抗乳腺癌化合物库

Anti-Breast Cancer Compound Library

产品编号： L2191

乳腺癌是乳腺恶性肿瘤，是全球女性发病率较高的癌症，约占女性癌症患者的20%，也是100多个国家癌症死亡的主要原因。近年来全球乳腺癌发病率一直呈上升趋势。乳腺癌根据病理分型可分为非浸润性癌，早期浸润性癌，浸润性癌。根据分子分型可分为雌激素受体阳性乳腺癌（ER+PR+HER2-），HER2阳性乳腺癌（ER-PR-HER2+），三阴性乳腺癌（ER-PR-HER2-）。不同类型的乳腺癌，从治疗方法到预后都是非常不同，需要针对已经明确的致癌位点，探索相关靶点来设计相应的药物。 TargetMol 抗乳腺癌库收集了2440 种与乳腺癌相关的化合物，包含了已经报道的有乳腺癌治疗作用的化合物，以及相关的靶点通路（HER-2, VEGF, EGFR, PARP, CDK4/6, HSP, PD-1, SET7/9, BRCA 等），是乳腺癌药物研发的良好工具。

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产品规格

技术资料

陶术生物化合物库目录(2.8MB)

库化合物信息

Excel

SDF

产品描述

2440种与乳腺癌相关的化合物，可以用于抗乳腺癌药物研发和药理研究；
靶点包含HER-2, VEGF, EGFR, PARP, CDK4/6, HSP, PD-1, SET7/9, BRCA等；
部分化合物已上市或已进入临床期；
详细的说明书，化合物结构、靶点信息、IC50值、活性描述等；
NMR、HPLC/LCMS等多种检测技术保证产品结构正确，纯度高，减少假阳性。

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化合物库组成

Apoptosis (276)

CDK (188)

Autophagy (184)

PI3K (174)

EGFR (173)

VEGFR (157)

mTOR (101)

HDAC (92)

COX (88)

PPAR (78)

GSK-3 (76)

NF-κB (76)

FGFR (76)

PARP (73)

PDGFR (67)

Akt (65)

HSP (60)

Reactive Oxygen Species (59)

TGF-beta/Smad (53)

AMPK (51)

c-Kit (46)

FLT (45)

Src (42)

DNA-PK (38)

Estrogen/progestogen Receptor (37)

IκB/IKK (35)

HER (34)

Estrogen Receptor/ERR (33)

S6 Kinase (29)

ATM/ATR (27)

Progesterone Receptor (24)

RIP kinase (24)

Aurora Kinase (24)

ALK (24)

c-Met/HGFR (22)

Wnt/beta-catenin (22)

DNA/RNA Synthesis (21)

Ferroptosis (20)

ERK (20)

Bcr-Abl (20)

PD-1/PD-L1 (20)

PDK (19)

c-RET (19)

Raf (18)

Endogenous Metabolite (18)

PKC (17)

Gamma-secretase (17)

Antibacterial (17)

Microtubule Associated (17)

JAK (16)

IRAK (16)

PI4K (15)

IGF-1R (14)

Mitophagy (13)

PKA (13)

Chk (13)

Potassium Channel (13)

NOD (13)

Parasite (12)

MAPK (12)

TAM Receptor (12)

Antibiotic (12)

Dehydrogenase (11)

Calcium Channel (11)

Epigenetic Reader Domain (11)

Casein Kinase (11)

STAT (11)

MEK (11)

IL Receptor (10)

c-Fms (10)

TNF (10)

HIV Protease (9)

Phosphatase (9)

Tyrosine Kinases (9)

Topoisomerase (9)

Trk receptor (9)

P450 (9)

FAK (9)

NOD-like Receptor (NLR) (9)

SIK (8)

Prostaglandin Receptor (8)

Aromatase (8)

PROTACs (7)

Antioxidant (7)

JNK (7)

TRP/TRPV Channel (7)

ROCK (7)

Drug Metabolite (7)

