抗帕金森病化合物库

Anti-Parkinson's Disease Compound Library

产品编号： L9830

帕金森病（Parkinson's disease，PD）是常见的慢性神经退行性运动障碍，影响着全球1%的70岁以上的人群。其临床表现主要包括静止性震颤、运动迟缓、肌强直和姿势步态障碍，同时患者可伴有抑郁、便秘和睡眠障碍等非运动症状。帕金森病的确切病因至今未明。遗传因素、环境因素、年龄老化、氧化应激等均可能参与PD 多巴胺能神经元的变性死亡过程。目前为止没有药物可以治疗这种疾病，而现有的治疗方法仅仅在于处理其症状，但是不能延缓其进展。

根据抗PD 药物作用靶点可以分为多巴胺替代药物、多巴胺释放剂、单胺氧化酶-B（MAO-B）抑制剂、儿茶酚-O-甲基转移酶（COMT）抑制剂、多巴胺受体激动剂和辅助治疗药物（如抗胆碱能药物、抗组胺药物和抗抑郁药等）。

TargetMol 抗帕金森病化合物库收集了857 种具有抗帕金森病活性的化合物及靶向帕金森病主要靶点的化合物，可用于相关的药物开发和药理研究。

陶术生物的所有产品和服务仅用于科学研究，我们不为任何个人用途提供产品和服务。

产品规格

技术资料

陶术生物化合物库目录(2.8MB)

库化合物信息

Excel

SDF

特点

857种帕金森病相关的化合物集合，可用于高通量和高内涵筛选；
靶点含Dopamine Receptor, COMT, MAO-B, 5-HT Receptor等；
部分化合物已经得到FDA批准上市；
结构多样，药效显著，可渗透细胞；
详细的说明书，化合物结构、靶点信息、IC50值、活性描述等；
NMR、HPLC/LCMS等多种检测技术保证产品结构正确，纯度高，减少假阳性。

化合物库定制

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化合物库咨询

化合物库组成

5-HT Receptor (262)

Dopamine Receptor (177)

AChR (135)

GABA Receptor (102)

Opioid Receptor (68)

Histamine Receptor (62)

Adrenergic Receptor (60)

Apoptosis (55)

NMDAR (53)

Autophagy (51)

iGluR (43)

Endogenous Metabolite (33)

Reactive Oxygen Species (31)

GluR (29)

Serotonin Transporter (23)

Norepinephrine (21)

LRRK2 (18)

Adenosine Receptor (17)

MAO (17)

Potassium Channel (17)

Calcium Channel (16)

Antibacterial (16)

Sodium Channel (14)

P450 (13)

Monoamine Oxidase (11)

Transferase (10)

Influenza Virus (10)

Bcr-Abl (9)

AChE (9)

Parasite (8)

Mitochondrial Metabolism (8)

NF-κB (7)

ROS (6)

HIV Protease (5)

Src (5)

Dehydrogenase (5)

Antifungal (5)

Mitophagy (5)

COX (5)

Beta Amyloid (5)

Histone Methyltransferase (4)

Caspase (4)

TRP/TRPV Channel (4)

PDE (4)

BCL (4)

Aurora Kinase (4)

CaMK (4)

FLT (4)

Sigma receptor (4)

NO Synthase (4)

NOS (3)

Ferroptosis (3)

PI3K (3)

Virus Protease (3)

PARP (3)

Gamma-secretase (3)

Drug Metabolite (3)

JAK (3)

IL Receptor (3)

P-gp (3)

Trk receptor (3)

IκB/IKK (3)

TNF (3)

Antibiotic (3)

HER (3)

Chloride channel (2)

Carbonic Anhydrase (2)

Estrogen/progestogen Receptor (2)

DYRK (2)

RAAS (2)

JNK (2)

CDK (2)

Monoamine Transporter (2)

MMP (2)

Interleukin (2)

DNA/RNA Synthesis (2)

Prostaglandin Receptor (2)

transporter (2)

HDAC (2)

Phospholipase (2)

FGFR (2)

Cannabinoid Receptor (2)

Syk (2)

Anti-infection (2)

c-Kit (2)

p53 (2)

Transaminase (1)

ROR (1)

HCV Protease (1)

Amino Acids and Derivatives (1)

p38 MAPK (1)

c-Met/HGFR (1)

Na+/Ca2+ Exchanger (1)

IFNAR (1)

Arrestin (1)

RAR/RXR (1)

NADPH (1)

Histone Demethylase (1)

Progesterone Receptor (1)

Melatonin Receptor (1)

ABC (1)

PKA (1)

MRP (1)

HBV (1)

PPAR (1)

Wnt/beta-catenin (1)

Rho (1)

VEGFR (1)

ROCK (1)

Aryl Hydrocarbon Receptor (1)

