抗癌化合物库

Anti-Cancer Compound Library

产品编号： L2100

在过去的几十年中癌症的研究和治疗取得了巨大的成功，但癌症仍然是人类面临的巨大挑战，给患者身心健康带来巨大的痛苦。癌细胞具有许多显著不同的生物学特征，表现出无限的增殖潜能，维持自身生长信号的持续稳定，逃避应激信号(例如治疗药物)诱导的细胞凋亡，刺激血管生长，为肿瘤提供营养，同时逃避免疫系统防御和诱导局部慢性炎症，发挥其侵袭和转移能力，表现出异常的代谢活动，并通过突变和表观遗传机制显著改变全基因组的稳定性。

我们根据上述癌细胞显著不同的特征和异常的代谢活动，精心筛选了 8700 个肿瘤相关的小分子化合物，这些化合物都是调节肿瘤细胞代谢、增殖、侵袭、转移通路上的小分子，可用于肿瘤相关的研究以及抗肿瘤药物的筛选，可用于高通量、高内涵筛选。

陶术生物的所有产品和服务仅用于科学研究，我们不为任何个人用途提供产品和服务。

产品规格

技术资料

陶术生物化合物库目录(2.8MB)

库化合物信息

Excel

SDF

产品描述

8700种肿瘤相关的生物活性小分子化合物的特有集合，用于高通量、高内涵筛选；
产品经过临床验证和临床实验，具有生物安全保障和一定的生物活性；
是肿瘤发生机理研究、抗肿瘤药物筛选的有效工具；?
靶点含PI3K、HDAC、mTOR、CDK、Aurora Kinase、JAK等；
结构多样，药效显著，可渗透细胞；
详细的说明书，化合物结构、靶点信息、IC50值、活性描述等；
NMR、HPLC/LCMS检测技术保证产品高纯度和高质量，减少假阳性发生概率。

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化合物库组成

Apoptosis (1038)

Autophagy (706)

5-HT Receptor (356)

Endogenous Metabolite (335)

Antibacterial (286)

COX (269)

NF-κB (263)

Adrenergic Receptor (252)

DNA/RNA Synthesis (251)

CDK (227)

Dopamine Receptor (226)

PI3K (204)

EGFR (197)

Potassium Channel (186)

Reactive Oxygen Species (174)

Histamine Receptor (171)

Calcium Channel (171)

P450 (165)

VEGFR (164)

Antibiotic (160)

Sodium Channel (152)

JAK (133)

GABA Receptor (130)

HDAC (127)

Parasite (124)

PPAR (120)

TRP/TRPV Channel (120)

mTOR (115)

GPR (108)

AChR (107)

ERK (106)

Akt (106)

Antifungal (99)

Src (97)

Prostaglandin Receptor (97)

HIV Protease (96)

Wnt/beta-catenin (96)

FLT (93)

p38 MAPK (92)

Adenosine Receptor (92)

Estrogen Receptor/ERR (92)

Opioid Receptor (92)

PDGFR (90)

STAT (90)

PARP (86)

Microtubule Associated (84)

GSK-3 (83)

Nucleoside Antimetabolite/Analog (83)

AMPK (83)

Dehydrogenase (82)

Raf (82)

FGFR (81)

Caspase (79)

TNF (79)

Topoisomerase (78)

Estrogen/progestogen Receptor (77)

iGluR (77)

Influenza Virus (77)

Glucocorticoid Receptor (74)

BCL (73)

Epigenetic Reader Domain (72)

c-Kit (71)

c-Met/HGFR (70)

Androgen Receptor (68)

Antioxidant (66)

Cannabinoid Receptor (64)

Ferroptosis (63)

Bcr-Abl (63)

Histone Methyltransferase (62)

HSP (61)

PKC (60)

ATPase (59)

Sirtuin (58)

MMP (56)

TGF-beta/Smad (55)

IL Receptor (54)

Aurora Kinase (54)