BTK (7)

Interleukin (7)

Sirtuin (7)

Ras (7)

p53 (7)

ADC Cytotoxin (6)

p38 MAPK (6)

DYRK (6)

Histone Demethylase (6)

Nucleoside Antimetabolite/Analog (6)

PDE (6)

Mitochondrial Metabolism (6)

ROS (6)

Androgen Receptor (6)

MELK (6)

Influenza Virus (6)

Beta Amyloid (6)

PLK (6)

Proteasome (5)

Carbonic Anhydrase (5)

Histone Methyltransferase (5)

HCV Protease (5)

Antifungal (5)

NADPH (5)

Virus Protease (5)

Pim (5)

Serine/threonin kinase (5)

GPR (5)

SGK (5)

Syk (5)

Tyrosinase (5)

Tie-2 (4)

Rho (4)

Serine Protease (4)

Caspase (4)

Adrenergic Receptor (4)

Glucocorticoid Receptor (4)

CSF-1R (4)

E1/E2/E3 Enzyme (4)

BCL (4)

Fatty Acid Synthase (4)

HSV (4)

MMP (4)

Lipoxygenase (4)

Antiviral (4)

TLR (4)

Ephrin Receptor (4)

Sodium Channel (4)

DHFR (3)

Adenosine Receptor (3)

Histamine Receptor (3)

GTPase (3)

PYK2 (3)

Aryl Hydrocarbon Receptor (3)

MAO (3)

IRE1 (3)

DNA Alkylation (3)

CaMK (3)

DUB (3)

Wee1 (3)

PGE Synthase (3)

Survivin (3)

SARS-CoV (3)

LRRK2 (3)

Nrf2 (3)

HIF (3)

MLK (3)

Kinesin (3)

Chloride channel (2)

YAP (2)

DNA Alkylator/Crosslinker (2)

LTR (2)

IFNAR (2)

PERK (2)

RAAS (2)

Glutathione Peroxidase (2)

TOPK (2)

c-Myc (2)

ABC (2)

GNRH Receptor (2)

Hck (2)

Antifolate (2)

Cysteine Protease (2)

Leukotriene Receptor (2)

Glutaminase (2)

CXCR (2)

PTEN (2)

GluR (2)

BCRP (2)

P-gp (2)

STING (2)

Free radical scavengers (2)

transporter (2)

PAI-1 (2)

GPX (2)

Phospholipase (2)

GABA Receptor (2)

5-HT Receptor (2)

Cannabinoid Receptor (2)

Gap Junction Protein (2)

Discoidin Domain Receptor (DDR) (2)

cholecystokinin (2)

HIF/HIF Prolyl-Hydroxylase (2)

NO Synthase (2)

S1P Receptor (2)

Mdm2 (1)

ATPase (1)

NOS (1)

Transferase (1)

ROR (1)

Dopamine Receptor (1)

NUDIX hydrolase (1)

Integrin (1)

MyD88 (1)

LPL Receptor (1)

BACE (1)

RAR/RXR (1)

MRP (1)

HBV (1)

cell cycle arrest (1)

Glucokinase (1)

Immunology/Inflammation related (1)

IAP (1)

Myosin (1)

FLAP (1)

Haspin Kinase (1)

LDL (1)

AAK1 (AP2 associated kinase 1) (1)

Antifection (1)

Opioid Receptor (1)

PROTAC Linker (1)

APC (1)

Hedgehog/Smoothened (1)

FAAH (1)

CCR (1)

Endothelin Receptor (1)

Somatostatin (1)

Epoxide Hydrolase (1)

KSP (1)

cAMP (1)

DNA (1)

Indoleamine 2,3-Dioxygenase (IDO) (1)

SGLT (1)

ATP Citrate Lyase (1)

OXPHOS (1)

Beta-Secretase (1)

MNK (1)

Acyltransferase (1)

Histone Acetyltransferase (1)

Decarboxylase (1)

cGAS (1)

