抗癌上市药物库

Anti-Cancer Approved Drug Library

产品编号： L2110

尽管在过去的几十年中癌症的研究和治疗取得了巨大的成功，但癌症仍然是人类面临的巨大挑战，给患者身心健康带来巨大的痛苦。癌细胞具有许多显著不同的生物学特征，表现出无限的增殖潜能，维持自身生长信号的持续稳定，逃避应激信号诱导的细胞凋亡，刺激血管生长，为肿瘤提供营养，同时逃避免疫系统防御和诱导局部慢性炎症，发挥其侵袭和转移能力，表现出异常的代谢活动，并通过突变和表观遗传机制显著改变全基因组的稳定性。

根据文献报道和有关公开资料，我们挑选了1779 个具有抗癌活性或潜在抗癌活性的上市药物组成抗癌上市药物库，可用于具体癌症的阳性对照及不同癌症之间相关性研究。如果您对癌症相关适应症感兴趣，还可以关注我们其他三个库：抗癌分子库，癌细胞分化分子库，以及抗癌临床药物库。希望我们在抗癌研究的路上，助您一臂之力！

陶术生物的所有产品和服务仅用于科学研究，我们不为任何个人用途提供产品和服务。

产品规格

技术资料

陶术生物化合物库目录(2.8MB)

库化合物信息

Excel

SDF

产品描述

1779个具有抗癌活性小分子的独特集合，所有化合物都经过了严格的临床前研究和临床试验，由FDA、EMA或NMPA批准上市，可用于高通量、高内涵筛选。
所有化合物都具有已知且良好的生物活性、安全性和生物利用度，这些特性可显着加速药物开发和优化，是进行癌症相关研究和药物重定位有效的筛选工具。
作用靶点涉及PI3K、HDAC、mTOR、CDK、JAK 等癌症相关靶点，涉及的研究领域包括肺癌、乳腺癌、白血病、淋巴瘤等15种癌症;
结构多样，药效显著，可渗透细胞；
详细的说明书，化合物结构、靶点信息、IC50值、活性描述等；
NMR、HPLC/LCMS等多种检测技术保证产品结构正确，纯度高，减少假阳性。

化合物库定制

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化合物库咨询

化合物库组成

Autophagy (247)

Apoptosis (169)

Adrenergic Receptor (146)

5-HT Receptor (146)

COX (105)

Dopamine Receptor (99)

Histamine Receptor (99)

Antibacterial (96)

Antibiotic (77)

Sodium Channel (69)

Calcium Channel (63)

Potassium Channel (61)

DNA/RNA Synthesis (57)

AChR (53)

Glucocorticoid Receptor (47)

P450 (38)

Parasite (34)

VEGFR (32)

c-Kit (32)

HIV Protease (31)

PDGFR (30)

Antifungal (29)

EGFR (27)

Estrogen/progestogen Receptor (26)

PPAR (24)

GABA Receptor (24)

Estrogen Receptor/ERR (23)

Nucleoside Antimetabolite/Analog (23)

SARS-CoV (23)

Prostaglandin Receptor (22)

Endogenous Metabolite (22)

Ferroptosis (21)

Serotonin Transporter (21)

Norepinephrine (20)

Proton pump (19)

Mitophagy (19)

PDE (18)

FLT (18)

Src (17)

Dehydrogenase (17)

Topoisomerase (17)

JAK (17)

RAAS (16)

Bcr-Abl (16)

Androgen Receptor (16)

NF-κB (16)

FGFR (16)

ATPase (15)

DNA Alkylator/Crosslinker (15)

ADC Cytotoxin (14)

c-Met/HGFR (14)

HDAC (14)

Microtubule Associated (14)

Reactive Oxygen Species (13)

HSV (13)

Influenza Virus (13)

HBV (12)

Tyrosine Kinases (12)

iGluR (12)

ALK (12)

Progesterone Receptor (11)

GNRH Receptor (11)

PARP (11)

CDK (11)

Opioid Receptor (11)

SGLT (11)

Antifolate (10)

Raf (10)

c-RET (10)

Carbonic Anhydrase (9)

Virus Protease (9)

PKC (9)

MAO (9)

NMDAR (9)

P-gp (9)

Reverse Transcriptase (9)

