抗癌药物库 | TargetMol

Anti-Cancer Drug Library

产品编号： L2150

尽管在过去的几十年中癌症的研究和治疗取得了巨大的成功，但癌症仍然是人类面临的巨大挑战，给患者身心健康带来巨大的痛苦。癌细胞具有许多显著不同的生物学特征，表现出无限的增殖潜能，维持自身生长信号的持续稳定，逃避应激信号诱导的细胞凋亡，刺激血管生长，为肿瘤提供营养，同时逃避免疫系统防御和诱导局部慢性炎症，发挥其侵袭和转移能力；并且表现出异常的代谢活动，并通过突变和表观遗传机制显著改变全基因组的稳定性。

我们挑选了3150 种具有抗癌活性或潜在抗癌活性的药物，包括上市和临床期药物，可用于具体癌症的阳性对照及不同癌症之间相关性研究，是您抗癌研究的有力工具！

陶术生物的所有产品和服务仅用于科学研究，我们不为任何个人用途提供产品和服务。

产品规格

技术资料

陶术生物化合物库目录(2.8MB)

库化合物信息

Excel

SDF

产品描述

3150个具有抗癌活性小分子的独特集合，生物活性已经临床前实验证实，可用于高通量、高内涵筛选；
所有化合物都具有已知且良好的生物活性、安全性和生物利用度，这些特性可显著加速药物开发和优化，是进行癌症相关研究和药物重定位有效的筛选工具；
作用靶点涉及PI3K、HDAC、mTOR、CDK、JAK 等癌症相关靶点，涉及的研究领域包括肺癌、乳腺癌、白血病、淋巴瘤等15种癌症；
结构多样，药效显著，可渗透细胞；
详细的说明书，化合物结构、靶点信息、IC50值、活性描述等；
NMR、HPLC/LCMS等多种检测技术保证产品结构正确，纯度高，减少假阳性。

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化合物库组成

Autophagy (436)

Apoptosis (421)

5-HT Receptor (198)

Endogenous Metabolite (174)

Adrenergic Receptor (168)

Antibacterial (146)

COX (133)

Dopamine Receptor (127)

Histamine Receptor (124)

Antibiotic (118)

DNA/RNA Synthesis (114)

Sodium Channel (96)

Calcium Channel (86)

VEGFR (84)

Potassium Channel (84)

EGFR (80)

AChR (73)

Parasite (68)

PI3K (66)

Glucocorticoid Receptor (61)

Reactive Oxygen Species (61)

P450 (59)

Topoisomerase (57)

CDK (56)

FLT (55)

HIV Protease (54)

NF-κB (53)

JAK (52)

PDGFR (52)

PPAR (51)

GABA Receptor (51)

c-Kit (49)

FGFR (48)

HDAC (46)

Microtubule Associated (44)

Estrogen/progestogen Receptor (43)

Ferroptosis (42)

Dehydrogenase (41)

Antifungal (41)

c-Met/HGFR (41)

Estrogen Receptor/ERR (41)

mTOR (41)

Prostaglandin Receptor (41)

Mitophagy (38)

Influenza Virus (36)

Src (35)

Nucleoside Antimetabolite/Analog (35)

Tyrosine Kinases (33)

Androgen Receptor (33)

SARS-CoV (33)

iGluR (32)

Bcr-Abl (32)

Adenosine Receptor (31)

PDE (30)

Raf (29)

GPR (29)

ADC Cytotoxin (28)

HER (26)

Serotonin Transporter (25)

TRP/TRPV Channel (25)

Akt (25)

ATPase (24)

PARP (24)

Opioid Receptor (24)

Norepinephrine (24)

Aurora Kinase (23)

HSP (22)

p38 MAPK (21)

Virus Protease (21)

PKC (21)

HSV (21)

Epigenetic Reader Domain (21)

P-gp (21)

ALK (21)

MEK (21)

TNF (21)

Proton pump (20)

NMDAR (20)

BTK (20)

DNA Alkylator/Crosslinker (19)

RAAS (19)

Phosphatase (18)

ERK (18)

ROS (18)

c-RET (18)

HIF/HIF Prolyl-Hydroxylase (18)

Histone Methyltransferase (17)

HBV (17)

Endothelin Receptor (17)

Trk receptor (17)

HCV Protease (16)

GSK-3 (16)

Drug Metabolite (16)

MMP (16)

AMPK (16)

Carbonic Anhydrase (15)

Progesterone Receptor (15)

Caspase (15)

BCL (15)

CXCR (15)

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STAT (15)

c-Fms (15)

Chk (14)

Retinoid Receptor (14)

TAM Receptor (14)

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DNA-PK (13)

GNRH Receptor (13)

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Guanylate cyclase (13)

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IL Receptor (13)

