表观遗传库 | TargetMol

Epigenetics Compound Library

产品编号： L1200

表观遗传学主要研究“表观遗传现象”的机制，包括：基因选择性转录的调控，有DNA 甲基化、基因印记、组蛋白共价修饰和染色质重塑；和基因转录后的调控，有基因组中非编码RNA、微小RNA、反义RNA、内含子及核糖开关等。表征遗传具有解释老化机制、人类发育和癌症起源等疾病的潜力。例如，文献报道原癌基因区的表征遗传控制和肿瘤抑制序列可通过组蛋白构象变化而直接影响癌症的形成和进展。

TargetMol 表观遗传库收集1090 种表观遗传相关的活性小分子，适用于表观遗传学研究，可用于高通量、高内涵筛选。

陶术生物的所有产品和服务仅用于科学研究，我们不为任何个人用途提供产品和服务。

产品规格

技术资料

陶术生物化合物库目录(2.8MB)

库化合物信息

Excel

SDF

产品描述

数量：精选1090种表观遗传相关活性的化合物，且含有多种结构新颖的小分子，用于表观遗传学研究及其相关的检测和高通量、高内涵筛选；
靶点含HDAC、SIRT、HAT以及HMT等十多种表观遗传相关靶点；
信息详尽：化合物结构、靶点信息、活性描述等，为活性实验开展提供参考；
NMR、LCMS/HPLC检测技术保证产品高纯度和高质量。

化合物库定制

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化合物库组成

Epigenetic Reader Domain (172)

Apoptosis (142)

Histone Methyltransferase (139)

HDAC (117)

JAK (101)

PARP (79)

PKC (71)

Autophagy (67)

Aurora Kinase (54)

Histone Demethylase (53)

Sirtuin (52)

AMPK (48)

Histone Acetyltransferase (33)

CDK (32)

Tyrosine Kinases (29)

FLT (24)

Pim (23)

DNA Methyltransferase (22)

Wnt/beta-catenin (15)

Src (14)

VEGFR (14)

PKA (13)

HIV Protease (12)

PROTACs (12)

EGFR (12)

PDGFR (10)

STAT (10)

FGFR (10)

Mitophagy (9)

ROCK (9)

Bcr-Abl (9)

Akt (9)

c-RET (9)

ERK (8)

PAD (7)

PI3K (6)

GSK-3 (6)

Parasite (6)

Serine/threonin kinase (6)

Topoisomerase (6)

Antibacterial (6)

Casein Kinase (6)

Methionine Adenosyltransferase (MAT) (6)

Influenza Virus (6)

PLK (6)

MEK (6)

Syk (6)

Virus Protease (5)

S6 Kinase (5)

Antibiotic (5)

p38 MAPK (4)

Ligands for Target Protein for PROTAC (4)

Antifungal (4)

DYRK (4)

Calcium Channel (4)

Chk (4)

CaMK (4)

DNA/RNA Synthesis (4)

Endogenous Metabolite (4)

Dehydrogenase (3)

Histamine Receptor (3)

Nucleoside Antimetabolite/Analog (3)

MAO (3)

BTK (3)

DNA Alkylation (3)

IGF-1R (3)

COX (3)

DUB (3)

mTOR (3)

PSMA (3)

MAPK (3)

Antiviral (3)

Trk receptor (3)

Carboxypeptidase (3)

c-Fms (3)

SGK (3)

Potassium Channel (3)

AChR (3)

p53 (3)

Monoamine Oxidase (3)

Dopamine Receptor (2)

YAP (2)

Adenosine Receptor (2)

IFNAR (2)

JNK (2)

Phosphatase (2)

c-Myc (2)

HBV (2)

PPAR (2)

Serine Protease (2)

Myosin (2)

PDE (2)

HSV (2)

TGF-beta/Smad (2)

SARS-CoV (2)

HuR (2)

IκB/IKK (2)

Hippo pathway (2)

5-HT Receptor (2)

GABA Receptor (2)

DAPK (2)

c-Kit (2)

cholecystokinin (2)

MLK (2)

PD-1/PD-L1 (2)

HER (2)

Proteasome (1)

Mdm2 (1)

Chloride channel (1)

Transferase (1)

DNA-PK (1)

HCV Protease (1)

Ferroptosis (1)

c-Met/HGFR (1)

RAAS (1)

Tie-2 (1)

Estrogen Receptor/ERR (1)

Antifolate (1)

