抗卵巢癌化合物库

Anti-Ovarian Cancer Compound Library

产品编号： L2196

卵巢癌是一种恶性肿瘤，起源于女性卵巢组织，其中，90%～95%的卵巢癌是原发性癌，即起源于卵巢本身；另外5%～10%的癌症是从其他部位扩散到卵巢的转移癌。卵巢癌的早期阶段通常没有明显症状，即使有症状也不具备特异性，因此早期诊断相对困难。大约60%～70%的患者在就诊时已经进入晚期，而晚期患者的治疗效果较差。虽然卵巢癌的发病率低于宫颈癌和子宫内膜癌，但卵巢癌的死亡率超过了宫颈癌和子宫内膜癌的总和，并且卵巢癌的死亡率呈逐年上升的趋势，严重威胁着女性的健康。如何有效的提高卵巢癌患者的生存期已成为妇科肿瘤亟待攻克的难题。近年来，分子靶向药物研发取得了突飞猛进的进展。研究发现，针对卵巢癌相关治疗靶点的药物在提升患者生存期方面发挥了显著作用。靶向药物的开发为卵巢癌患者带来了希望，为他们提供了更有效的治疗策略。 TargetMol 抗卵巢癌化合物库收集了2232 种与卵巢癌相关的化合物，包括已经报道具有治疗卵巢癌作用的化合物，以及潜在治疗卵巢癌的化合物，是抗卵巢癌药物研发的良好工具。

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产品规格

技术资料

陶术生物化合物库目录(2.8MB)

库化合物信息

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产品描述

2232种与卵巢癌相关的化合物，可以用于抗卵巢癌药物研发和药理研究；
通路靶点包含PARP、VEGF、PD-1、HER2等；
部分化合物已上市或进入临床期；
详细的说明书，化合物结构、靶点信息、IC50值、活性描述等；
NMR、HPLC/LCMS等多种检测技术保证产品结构正确，纯度高，减少假阳性。

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化合物库组成

Apoptosis (333)

NF-κB (265)

Autophagy (244)

PI3K (200)

EGFR (192)

Reactive Oxygen Species (175)

VEGFR (150)

Wnt/beta-catenin (120)

mTOR (112)

p38 MAPK (108)

Akt (104)

ERK (103)

Estrogen Receptor/ERR (92)

PARP (90)

Endogenous Metabolite (88)

GSK-3 (82)

AMPK (81)

Antibacterial (76)

Raf (74)

TGF-beta/Smad (68)

CDK (67)

MAPK (59)

PDGFR (58)

Estrogen/progestogen Receptor (56)

JNK (54)

Ras (54)

Kras (48)

IκB/IKK (47)

MEK (44)

TNF (43)

FGFR (42)

COX (41)

c-Kit (41)

Src (39)

FLT (39)

NOD (38)

DNA-PK (37)

RIP kinase (35)

HER (32)

S6 Kinase (30)

ATM/ATR (29)

Parasite (28)

Antioxidant (26)

ALK (26)

JAK (25)

IL Receptor (25)

STAT (25)

c-Met/HGFR (24)

Caspase (24)

PKC (24)

PDK (23)

IRAK (23)

Antifungal (22)

DNA/RNA Synthesis (22)

Influenza Virus (22)

Ferroptosis (21)

Antibiotic (21)

PPAR (20)

HIV Protease (19)

Calcium Channel (19)

P450 (19)

c-RET (19)

Topoisomerase (18)

NO Synthase (18)

PKA (17)

Rho (16)

Bcr-Abl (15)

Aurora Kinase (15)

Nrf2 (15)

Casein Kinase (15)

PI4K (15)

Mitophagy (14)

BCL (14)

MMP (14)

IGF-1R (14)

NOD-like Receptor (NLR) (14)

ROS (13)

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Dehydrogenase (11)

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transporter (3)

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Leukotriene Receptor (2)

PYK2 (2)

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Immunology/Inflammation related (2)

IRE1 (2)

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AAK1 (AP2 associated kinase 1) (2)

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ACK (2)

Lipid (2)