Retinoid Receptor (9)

HER (9)

Proteasome (8)

DHFR (8)

HCV Protease (8)

P2Y Receptor (8)

Adenosine Receptor (8)

MRP (8)

TRP/TRPV Channel (8)

BTK (8)

ROS (8)

DNA Alkylation (8)

PI3K (7)

Phosphatase (7)

Drug Metabolite (7)

Antifection (7)

Guanylate cyclase (7)

CaMK (7)

Trk receptor (7)

MEK (7)

TAM Receptor (7)

Thrombin (7)

Monoamine Oxidase (7)

Hedgehog/Smoothened (6)

Kras (6)

Aromatase (6)

AMPK (6)

Phospholipase (6)

TNF (6)

Neurokinin receptor (6)

HMG-CoA Reductase (6)

ROS Kinase (6)

CFTR (6)

Chloride channel (5)

Histone Methyltransferase (5)

ABC (5)

ROCK (5)

ERK (5)

Monoamine Transporter (5)

IL Receptor (5)

Vasopressin Receptor (5)

Endothelin Receptor (5)

MMP (5)

GluR (5)

DNA (5)

mTOR (5)

Interleukin (5)

STAT (5)

DNA Methyltransferase (5)

S1P Receptor (5)

Transferase (4)

LPL Receptor (4)

NADPH (4)

CaSR (4)

Annexin A (4)

Smo (4)

DPP-4 (4)

Lipoxygenase (4)

PGE Synthase (4)

Antiviral (4)

TLR (4)

ribosome (4)

GPR (4)

HIF (4)

Sigma receptor (4)

HIF/HIF Prolyl-Hydroxylase (4)

NO Synthase (4)

Antioxidant (3)

Glutathione Peroxidase (3)

Melatonin Receptor (3)

PKA (3)

Serine Protease (3)

Serine/threonin kinase (3)

Cysteine Protease (3)

Leukotriene Receptor (3)

Caspase (3)

P2X Receptor (3)

Na-K-Cl cotransporter (3)

Mitochondrial Metabolism (3)

Molecular Glues (3)

Isocitrate Dehydrogenase (IDH) (3)

BCL (3)

Fatty Acid Synthase (3)

Xanthine Oxidase (3)

IGF-1R (3)

Akt (3)

AChE (3)

HSP (3)

Free radical scavengers (3)

Ligand for E3 Ligase (3)

c-Fms (3)

Melanocortin Receptor (3)

Oxytocin Receptor (3)

Hydroxylase (3)

Adenosine deaminase (3)

Syk (3)

FAK (3)

AhR (3)

NOS (2)

CAT (2)

Integrin (2)

CRM1 (2)

p38 MAPK (2)

Ligands for Target Protein for PROTAC (2)

YAP (2)

IFNAR (2)

GSK-3 (2)

Wnt/beta-catenin (2)

Rho (2)

FXR (2)

IRE1 (2)

Gamma-secretase (2)

MT Receptor (2)

Hexokinase (2)

Somatostatin (2)

Beta-Secretase (2)

MAPK (2)

OAT (2)

Ephrin Receptor (2)

Nrf2 (2)

RSV (2)

IκB/IKK (2)

GST (2)

Beta Amyloid (2)

GHSR (2)

CGRP Receptor (2)

Gap Junction Protein (2)

Ras (2)

cholecystokinin (2)

Tyrosinase (2)

Protease-activated Receptor (2)

Thyroid hormone receptor(THR) (1)

NPC1L1 (1)

Monocarboxylate transporter (1)

ROR (1)

Amino Acids and Derivatives (1)

LTR (1)

Reductase (1)

Na+/Ca2+ Exchanger (1)

RAR/RXR (1)

Histone Demethylase (1)

JNK (1)

TOPK (1)

VDA (1)

Hck (1)

Aryl Hydrocarbon Receptor (1)

CSF-1R (1)

Immunology/Inflammation related (1)

Adiponectin receptor (1)

UGT (1)

PAFR (1)

MTH1 (1)

LDL (1)

GRK (1)

Glucagon Receptor (1)

DNA gyrase (1)

PROTAC Linker (1)

HCN Channel (1)

PAK (1)

FAAH (1)

CCR (1)

Bradykinin Receptor (1)

CXCR (1)

