大环化合物库AN

AN Macrocycles Library

产品编号： AN3300

长期以来，药物化学家一直将中型和大型环的化合物视为一类独特的分子，这不仅因为它们具有有趣的物理化学和生物学特性，还因为它们在合成方面具有挑战性。

ASINEX通过使用固相负载合成、RCM、点击化学和环扩展等有效的合成方法，构建了一个多样化的大环化合物库。所得到的分子结构是全新的，使我们能够生成非常多样化的与药物化学相关的大环骨架。大环化合物往往比传统的筛选分子要大，这使它们成为探索具有浅表面或延伸结合位点的靶点的完美工具。同时，它们具有独特的性质，如有限的柔性和形成分子内氢键的能力，使得设计方法能够有效地优化其水溶性和膜渗透性等性质。我们的许多大环化合物已经进行了水和DMSO溶解度的测试，DMSO溶解度的截断值为10 mM，PBS（pH 7.4）中的溶解度截断值为50 µM，随后进行了PAMPA渗透性测定。由于其受限的构象柔性以及周边取代基的有利取向，许多大环化合物能够有效地模拟与生物相关的蛋白质的α-螺旋或β-发夹拓扑结构。我们的大环化合物库提供了丰富的类肽模拟物，并且非常适合研究包括蛋白质相互作用、蛋白酶和抗菌剂等具有挑战性的靶点类别。为了解决合成可行性的问题，ASINEX利用固相负载合成、RCM、点击化学和环扩展等有效的合成方法，精心设计了一个多样化的大环化合物库。该库包含10091个化合物。

陶术生物的所有产品和服务仅用于科学研究，我们不为任何个人用途提供产品和服务。

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Product Description

ASINEX has elaborated a library of diverse macrocycles using an effective toolbox of synthetic methods including solid phase-supported synthesis, RCM, click-chemistry, and ring expansion. The resulting scaffolds are novel and have allowed us to generate tremendously diverse, Medchem relevant, macrocyclic frameworks. Macrocycles tend to be larger than traditional screening molecules which makes them perfect discovery tools for targets with shallow or extended binding sites. At the same time, their unique character based on restricted flexibility and ability to form intra-molecular hydrogen bonds allows for design approaches effectively optimizing properties such as aqueous solubility and membrane permeability. Many of our macrocycles have been tested for aqueous and DMSO solubility with cut-offs applied at 10 mM in DMSO and 50 µM in PBS (pH 7.4) followed by PAMPA permeability assay. Due to their restricted conformational flexibility accompanied by a favorable orientation of peripheral substituents, many macrocycles effectively mimic the ɑ-helical or β-hairpin topology of biologically relevant proteins. Our Macrocyclic Library provides a very rich source of peptidomimetics and is ideal for probing challenging target classes including protein-protein interactions, proteases, and antibacterials.

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化合物库信息示例

Empty	1000025-07-9	1000413-72-8	229005-80-5	1000787-75-6	946387-07-1	1000998-59-3	1175526-27-8	1001288-58-9	1001350-96-4	1001404-83-6	Empty
Empty	Vadadustat	TAK875	TAK-779	Tegobuvir	RN-1734	BMS-687453	AM211	FT011	BMS754807	AAI101	Empty
Empty	1001625-82-6	1001645-58-4	1001753-24-7	1001908-89-9	1002304-34-8	1002-84-2	100291-86-9	100299-08-9	10030-52-1	10040-45-6	Empty
Empty	RPW-24	SRT1720 hydrochloride	INH6	SRT 2183	AMG208	Pentadecanoic acid	Apiopaeonoside	Pemirolast potassium	L-Anserine nitrate salt	Sodium Picosulfate	Empty
Empty	100427-26-7	1004316-88-4	10045-45-1	100462-37-1	1004990-28-6	100-51-6	1005-24-9	1005264-47-0	1005334-57-5	1005342-46-0	Empty
Empty	Lercanidipine	Cobicistat	1-Ethyl-2-benzimidazolinone	ROSIRIDIN	PF-AKT400	Benzyl alcohol	1-Methylnicotinamide chloride	MX69	CVT-10216	LCL161	Empty
Empty	1005491-05-3	100-55-0	1005504-62-0	1005883-72-6	100643-71-8	1007207-67-1	10075-50-0	1007647-73-5	100784-20-1	10083-24-6	Empty
Empty	Tirasemtiv	Roniacol	Rg3039	Z433927330	Desloratadine	CH5132799	5-Bromoindole	Smurf1-IN-A01	Halosulfuron-methyl	Piceatannol	Empty
Empty	100872-83-1	100874-08-6	1009119-64-5	1009119-65-6	100929-71-3	1009298-09-2	1009298-59-2	100929-99-5	1009734-33-1	10097-84-4	Empty
Empty	ML346	SB 4	Daclatasvir	Daclatasvir dihydrochloride	NADPH (tetracyclohexanamine)	AZD8055	Vistusertib	PAβN dihydrochloride	HZ1157	Rotundine	Empty
Empty	1009816-48-1	1009817-63-3	1009820-21-6	100986-85-4	101001-34-7	1010411-21-8	1010-60-2	1011244-68-0	1011301-27-1	1011529-10-4	Empty
Empty	Thiamet G	B-AP15	Silmitasertib	Levofloxacin	Pamicogrel	GSK369796 Dihydrochloride	2-Chloronaphthoquinone	TFAP	Tenovin3	Azvudine	Empty
Empty	101152-94-7	101155-02-6	1011557-82-6	1011-74-1	101-20-2	1012054-59-9	101-21-3	101-26-8	101303-98-4	1013101-36-4	Empty
Empty	Milnacipran hydrochloride	BW-A78U	Tenovin-6	DL-Normetanephrine hydrochloride	Triclocarban	CUDC101	Chlorpropham	Mestinon	Zacopride hydrochloride	PF04691502	Empty
Empty	101-31-5	1013-69-0	1013750-77-0	1013753-99-5	10138-52-0	1013920-15-4	1013937-63-7	1014691-61-2	101477-54-7	101494-95-5	Empty
Empty	L-Hyoscyamine	Noreugenin	ML-030	BC-1382	Gadolinium chloride	Vorolanib	VTP-27999 TFA	GSK0660	Lomerizine hydrochloride	8-CHLOROQUINAZOLIN-4(1H)-ONE	Empty

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