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STING (2)

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Apelin receptor (1)

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gp120/CD4 (1)

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iGluR (1)

PAFR (1)

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Smo (1)

Fatty Acid Synthase (1)

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CXCR (1)

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Indoleamine 2,3-Dioxygenase (IDO) (1)

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Discoidin Domain Receptor (DDR) (1)

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cholecystokinin (1)

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ROS Kinase (1)

CFTR (1)

PKM (1)

Monoamine Oxidase (1)

Kinesin (1)

化合物库信息示例

Empty	1000025-07-9	1000413-72-8	229005-80-5	1000787-75-6	946387-07-1	1000998-59-3	1175526-27-8	1001288-58-9	1001350-96-4	1001404-83-6	Empty
Empty	Vadadustat	TAK875	TAK-779	Tegobuvir	RN-1734	BMS-687453	AM211	FT011	BMS754807	AAI101	Empty
Empty	1001625-82-6	1001645-58-4	1001753-24-7	1001908-89-9	1002304-34-8	1002-84-2	100291-86-9	100299-08-9	10030-52-1	10040-45-6	Empty
Empty	RPW-24	SRT1720 hydrochloride	INH6	SRT 2183	AMG208	Pentadecanoic acid	Apiopaeonoside	Pemirolast potassium	L-Anserine nitrate salt	Sodium Picosulfate	Empty
Empty	100427-26-7	1004316-88-4	10045-45-1	100462-37-1	1004990-28-6	100-51-6	1005-24-9	1005264-47-0	1005334-57-5	1005342-46-0	Empty
Empty	Lercanidipine	Cobicistat	1-Ethyl-2-benzimidazolinone	ROSIRIDIN	PF-AKT400	Benzyl alcohol	1-Methylnicotinamide chloride	MX69	CVT-10216	LCL161	Empty
Empty	1005491-05-3	100-55-0	1005504-62-0	1005883-72-6	100643-71-8	1007207-67-1	10075-50-0	1007647-73-5	100784-20-1	10083-24-6	Empty
Empty	Tirasemtiv	Roniacol	Rg3039	Z433927330	Desloratadine	CH5132799	5-Bromoindole	Smurf1-IN-A01	Halosulfuron-methyl	Piceatannol	Empty
Empty	100872-83-1	100874-08-6	1009119-64-5	1009119-65-6	100929-71-3	1009298-09-2	1009298-59-2	100929-99-5	1009734-33-1	10097-84-4	Empty
Empty	ML346	SB 4	Daclatasvir	Daclatasvir dihydrochloride	NADPH (tetracyclohexanamine)	AZD8055	Vistusertib	PAβN dihydrochloride	HZ1157	Rotundine	Empty
Empty	1009816-48-1	1009817-63-3	1009820-21-6	100986-85-4	101001-34-7	1010411-21-8	1010-60-2	1011244-68-0	1011301-27-1	1011529-10-4	Empty
Empty	Thiamet G	B-AP15	Silmitasertib	Levofloxacin	Pamicogrel	GSK369796 Dihydrochloride	2-Chloronaphthoquinone	TFAP	Tenovin3	Azvudine	Empty
Empty	101152-94-7	101155-02-6	1011557-82-6	1011-74-1	101-20-2	1012054-59-9	101-21-3	101-26-8	101303-98-4	1013101-36-4	Empty
Empty	Milnacipran hydrochloride	BW-A78U	Tenovin-6	DL-Normetanephrine hydrochloride	Triclocarban	CUDC101	Chlorpropham	Mestinon	Zacopride hydrochloride	PF04691502	Empty
Empty	101-31-5	1013-69-0	1013750-77-0	1013753-99-5	10138-52-0	1013920-15-4	1013937-63-7	1014691-61-2	101477-54-7	101494-95-5	Empty
Empty	L-Hyoscyamine	Noreugenin	ML-030	BC-1382	Gadolinium chloride	Vorolanib	VTP-27999 TFA	GSK0660	Lomerizine hydrochloride	8-CHLOROQUINAZOLIN-4(1H)-ONE	Empty

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