Chk (1)

ACK (1)

Aurora Kinase (1)

cAMP (1)

Thrombopoietin Receptor (1)

Epigenetic Reader Domain (1)

DUB (1)

TGF-beta/Smad (1)

ATP Citrate Lyase (1)

Aminopeptidase (1)

GPCR19 (1)

Decarboxylase (1)

Pyroptosis (1)

Neprilysin (1)

PLK (1)

Complement System (1)

Cannabinoid Receptor (1)

NADPH-oxidase (1)

NOD (1)

S6 Kinase (1)

NOD-like Receptor (NLR) (1)

Imidazoline Receptor (1)

PD-1/PD-L1 (1)

化合物库信息示例

Empty	1000025-07-9	1000413-72-8	229005-80-5	1000787-75-6	946387-07-1	1000998-59-3	1175526-27-8	1001288-58-9	1001350-96-4	1001404-83-6	Empty
Empty	Vadadustat	TAK875	TAK-779	Tegobuvir	RN-1734	BMS-687453	AM211	FT011	BMS754807	AAI101	Empty
Empty	1001625-82-6	1001645-58-4	1001753-24-7	1001908-89-9	1002304-34-8	1002-84-2	100291-86-9	100299-08-9	10030-52-1	10040-45-6	Empty
Empty	RPW-24	SRT1720 hydrochloride	INH6	SRT 2183	AMG208	Pentadecanoic acid	Apiopaeonoside	Pemirolast potassium	L-Anserine nitrate salt	Sodium Picosulfate	Empty
Empty	100427-26-7	1004316-88-4	10045-45-1	100462-37-1	1004990-28-6	100-51-6	1005-24-9	1005264-47-0	1005334-57-5	1005342-46-0	Empty
Empty	Lercanidipine	Cobicistat	1-Ethyl-2-benzimidazolinone	ROSIRIDIN	PF-AKT400	Benzyl alcohol	1-Methylnicotinamide chloride	MX69	CVT-10216	LCL161	Empty
Empty	1005491-05-3	100-55-0	1005504-62-0	1005883-72-6	100643-71-8	1007207-67-1	10075-50-0	1007647-73-5	100784-20-1	10083-24-6	Empty
Empty	Tirasemtiv	Roniacol	Rg3039	Z433927330	Desloratadine	CH5132799	5-Bromoindole	Smurf1-IN-A01	Halosulfuron-methyl	Piceatannol	Empty
Empty	100872-83-1	100874-08-6	1009119-64-5	1009119-65-6	100929-71-3	1009298-09-2	1009298-59-2	100929-99-5	1009734-33-1	10097-84-4	Empty
Empty	ML346	SB 4	Daclatasvir	Daclatasvir dihydrochloride	NADPH (tetracyclohexanamine)	AZD8055	Vistusertib	PAβN dihydrochloride	HZ1157	Rotundine	Empty
Empty	1009816-48-1	1009817-63-3	1009820-21-6	100986-85-4	101001-34-7	1010411-21-8	1010-60-2	1011244-68-0	1011301-27-1	1011529-10-4	Empty
Empty	Thiamet G	B-AP15	Silmitasertib	Levofloxacin	Pamicogrel	GSK369796 Dihydrochloride	2-Chloronaphthoquinone	TFAP	Tenovin3	Azvudine	Empty
Empty	101152-94-7	101155-02-6	1011557-82-6	1011-74-1	101-20-2	1012054-59-9	101-21-3	101-26-8	101303-98-4	1013101-36-4	Empty
Empty	Milnacipran hydrochloride	BW-A78U	Tenovin-6	DL-Normetanephrine hydrochloride	Triclocarban	CUDC101	Chlorpropham	Mestinon	Zacopride hydrochloride	PF04691502	Empty
Empty	101-31-5	1013-69-0	1013750-77-0	1013753-99-5	10138-52-0	1013920-15-4	1013937-63-7	1014691-61-2	101477-54-7	101494-95-5	Empty
Empty	L-Hyoscyamine	Noreugenin	ML-030	BC-1382	Gadolinium chloride	Vorolanib	VTP-27999 TFA	GSK0660	Lomerizine hydrochloride	8-CHLOROQUINAZOLIN-4(1H)-ONE	Empty

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