HuR (1)

RSV (1)

GST (1)

Reverse Transcriptase (1)

Retinoid Receptor (1)

Ligand for E3 Ligase (1)

CRISPR/Cas9 (1)

Adenosine deaminase (1)

AChR (1)

DAPK (1)

Thrombin (1)

Protease-activated Receptor (1)

ROS Kinase (1)

AhR (1)

化合物库信息示例

Empty	1000025-07-9	1000413-72-8	229005-80-5	1000787-75-6	946387-07-1	1000998-59-3	1175526-27-8	1001288-58-9	1001350-96-4	1001404-83-6	Empty
Empty	Vadadustat	TAK875	TAK-779	Tegobuvir	RN-1734	BMS-687453	AM211	FT011	BMS754807	AAI101	Empty
Empty	1001625-82-6	1001645-58-4	1001753-24-7	1001908-89-9	1002304-34-8	1002-84-2	100291-86-9	100299-08-9	10030-52-1	10040-45-6	Empty
Empty	RPW-24	SRT1720 hydrochloride	INH6	SRT 2183	AMG208	Pentadecanoic acid	Apiopaeonoside	Pemirolast potassium	L-Anserine nitrate salt	Sodium Picosulfate	Empty
Empty	100427-26-7	1004316-88-4	10045-45-1	100462-37-1	1004990-28-6	100-51-6	1005-24-9	1005264-47-0	1005334-57-5	1005342-46-0	Empty
Empty	Lercanidipine	Cobicistat	1-Ethyl-2-benzimidazolinone	ROSIRIDIN	PF-AKT400	Benzyl alcohol	1-Methylnicotinamide chloride	MX69	CVT-10216	LCL161	Empty
Empty	1005491-05-3	100-55-0	1005504-62-0	1005883-72-6	100643-71-8	1007207-67-1	10075-50-0	1007647-73-5	100784-20-1	10083-24-6	Empty
Empty	Tirasemtiv	Roniacol	Rg3039	Z433927330	Desloratadine	CH5132799	5-Bromoindole	Smurf1-IN-A01	Halosulfuron-methyl	Piceatannol	Empty
Empty	100872-83-1	100874-08-6	1009119-64-5	1009119-65-6	100929-71-3	1009298-09-2	1009298-59-2	100929-99-5	1009734-33-1	10097-84-4	Empty
Empty	ML346	SB 4	Daclatasvir	Daclatasvir dihydrochloride	NADPH (tetracyclohexanamine)	AZD8055	Vistusertib	PAβN dihydrochloride	HZ1157	Rotundine	Empty
Empty	1009816-48-1	1009817-63-3	1009820-21-6	100986-85-4	101001-34-7	1010411-21-8	1010-60-2	1011244-68-0	1011301-27-1	1011529-10-4	Empty
Empty	Thiamet G	B-AP15	Silmitasertib	Levofloxacin	Pamicogrel	GSK369796 Dihydrochloride	2-Chloronaphthoquinone	TFAP	Tenovin3	Azvudine	Empty
Empty	101152-94-7	101155-02-6	1011557-82-6	1011-74-1	101-20-2	1012054-59-9	101-21-3	101-26-8	101303-98-4	1013101-36-4	Empty
Empty	Milnacipran hydrochloride	BW-A78U	Tenovin-6	DL-Normetanephrine hydrochloride	Triclocarban	CUDC101	Chlorpropham	Mestinon	Zacopride hydrochloride	PF04691502	Empty
Empty	101-31-5	1013-69-0	1013750-77-0	1013753-99-5	10138-52-0	1013920-15-4	1013937-63-7	1014691-61-2	101477-54-7	101494-95-5	Empty
Empty	L-Hyoscyamine	Noreugenin	ML-030	BC-1382	Gadolinium chloride	Vorolanib	VTP-27999 TFA	GSK0660	Lomerizine hydrochloride	8-CHLOROQUINAZOLIN-4(1H)-ONE	Empty

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