium Channel (18)

NO Synthase (18)

GABA Receptor (18)

IL Receptor (17)

AChR (17)

p38 MAPK (16)

PPAR (16)

AChE (16)

Estrogen Receptor/ERR (15)

ERK (15)

MMP (15)

Ferroptosis (14)

DNA/RNA Synthesis (14)

Estrogen/progestogen Receptor (13)

Caspase (13)

ROS (13)

Akt (13)

Nrf2 (13)

TRP/TRPV Channel (12)

Beta Amyloid (12)

Antibiotic (12)

Tyrosinase (12)

PI3K (11)

Mitophagy (11)

STAT (11)

JNK (10)

Dehydrogenase (10)

5-HT Receptor (10)

PKC (8)

Immunology/Inflammation related (8)

HSV (8)

Lipoxygenase (8)

Antiviral (8)

AMPK (8)

RAAS (7)

PARP (7)

Adrenergic Receptor (7)

BCL (7)

EGFR (7)

Reductase (6)

MAO (6)

iGluR (6)

Mitochondrial Metabolism (6)

SARS-CoV (6)

NOS (5)

HCV Protease (5)

Wnt/beta-catenin (5)

Antifection (5)

Interleukin (5)

P-gp (5)

Prostaglandin Receptor (5)

BACE (4)

Phosphatase (4)

ATPase (4)

Dopamine Receptor (4)

HBV (4)

CDK (4)

Glucosidase (4)

Opioid Receptor (4)

Fatty Acid Synthase (4)

CXCR (4)

TGF-beta/Smad (4)

JAK (4)

IGF-1R (4)

mTOR (4)

MEK (4)

FGFR (4)

Potassium Channel (4)

HIF/HIF Prolyl-Hydroxylase (4)

p53 (4)

Monoamine Oxidase (4)

ROR (3)

GSK-3 (3)

Progesterone Receptor (3)

Proteasome (3)

Amino Acids and Derivatives (3)

UGT (3)

Drug Metabolite (3)

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MAPK (3)

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Src (2)

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Integrin (2)

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Serine Protease (2)

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cell cycle arrest (2)

Cysteine Protease (2)

Liver X Receptor (2)

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Aryl Hydrocarbon Receptor (2)

PAFR (2)

Gamma-secretase (2)

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Epigenetic Reader Domain (2)

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HSP (2)

Free radical scavengers (2)

Sirtuin (2)

PDGFR (2)

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Indoleamine 2,3-Dioxygenase (IDO) (2)

Telomerase (2)

Lipid (2)

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Histone Acetyltransferase (2)

HMG-CoA Reductase (2)

RSV (2)

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Sodium Channel (2)

S6 Kinase (2)

FAK (2)

Transaminase (1)

Monocarboxylate transporter (1)

stilbene oxidase (1)

CYP19A1 (1)

Dynamin (1)

Histamine Receptor (1)

Glutathione Peroxidase (1)

Melatonin Receptor (1)

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advanced glycation end products (1)

Proton pump (1)

Transferase (1)

NPC1L1 (1)

MyD88 (1)

IFNAR (1)

Lipase (1)

Factor Xa (1)

PKA (1)

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RANKL/RANK (1)

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PDE (1)

Fas/FasL (1)

LDL (1)

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Tyrosine Kinases (1)

Pim (1)

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E1/E2/E3 Enzyme (1)

MT Receptor (1)

DPP-4 (1)

Stearoyl-CoA Desaturase (SCD) (1)

Aurora Kinase (1)

GluR (1)

CaMK (1)

ATP Citrate Lyase (1)

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transporter (1)

Decarboxylase (1)

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PTEN (1)

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Pyroptosis (1)

ATM/ATR (1)

IRAK (1)

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ALK (1)

Casein Kinase (1)

Retinoid Receptor (1)

CRISPR/Cas9 (1)

GPR (1)

Platelet aggregation (1)

Syk (1)

DNA Methyltransferase (1)

NOD-like Receptor (NLR) (1)

Imidazoline Receptor (1)

HER (1)

化合物库信息示例

Empty	1000025-07-9	1000413-72-8	229005-80-5	1000787-75-6	946387-07-1	1000998-59-3	1175526-27-8	1001288-58-9	1001350-96-4	1001404-83-6	Empty
Empty	Vadadustat	TAK875	TAK-779	Tegobuvir	RN-1734	BMS-687453	AM211	FT011	BMS754807	AAI101	Empty
Empty	1001625-82-6	1001645-58-4	1001753-24-7	1001908-89-9	1002304-34-8	1002-84-2	100291-86-9	100299-08-9	10030-52-1	10040-45-6	Empty
Empty	RPW-24	SRT1720 hydrochloride	INH6	SRT 2183	AMG208	Pentadecanoic acid	Apiopaeonoside	Pemirolast potassium	L-Anserine nitrate salt	Sodium Picosulfate	Empty
Empty	100427-26-7	1004316-88-4	10045-45-1	100462-37-1	1004990-28-6	100-51-6	1005-24-9	1005264-47-0	1005334-57-5	1005342-46-0	Empty
Empty	Lercanidipine	Cobicistat	1-Ethyl-2-benzimidazolinone	ROSIRIDIN	PF-AKT400	Benzyl alcohol	1-Methylnicotinamide chloride	MX69	CVT-10216	LCL161	Empty
Empty	1005491-05-3	100-55-0	1005504-62-0	1005883-72-6	100643-71-8	1007207-67-1	10075-50-0	1007647-73-5	100784-20-1	10083-24-6	Empty
Empty	Tirasemtiv	Roniacol	Rg3039	Z433927330	Desloratadine	CH5132799	5-Bromoindole	Smurf1-IN-A01	Halosulfuron-methyl	Piceatannol	Empty
Empty	100872-83-1	100874-08-6	1009119-64-5	1009119-65-6	100929-71-3	1009298-09-2	1009298-59-2	100929-99-5	1009734-33-1	10097-84-4	Empty
Empty	ML346	SB 4	Daclatasvir	Daclatasvir dihydrochloride	NADPH (tetracyclohexanamine)	AZD8055	Vistusertib	PAβN dihydrochloride	HZ1157	Rotundine	Empty
Empty	1009816-48-1	1009817-63-3	1009820-21-6	100986-85-4	101001-34-7	1010411-21-8	1010-60-2	1011244-68-0	1011301-27-1	1011529-10-4	Empty
Empty	Thiamet G	B-AP15	Silmitasertib	Levofloxacin	Pamicogrel	GSK369796 Dihydrochloride	2-Chloronaphthoquinone	TFAP	Tenovin3	Azvudine	Empty
Empty	101152-94-7	101155-02-6	1011557-82-6	1011-74-1	101-20-2	1012054-59-9	101-21-3	101-26-8	101303-98-4	1013101-36-4	Empty
Empty	Milnacipran hydrochloride	BW-A78U	Tenovin-6	DL-Normetanephrine hydrochloride	Triclocarban	CUDC101	Chlorpropham	Mestinon	Zacopride hydrochloride	PF04691502	Empty
Empty	101-31-5	1013-69-0	1013750-77-0	1013753-99-5	10138-52-0	1013920-15-4	1013937-63-7	1014691-61-2	101477-54-7	101494-95-5	Empty
Empty	L-Hyoscyamine	Noreugenin	ML-030	BC-1382	Gadolinium chloride	Vorolanib	VTP-27999 TFA	GSK0660	Lomerizine hydrochloride	8-CHLOROQUINAZOLIN-4(1H)-ONE	Empty

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