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p53 (13)

S1P Receptor (13)

LPL Receptor (12)

MAO (12)

P2X Receptor (12)

TGF-beta/Smad (12)

HIF (12)

CFTR (12)

Transferase (11)

DHFR (11)

MRP (11)

PKA (11)

Antifolate (11)

Gamma-secretase (11)

Mitochondrial Metabolism (11)

Hedgehog/Smoothened (11)

GluR (11)

Lipoxygenase (11)

IGF-1R (11)

Interleukin (11)

Neurokinin receptor (11)

HMG-CoA Reductase (11)

Monoamine Oxidase (11)

Antioxidant (10)

P2Y Receptor (10)

Wnt/beta-catenin (10)

ROCK (10)

IAP (10)

Vasopressin Receptor (10)

AChE (10)

TLR (10)

Nrf2 (10)

PLK (10)

Cannabinoid Receptor (10)

Syk (10)

ROS Kinase (10)

Mdm2 (9)

Chloride channel (9)

CSF-1R (9)

Indoleamine 2,3-Dioxygenase (IDO) (9)

ATM/ATR (9)

Beta Amyloid (9)

S6 Kinase (9)

NADPH (8)

JNK (8)

Antifection (8)

Smo (8)

CCR (8)

CaMK (8)

Antiviral (8)

Kras (8)

Phospholipase (8)

DNA Methyltransferase (8)

Sigma receptor (8)

Kinesin (8)

Integrin (7)

ABC (7)

Glucagon Receptor (7)

Monoamine Transporter (7)

OX Receptor (7)

DNA (7)

Sirtuin (7)

Casein Kinase (7)

Ligand for E3 Ligase (7)

Aromatase (7)

cholecystokinin (7)

Thrombin (7)

Histone Demethylase (6)

Glutathione Peroxidase (6)

Pim (6)

Leukotriene Receptor (6)

RIP kinase (6)

Isocitrate Dehydrogenase (IDH) (6)

PAK (6)

Bradykinin Receptor (6)

IκB/IKK (6)

IRAK (6)

NO Synthase (6)

IFNAR (5)

Tie-2 (5)

Serine Protease (5)

FXR (5)

Molecular Glues (5)

DPP-4 (5)

Fatty Acid Synthase (5)

PGE Synthase (5)

GPCR19 (5)

Ephrin Receptor (5)

GHSR (5)

Hydroxylase (5)

NOD (5)

Tyrosinase (5)

Amino Acids and Derivatives (4)

YAP (4)

LTR (4)

Melatonin Receptor (4)

CaSR (4)

Serine/threonin kinase (4)

Aryl Hydrocarbon Receptor (4)

IDO (4)

Annexin A (4)

DNA gyrase (4)

Neuropeptide Y Receptor (4)

Somatostatin (4)

Xanthine Oxidase (4)

KSP (4)

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STING (4)

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CRFR (4)

ribosome (4)

Melanocortin Receptor (4)

PDK (4)

Oxytocin Receptor (4)

CGRP Receptor (4)

Ras (4)

AhR (4)

PD-1/PD-L1 (4)

PROTACs (3)

NOS (3)

Monocarboxylate transporter (3)

ROR (3)

CRM1 (3)

Reductase (3)

Rho (3)

Cysteine Protease (3)

Liver X Receptor (3)

NAMPT (3)

PYK2 (3)

UGT (3)

MT Receptor (3)

Na-K-Cl cotransporter (3)

Hexokinase (3)

DUB (3)

PSMA (3)

MAPK (3)

OAT (3)

Free radical scavengers (3)

transporter (3)

RSV (3)

GST (3)

Adenosine deaminase (3)

Protease-activated Receptor (3)

NOD-like Receptor (NLR) (3)

CAT (2)

NEDD8 (2)

Ligands for Target Protein for PROTAC (2)

Arginase (2)

Cell wall (2)

PERK (2)

VDA (2)

Factor Xa (2)

Vitamin (2)

IRE1 (2)

LDL (2)

Glucosidase (2)

PROTAC Linker (2)

HCN Channel (2)

Telomerase (2)

ATP Citrate Lyase (2)

BCRP (2)

Beta-Secretase (2)

Acyltransferase (2)

Porcupine (2)

CD73 (2)

Decarboxylase (2)

Drug-Linker Conjugates for ADC (2)

LPA Receptor (2)

Gap Junction Protein (2)

Discoidin Domain Receptor (DDR) (2)

p97 (2)

MLK (2)

Imidazoline Receptor (2)

advanced glycation end products (1)

NPC1L1 (1)

Hydrogenase (1)

MALT (1)

BACE (1)

Na+/Ca2+ Exchanger (1)

DYRK (1)

RAR/RXR (1)

Lipase (1)