Glucokinase (1)

Caspase (1)

Adrenergic Receptor (1)

SIK (1)

E1/E2/E3 Enzyme (1)

RIP kinase (1)

Gamma-secretase (1)

Raf (1)

GRK (1)

Drug Metabolite (1)

P2X Receptor (1)

DNA gyrase (1)

Mitochondrial Metabolism (1)

BCL (1)

Reactive Oxygen Species (1)

Fatty Acid Synthase (1)

Thrombopoietin Receptor (1)

Androgen Receptor (1)

Interleukin (1)

ATP Citrate Lyase (1)

AChE (1)

Acyltransferase (1)

P-gp (1)

LRRK2 (1)

MELK (1)

Reverse Transcriptase (1)

Phospholipase (1)

P450 (1)

BMI-1 (1)

Sodium Channel (1)

TAM Receptor (1)

化合物库信息示例

Empty	1000025-07-9	1000413-72-8	229005-80-5	1000787-75-6	946387-07-1	1000998-59-3	1175526-27-8	1001288-58-9	1001350-96-4	1001404-83-6	Empty
Empty	Vadadustat	TAK875	TAK-779	Tegobuvir	RN-1734	BMS-687453	AM211	FT011	BMS754807	AAI101	Empty
Empty	1001625-82-6	1001645-58-4	1001753-24-7	1001908-89-9	1002304-34-8	1002-84-2	100291-86-9	100299-08-9	10030-52-1	10040-45-6	Empty
Empty	RPW-24	SRT1720 hydrochloride	INH6	SRT 2183	AMG208	Pentadecanoic acid	Apiopaeonoside	Pemirolast potassium	L-Anserine nitrate salt	Sodium Picosulfate	Empty
Empty	100427-26-7	1004316-88-4	10045-45-1	100462-37-1	1004990-28-6	100-51-6	1005-24-9	1005264-47-0	1005334-57-5	1005342-46-0	Empty
Empty	Lercanidipine	Cobicistat	1-Ethyl-2-benzimidazolinone	ROSIRIDIN	PF-AKT400	Benzyl alcohol	1-Methylnicotinamide chloride	MX69	CVT-10216	LCL161	Empty
Empty	1005491-05-3	100-55-0	1005504-62-0	1005883-72-6	100643-71-8	1007207-67-1	10075-50-0	1007647-73-5	100784-20-1	10083-24-6	Empty
Empty	Tirasemtiv	Roniacol	Rg3039	Z433927330	Desloratadine	CH5132799	5-Bromoindole	Smurf1-IN-A01	Halosulfuron-methyl	Piceatannol	Empty
Empty	100872-83-1	100874-08-6	1009119-64-5	1009119-65-6	100929-71-3	1009298-09-2	1009298-59-2	100929-99-5	1009734-33-1	10097-84-4	Empty
Empty	ML346	SB 4	Daclatasvir	Daclatasvir dihydrochloride	NADPH (tetracyclohexanamine)	AZD8055	Vistusertib	PAβN dihydrochloride	HZ1157	Rotundine	Empty
Empty	1009816-48-1	1009817-63-3	1009820-21-6	100986-85-4	101001-34-7	1010411-21-8	1010-60-2	1011244-68-0	1011301-27-1	1011529-10-4	Empty
Empty	Thiamet G	B-AP15	Silmitasertib	Levofloxacin	Pamicogrel	GSK369796 Dihydrochloride	2-Chloronaphthoquinone	TFAP	Tenovin3	Azvudine	Empty
Empty	101152-94-7	101155-02-6	1011557-82-6	1011-74-1	101-20-2	1012054-59-9	101-21-3	101-26-8	101303-98-4	1013101-36-4	Empty
Empty	Milnacipran hydrochloride	BW-A78U	Tenovin-6	DL-Normetanephrine hydrochloride	Triclocarban	CUDC101	Chlorpropham	Mestinon	Zacopride hydrochloride	PF04691502	Empty
Empty	101-31-5	1013-69-0	1013750-77-0	1013753-99-5	10138-52-0	1013920-15-4	1013937-63-7	1014691-61-2	101477-54-7	101494-95-5	Empty
Empty	L-Hyoscyamine	Noreugenin	ML-030	BC-1382	Gadolinium chloride	Vorolanib	VTP-27999 TFA	GSK0660	Lomerizine hydrochloride	8-CHLOROQUINAZOLIN-4(1H)-ONE	Empty

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