Ras (54)

PDE (53)

ALK (53)

JNK (52)

MAPK (52)

Kras (52)

Phosphatase (51)

HER (51)

NO Synthase (50)

Tyrosine Kinases (48)

MEK (48)

Mitophagy (47)

P-gp (47)

ROCK (46)

DUB (45)

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ADC Cytotoxin (44)

p53 (44)

Serine/threonin kinase (43)

SARS-CoV (43)

Lipoxygenase (42)

NMDAR (41)

CXCR (41)

Virus Protease (40)

ROS (40)

HIF/HIF Prolyl-Hydroxylase (40)

DNA-PK (38)

S1P Receptor (38)

Neurokinin receptor (37)

P2X Receptor (36)

HSV (36)

IGF-1R (36)

LPL Receptor (35)

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PKA (34)

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Drug Metabolite (34)

Nrf2 (33)

NOD (33)

S6 Kinase (33)

RIP kinase (32)

BTK (32)

c-RET (32)

AChE (31)

HIF (31)

FAK (31)

NOS (30)

GluR (30)

ATM/ATR (30)

PLK (30)

Sigma receptor (30)

Serotonin Transporter (29)

Interleukin (29)

Antiviral (29)

Chloride channel (28)

Proton pump (28)

Casein Kinase (28)

TAM Receptor (28)

Proteasome (27)

HBV (27)

Mitochondrial Metabolism (27)

Norepinephrine (27)

Tyrosinase (27)

Chk (26)

TLR (26)

Trk receptor (26)

HCV Protease (25)

PERK (25)

Rho (25)

Gamma-secretase (25)

Phospholipase (25)

Protease-activated Receptor (25)

Mdm2 (24)

DNA Alkylator/Crosslinker (24)

Pim (24)

Endothelin Receptor (24)

Beta Amyloid (24)

Carbonic Anhydrase (23)

RAAS (23)

Neuropeptide Y Receptor (23)

IRAK (23)

Glucagon Receptor (22)

SGLT (22)

Retinoid Receptor (22)

PDK (22)

Syk (22)

P2Y Receptor (21)

Antifection (21)

Guanylate cyclase (21)

Bradykinin Receptor (20)

Melanocortin Receptor (20)

MAO (19)

Smo (19)

Reverse Transcriptase (19)

c-Fms (19)

Anti-infection (19)

DHFR (18)

DYRK (18)

c-Myc (18)

Fatty Acid Synthase (18)

cAMP (18)

DNA Methyltransferase (18)

cholecystokinin (18)

CFTR (18)

Transferase (17)

DNA Alkylation (17)

CCR (17)

OX Receptor (17)

transporter (17)

LPA Receptor (17)

PROTACs (16)

Histone Demethylase (16)

GNRH Receptor (16)

Vasopressin Receptor (16)

CaMK (16)

DNA (16)

PI4K (16)

ROS Kinase (16)

PD-1/PD-L1 (16)

Integrin (15)

NADPH (15)

GTPase (15)

Progesterone Receptor (15)

Antifolate (15)

Leukotriene Receptor (15)

IRE1 (15)

Monoamine Oxidase (15)

Kinesin (15)

ABC (14)

Neurotensin Receptor (14)

IAP (14)

Indoleamine 2,3-Dioxygenase (IDO) (14)

Histone Acetyltransferase (14)

NOD-like Receptor (NLR) (14)

Serine Protease (13)

Somatostatin (13)

GHSR (13)

YAP (12)

Reductase (12)

MRP (12)

Immunology/Inflammation related (12)

CSF-1R (12)

Aromatase (12)

HMG-CoA Reductase (12)

Monocarboxylate transporter (11)

CaSR (11)

Aryl Hydrocarbon Receptor (11)

GPCR19 (11)

Ligand for E3 Ligase (11)

Melatonin Receptor (10)

GRK (10)

AhR (10)

Glutathione Peroxidase (9)

FXR (9)