TOPK (1)

GTPase (1)

c-Myc (1)

Galectin (1)

Kisspeptin (1)

N-Acetylglucosaminyltransferase (1)

Hck (1)

Neurotensin Receptor (1)

Glucokinase (1)

Glutaminase (1)

Stemness kinase (1)

Immunology/Inflammation related (1)

Myosin (1)

Adiponectin receptor (1)

PAFR (1)

MTH1 (1)

GRK (1)

GlyT (1)

Anion Exchanger (1)

Thioredoxin (1)

FAAH (1)

PAD (1)

ACK (1)

cAMP (1)

Thrombopoietin Receptor (1)

Lipid (1)

Glutathione reductase (1)

MNK (1)

Survivin (1)

Histone Acetyltransferase (1)

ASK (1)

GluCls (1)

PAI-1 (1)

Pyroptosis (1)

MELK (1)

Methionine Adenosyltransferase (MAT) (1)

Hippo pathway (1)

Neprilysin (1)

PI4K (1)

KLF (1)

Aquaporin (1)

SGK (1)

Complement System (1)

Platelet aggregation (1)

NADPH-oxidase (1)

BMI-1 (1)

化合物库信息示例

Empty	1000025-07-9	1000413-72-8	229005-80-5	1000787-75-6	946387-07-1	1000998-59-3	1175526-27-8	1001288-58-9	1001350-96-4	1001404-83-6	Empty
Empty	Vadadustat	TAK875	TAK-779	Tegobuvir	RN-1734	BMS-687453	AM211	FT011	BMS754807	AAI101	Empty
Empty	1001625-82-6	1001645-58-4	1001753-24-7	1001908-89-9	1002304-34-8	1002-84-2	100291-86-9	100299-08-9	10030-52-1	10040-45-6	Empty
Empty	RPW-24	SRT1720 hydrochloride	INH6	SRT 2183	AMG208	Pentadecanoic acid	Apiopaeonoside	Pemirolast potassium	L-Anserine nitrate salt	Sodium Picosulfate	Empty
Empty	100427-26-7	1004316-88-4	10045-45-1	100462-37-1	1004990-28-6	100-51-6	1005-24-9	1005264-47-0	1005334-57-5	1005342-46-0	Empty
Empty	Lercanidipine	Cobicistat	1-Ethyl-2-benzimidazolinone	ROSIRIDIN	PF-AKT400	Benzyl alcohol	1-Methylnicotinamide chloride	MX69	CVT-10216	LCL161	Empty
Empty	1005491-05-3	100-55-0	1005504-62-0	1005883-72-6	100643-71-8	1007207-67-1	10075-50-0	1007647-73-5	100784-20-1	10083-24-6	Empty
Empty	Tirasemtiv	Roniacol	Rg3039	Z433927330	Desloratadine	CH5132799	5-Bromoindole	Smurf1-IN-A01	Halosulfuron-methyl	Piceatannol	Empty
Empty	100872-83-1	100874-08-6	1009119-64-5	1009119-65-6	100929-71-3	1009298-09-2	1009298-59-2	100929-99-5	1009734-33-1	10097-84-4	Empty
Empty	ML346	SB 4	Daclatasvir	Daclatasvir dihydrochloride	NADPH (tetracyclohexanamine)	AZD8055	Vistusertib	PAβN dihydrochloride	HZ1157	Rotundine	Empty
Empty	1009816-48-1	1009817-63-3	1009820-21-6	100986-85-4	101001-34-7	1010411-21-8	1010-60-2	1011244-68-0	1011301-27-1	1011529-10-4	Empty
Empty	Thiamet G	B-AP15	Silmitasertib	Levofloxacin	Pamicogrel	GSK369796 Dihydrochloride	2-Chloronaphthoquinone	TFAP	Tenovin3	Azvudine	Empty
Empty	101152-94-7	101155-02-6	1011557-82-6	1011-74-1	101-20-2	1012054-59-9	101-21-3	101-26-8	101303-98-4	1013101-36-4	Empty
Empty	Milnacipran hydrochloride	BW-A78U	Tenovin-6	DL-Normetanephrine hydrochloride	Triclocarban	CUDC101	Chlorpropham	Mestinon	Zacopride hydrochloride	PF04691502	Empty
Empty	101-31-5	1013-69-0	1013750-77-0	1013753-99-5	10138-52-0	1013920-15-4	1013937-63-7	1014691-61-2	101477-54-7	101494-95-5	Empty
Empty	L-Hyoscyamine	Noreugenin	ML-030	BC-1382	Gadolinium chloride	Vorolanib	VTP-27999 TFA	GSK0660	Lomerizine hydrochloride	8-CHLOROQUINAZOLIN-4(1H)-ONE	Empty

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