DNA 损伤和修复分子库

DNA Damage & Repair Compound Library

产品编号： L3900

癌细胞的耐药性是癌症治疗过程中面临的主要挑战，因此鉴定新的生物学靶标，并开发设计相应的药物成为重要策略，在各种潜在候选靶标中，癌细胞 DNA Damage & Repair 系统是重要的靶标。由于抗生素的滥用，细菌等微生物的耐药性越来越强，开发靶向微生物 DNA Damage & Repair 系统的药物迫在眉睫。

TargetMol DNA 损伤和修复分子库是1040 个与DNA 损伤和修复紧密相关的化合物集合，可用于DNA 损伤和修复相关研究的高通量筛选，高内涵筛选。

陶术生物的所有产品和服务仅用于科学研究，我们不为任何个人用途提供产品和服务。

产品规格

技术资料

陶术生物化合物库目录(2.8MB)

库化合物信息

Excel

SDF

产品描述

1040个与DNA损伤和修复紧密相关的化合物集合，是高通量筛选，高内涵筛选的良好载体；
涵盖与DNA损伤和修复相关的热门靶点，如HDAC、DNA/RNA Synthesis、Topoisomerase等；
通过临床前研究和临床实验，生物活性和生物安全性得到保障；
结构多样，药效显著，可渗透细胞；
详细的说明书，化合物结构、靶点信息、IC50值、活性描述等；
NMR、HPLC/LCMS等多种检测技术保证产品结构正确，纯度高，减少假阳性。

化合物库定制

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化合物库组成

DNA/RNA Synthesis (206)

Apoptosis (130)

HDAC (114)

PPAR (96)

Topoisomerase (82)

PARP (76)

Nucleoside Antimetabolite/Analog (74)

Autophagy (70)

Sirtuin (52)

Antibacterial (51)

Antibiotic (45)

DUB (44)

DNA-PK (38)

PI3K (30)

ATM/ATR (26)

DNA Alkylator/Crosslinker (22)

DHFR (20)

DNA Alkylation (20)

DNA (19)

mTOR (19)

ADC Cytotoxin (16)

HIV Protease (14)

Dehydrogenase (14)

Wnt/beta-catenin (12)

HSV (12)

Telomerase (12)

DNA gyrase (11)

Influenza Virus (11)

Endogenous Metabolite (11)

Antifolate (10)

COX (10)

SARS-CoV (10)

Virus Protease (8)

Parasite (8)

Ferroptosis (7)

Potassium Channel (6)

p53 (6)

HCV Protease (5)

CDK (5)

Epigenetic Reader Domain (5)

Reverse Transcriptase (5)

CRISPR/Cas9 (5)

BMI-1 (5)

Antifungal (4)

Mitophagy (4)

HBV (4)

TRP/TRPV Channel (4)

Bcr-Abl (4)

MTH1 (4)

Antiviral (4)

DNA Methyltransferase (4)

PKC (3)

PDE (3)

Drug Metabolite (3)

EGFR (3)

Prostaglandin Receptor (3)

NF-κB (3)

P450 (3)

Proteasome (2)

Mdm2 (2)

Transferase (2)

p38 MAPK (2)

c-Met/HGFR (2)

Antioxidant (2)

Adenosine Receptor (2)

Phosphatase (2)

Cysteine Protease (2)

Caspase (2)

Adrenergic Receptor (2)

Gamma-secretase (2)

Mitochondrial Metabolism (2)

Antifection (2)

BCL (2)

Reactive Oxygen Species (2)

JAK (2)

Akt (2)

HSP (2)

Histone Acetyltransferase (2)

cGAS (2)

Carboxypeptidase (2)

PI4K (2)

GPR (2)

AMPK (2)

Phospholipase (2)

GABA Receptor (2)

MEK (2)

Cannabinoid Receptor (2)

FLT (2)

Microtubule Associated (2)

Tyrosinase (2)

Thrombin (2)

HIF/HIF Prolyl-Hydroxylase (2)

Carbonic Anhydrase (1)

Dopamine Receptor (1)

Histone Methyltransferase (1)

Src (1)

Estrogen/progestogen Receptor (1)

Histone Demethylase (1)

Histamine Receptor (1)

c-Myc (1)

ABC (1)

PKA (1)

Tyrosine Kinases (1)

Serine/threonin kinase (1)

Leukotriene Receptor (1)

Glucokinase (1)

VEGFR (1)

ROCK (1)

ERK (1)

MAO (1)