Monoamine Transporter (9)

Bombesin Receptor (9)

Telomerase (9)

BCRP (9)

Free radical scavengers (9)

Apelin receptor (8)

LTR (8)

BACE (8)

LIM Kinase (8)

Myosin (8)

PAK (8)

PGE Synthase (8)

STING (8)

Ephrin Receptor (8)

Thrombin (8)

Arrestin (7)

Na+/Ca2+ Exchanger (7)

IFNAR (7)

Tie-2 (7)

OCT (7)

Cysteine Protease (7)

Glucokinase (7)

SIK (7)

Annexin A (7)

UGT (7)

PAFR (7)

LDL (7)

Glucosidase (7)

Molecular Glues (7)

Isocitrate Dehydrogenase (IDH) (7)

PTEN (7)

Wee1 (7)

MNK (7)

Acyltransferase (7)

MLK (7)

Melanin-concentrating Hormone Receptor (MCHR) (6)

CRM1 (6)

Amino Acids and Derivatives (6)

Ligands for Target Protein for PROTAC (6)

Liver X Receptor (6)

PYK2 (6)

Glutaminase (6)

MT Receptor (6)

APC (6)

Lipid (6)

Beta-Secretase (6)

PSMA (6)

OAT (6)

Survivin (6)

CRFR (6)

MELK (6)

RSV (6)

GST (6)

GPX (6)

Hydroxylase (6)

cell cycle arrest (5)

NAMPT (5)

MTH1 (5)

DPP-4 (5)

FAAH (5)

ACK (5)

Porcupine (5)

LRRK2 (5)

ASK (5)

ribosome (5)

CRISPR/Cas9 (5)

Oxytocin Receptor (5)

CGRP Receptor (5)

SGK (5)

Platelet aggregation (5)

BMI-1 (5)

PKM (5)

NPC1L1 (4)

ROR (4)

TOPK (4)

Kisspeptin (4)

VDAC (4)

IDO (4)

Adiponectin receptor (4)

DNA gyrase (4)

Hexokinase (4)

PAD (4)

Xanthine Oxidase (4)

KSP (4)

ATP Citrate Lyase (4)

Aminopeptidase (4)

TSH Receptor (4)

PAI-1 (4)

Methionine Adenosyltransferase (MAT) (4)

Hippo pathway (4)

Aquaporin (4)

Adenosine deaminase (4)

Discoidin Domain Receptor (DDR) (4)

p97 (4)

Adenylyl cyclase (3)

RAR/RXR (3)

Factor Xa (3)

Galectin (3)

Hck (3)

RANKL/RANK (3)

Haspin Kinase (3)

AAK1 (AP2 associated kinase 1) (3)

Na-K-Cl cotransporter (3)

HCN Channel (3)

CD73 (3)

Decarboxylase (3)

Pyroptosis (3)

Carboxypeptidase (3)

KLF (3)

Complement System (3)

NADPH-oxidase (3)

Imidazoline Receptor (3)

CAT (2)

MALT (2)

EBI2/GPR183 (2)

NEDD8 (2)

MyD88 (2)

Arginase (2)

Sodium-dependent phosphate transporter (2)

Cell wall (2)

Lipase (2)

gp120/CD4 (2)

VDA (2)

Vitamin (2)

Epoxide Hydrolase (2)

OXPHOS (2)

Glutathione reductase (2)

AIM2 (2)

GluCls (2)

HuR (2)

Protease (2)

DAPK (2)

Gap Junction Protein (2)

lysosomal autophagy (2)

advanced glycation end products (1)

Transaminase (1)

Hydrogenase (1)

CD38 (1)

CYP19A1 (1)

NUDIX hydrolase (1)

Piezo Channel (1)

Dynamin (1)

Neuropeptide W (1)

Necroptosis (1)

N-Acetylglucosaminyltransferase (1)

Stemness kinase (1)

Amylase (1)

FLAP (1)

Phosphorylase (1)