Glucocorticoid Receptor (1)

IAP (1)

Annexin A (1)

E1/E2/E3 Enzyme (1)

GRK (1)

P2X Receptor (1)

Glucosidase (1)

Hexokinase (1)

DNA Alkylation (1)

FAAH (1)

Stearoyl-CoA Desaturase (SCD) (1)

HSV (1)

CCR (1)

Epigenetic Reader Domain (1)

Lipoxygenase (1)

IGF-1R (1)

DUB (1)

mTOR (1)

Androgen Receptor (1)

TGF-beta/Smad (1)

SGLT (1)

MAPK (1)

Acyltransferase (1)

OAT (1)

HSP (1)

STING (1)

Decarboxylase (1)

Nrf2 (1)

GluCls (1)

RSV (1)

Neprilysin (1)

GST (1)

STAT (1)

Retinoid Receptor (1)

CRISPR/Cas9 (1)

GPR (1)

Hydroxylase (1)

MEK (1)

SGK (1)

NOD (1)

Ras (1)

HMG-CoA Reductase (1)

S6 Kinase (1)

Microtubule Associated (1)

Tyrosinase (1)

NOD-like Receptor (NLR) (1)

MLK (1)

Imidazoline Receptor (1)

化合物库信息示例

Empty	1000025-07-9	1000413-72-8	229005-80-5	1000787-75-6	946387-07-1	1000998-59-3	1175526-27-8	1001288-58-9	1001350-96-4	1001404-83-6	Empty
Empty	Vadadustat	TAK875	TAK-779	Tegobuvir	RN-1734	BMS-687453	AM211	FT011	BMS754807	AAI101	Empty
Empty	1001625-82-6	1001645-58-4	1001753-24-7	1001908-89-9	1002304-34-8	1002-84-2	100291-86-9	100299-08-9	10030-52-1	10040-45-6	Empty
Empty	RPW-24	SRT1720 hydrochloride	INH6	SRT 2183	AMG208	Pentadecanoic acid	Apiopaeonoside	Pemirolast potassium	L-Anserine nitrate salt	Sodium Picosulfate	Empty
Empty	100427-26-7	1004316-88-4	10045-45-1	100462-37-1	1004990-28-6	100-51-6	1005-24-9	1005264-47-0	1005334-57-5	1005342-46-0	Empty
Empty	Lercanidipine	Cobicistat	1-Ethyl-2-benzimidazolinone	ROSIRIDIN	PF-AKT400	Benzyl alcohol	1-Methylnicotinamide chloride	MX69	CVT-10216	LCL161	Empty
Empty	1005491-05-3	100-55-0	1005504-62-0	1005883-72-6	100643-71-8	1007207-67-1	10075-50-0	1007647-73-5	100784-20-1	10083-24-6	Empty
Empty	Tirasemtiv	Roniacol	Rg3039	Z433927330	Desloratadine	CH5132799	5-Bromoindole	Smurf1-IN-A01	Halosulfuron-methyl	Piceatannol	Empty
Empty	100872-83-1	100874-08-6	1009119-64-5	1009119-65-6	100929-71-3	1009298-09-2	1009298-59-2	100929-99-5	1009734-33-1	10097-84-4	Empty
Empty	ML346	SB 4	Daclatasvir	Daclatasvir dihydrochloride	NADPH (tetracyclohexanamine)	AZD8055	Vistusertib	PAβN dihydrochloride	HZ1157	Rotundine	Empty
Empty	1009816-48-1	1009817-63-3	1009820-21-6	100986-85-4	101001-34-7	1010411-21-8	1010-60-2	1011244-68-0	1011301-27-1	1011529-10-4	Empty
Empty	Thiamet G	B-AP15	Silmitasertib	Levofloxacin	Pamicogrel	GSK369796 Dihydrochloride	2-Chloronaphthoquinone	TFAP	Tenovin3	Azvudine	Empty
Empty	101152-94-7	101155-02-6	1011557-82-6	1011-74-1	101-20-2	1012054-59-9	101-21-3	101-26-8	101303-98-4	1013101-36-4	Empty
Empty	Milnacipran hydrochloride	BW-A78U	Tenovin-6	DL-Normetanephrine hydrochloride	Triclocarban	CUDC101	Chlorpropham	Mestinon	Zacopride hydrochloride	PF04691502	Empty
Empty	101-31-5	1013-69-0	1013750-77-0	1013753-99-5	10138-52-0	1013920-15-4	1013937-63-7	1014691-61-2	101477-54-7	101494-95-5	Empty
Empty	L-Hyoscyamine	Noreugenin	ML-030	BC-1382	Gadolinium chloride	Vorolanib	VTP-27999 TFA	GSK0660	Lomerizine hydrochloride	8-CHLOROQUINAZOLIN-4(1H)-ONE	Empty

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