IAP (1)

FLAP (1)

E1/E2/E3 Enzyme (1)

P2X Receptor (1)

PDGFR (1)

PAK (1)

MMP (1)

Epoxide Hydrolase (1)

Aurora Kinase (1)

IGF-1R (1)

Androgen Receptor (1)

Interleukin (1)

TGF-beta/Smad (1)

MAPK (1)

P-gp (1)

TLR (1)

LRRK2 (1)

Trk receptor (1)

Free radical scavengers (1)

Nrf2 (1)

RSV (1)

Casein Kinase (1)

IκB/IKK (1)

STAT (1)

c-Fms (1)

KLF (1)

PLK (1)

c-RET (1)

SGK (1)

AChR (1)

Syk (1)

c-Kit (1)

TAM Receptor (1)

NOD-like Receptor (NLR) (1)

MLK (1)

HER (1)

NO Synthase (1)

化合物库信息示例

Empty	1000025-07-9	1000413-72-8	229005-80-5	1000787-75-6	946387-07-1	1000998-59-3	1175526-27-8	1001288-58-9	1001350-96-4	1001404-83-6	Empty
Empty	Vadadustat	TAK875	TAK-779	Tegobuvir	RN-1734	BMS-687453	AM211	FT011	BMS754807	AAI101	Empty
Empty	1001625-82-6	1001645-58-4	1001753-24-7	1001908-89-9	1002304-34-8	1002-84-2	100291-86-9	100299-08-9	10030-52-1	10040-45-6	Empty
Empty	RPW-24	SRT1720 hydrochloride	INH6	SRT 2183	AMG208	Pentadecanoic acid	Apiopaeonoside	Pemirolast potassium	L-Anserine nitrate salt	Sodium Picosulfate	Empty
Empty	100427-26-7	1004316-88-4	10045-45-1	100462-37-1	1004990-28-6	100-51-6	1005-24-9	1005264-47-0	1005334-57-5	1005342-46-0	Empty
Empty	Lercanidipine	Cobicistat	1-Ethyl-2-benzimidazolinone	ROSIRIDIN	PF-AKT400	Benzyl alcohol	1-Methylnicotinamide chloride	MX69	CVT-10216	LCL161	Empty
Empty	1005491-05-3	100-55-0	1005504-62-0	1005883-72-6	100643-71-8	1007207-67-1	10075-50-0	1007647-73-5	100784-20-1	10083-24-6	Empty
Empty	Tirasemtiv	Roniacol	Rg3039	Z433927330	Desloratadine	CH5132799	5-Bromoindole	Smurf1-IN-A01	Halosulfuron-methyl	Piceatannol	Empty
Empty	100872-83-1	100874-08-6	1009119-64-5	1009119-65-6	100929-71-3	1009298-09-2	1009298-59-2	100929-99-5	1009734-33-1	10097-84-4	Empty
Empty	ML346	SB 4	Daclatasvir	Daclatasvir dihydrochloride	NADPH (tetracyclohexanamine)	AZD8055	Vistusertib	PAβN dihydrochloride	HZ1157	Rotundine	Empty
Empty	1009816-48-1	1009817-63-3	1009820-21-6	100986-85-4	101001-34-7	1010411-21-8	1010-60-2	1011244-68-0	1011301-27-1	1011529-10-4	Empty
Empty	Thiamet G	B-AP15	Silmitasertib	Levofloxacin	Pamicogrel	GSK369796 Dihydrochloride	2-Chloronaphthoquinone	TFAP	Tenovin3	Azvudine	Empty
Empty	101152-94-7	101155-02-6	1011557-82-6	1011-74-1	101-20-2	1012054-59-9	101-21-3	101-26-8	101303-98-4	1013101-36-4	Empty
Empty	Milnacipran hydrochloride	BW-A78U	Tenovin-6	DL-Normetanephrine hydrochloride	Triclocarban	CUDC101	Chlorpropham	Mestinon	Zacopride hydrochloride	PF04691502	Empty
Empty	101-31-5	1013-69-0	1013750-77-0	1013753-99-5	10138-52-0	1013920-15-4	1013937-63-7	1014691-61-2	101477-54-7	101494-95-5	Empty
Empty	L-Hyoscyamine	Noreugenin	ML-030	BC-1382	Gadolinium chloride	Vorolanib	VTP-27999 TFA	GSK0660	Lomerizine hydrochloride	8-CHLOROQUINAZOLIN-4(1H)-ONE	Empty

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