GlyT (1)

Anion Exchanger (1)

Thioredoxin (1)

Stearoyl-CoA Desaturase (SCD) (1)

Angiotensin-converting Enzyme (ACE) (1)

Thrombopoietin Receptor (1)

cGAS (1)

hCE (1)

Neprilysin (1)

RXFP receptor (1)

化合物库信息示例

Empty	1000025-07-9	1000413-72-8	229005-80-5	1000787-75-6	946387-07-1	1000998-59-3	1175526-27-8	1001288-58-9	1001350-96-4	1001404-83-6	Empty
Empty	Vadadustat	TAK875	TAK-779	Tegobuvir	RN-1734	BMS-687453	AM211	FT011	BMS754807	AAI101	Empty
Empty	1001625-82-6	1001645-58-4	1001753-24-7	1001908-89-9	1002304-34-8	1002-84-2	100291-86-9	100299-08-9	10030-52-1	10040-45-6	Empty
Empty	RPW-24	SRT1720 hydrochloride	INH6	SRT 2183	AMG208	Pentadecanoic acid	Apiopaeonoside	Pemirolast potassium	L-Anserine nitrate salt	Sodium Picosulfate	Empty
Empty	100427-26-7	1004316-88-4	10045-45-1	100462-37-1	1004990-28-6	100-51-6	1005-24-9	1005264-47-0	1005334-57-5	1005342-46-0	Empty
Empty	Lercanidipine	Cobicistat	1-Ethyl-2-benzimidazolinone	ROSIRIDIN	PF-AKT400	Benzyl alcohol	1-Methylnicotinamide chloride	MX69	CVT-10216	LCL161	Empty
Empty	1005491-05-3	100-55-0	1005504-62-0	1005883-72-6	100643-71-8	1007207-67-1	10075-50-0	1007647-73-5	100784-20-1	10083-24-6	Empty
Empty	Tirasemtiv	Roniacol	Rg3039	Z433927330	Desloratadine	CH5132799	5-Bromoindole	Smurf1-IN-A01	Halosulfuron-methyl	Piceatannol	Empty
Empty	100872-83-1	100874-08-6	1009119-64-5	1009119-65-6	100929-71-3	1009298-09-2	1009298-59-2	100929-99-5	1009734-33-1	10097-84-4	Empty
Empty	ML346	SB 4	Daclatasvir	Daclatasvir dihydrochloride	NADPH (tetracyclohexanamine)	AZD8055	Vistusertib	PAβN dihydrochloride	HZ1157	Rotundine	Empty
Empty	1009816-48-1	1009817-63-3	1009820-21-6	100986-85-4	101001-34-7	1010411-21-8	1010-60-2	1011244-68-0	1011301-27-1	1011529-10-4	Empty
Empty	Thiamet G	B-AP15	Silmitasertib	Levofloxacin	Pamicogrel	GSK369796 Dihydrochloride	2-Chloronaphthoquinone	TFAP	Tenovin3	Azvudine	Empty
Empty	101152-94-7	101155-02-6	1011557-82-6	1011-74-1	101-20-2	1012054-59-9	101-21-3	101-26-8	101303-98-4	1013101-36-4	Empty
Empty	Milnacipran hydrochloride	BW-A78U	Tenovin-6	DL-Normetanephrine hydrochloride	Triclocarban	CUDC101	Chlorpropham	Mestinon	Zacopride hydrochloride	PF04691502	Empty
Empty	101-31-5	1013-69-0	1013750-77-0	1013753-99-5	10138-52-0	1013920-15-4	1013937-63-7	1014691-61-2	101477-54-7	101494-95-5	Empty
Empty	L-Hyoscyamine	Noreugenin	ML-030	BC-1382	Gadolinium chloride	Vorolanib	VTP-27999 TFA	GSK0660	Lomerizine hydrochloride	8-CHLOROQUINAZOLIN-4(1H)-ONE	Empty

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