抗阿尔茨海默症化合物库

Anti-Alzheimer's Disease Compound Library

产品编号： L9840

阿尔茨海默症（Alzheimer's disease, AD）是一种严重的神经退行性疾病，临床上以记忆障碍、失语、失用、失认、视空间技能损害、执行功能障碍以及人格和行为改变等全面性痴呆表现为特征，病因迄今未明。该病现在已经成为威胁老人健康的四大杀手之一，极大地影响了个人、家庭乃至社会的发展。当前，已发现的AD 病理途径主要包括乙酰胆碱功能障碍，增加的β淀粉样（β-amyloid, Aβ）蛋白沉积，神经纤维的缠结，以及其他的与生物靶点相关的途径。研究发现可通过抑制β-淀粉样蛋白的聚集和沉淀；防止tau 蛋白的异常过度磷酸化；改善线粒体功能障碍，抑制神经元凋亡；抑制过度增殖活化的小胶质细胞及减少白细胞介素-1和肿瘤坏死因子-α的含量；减少氧化应激损伤障碍；调节胆碱能系统相关靶点；抑制谷氨酸受体的过度激活，减少谷氨酸引起的神经元毒性等方面预防和治疗阿尔茨海默症。

在AD 发病机制尚未完全研究清楚之前，针对 AD 的治疗只能是对症治疗，这并不能从根本上治愈 AD 患者。所以，找到可逆转疾病进程的药物才是攻克AD 这一疾病的关键。众多临床试验失败的教训提示单一靶点的治疗对于AD 这种复杂疾病很难奏效。而多靶点药物和鸡尾酒组方药物可能是未来AD 药物研发的一个重要方向。此外通过小分子化合物促进神经再生也可能是一种新的研发策略。

为满足阿尔茨海默症研究人员的需求，TargetMol 抗阿尔茨海默症化合物库收集了986 种具有抗阿尔茨海默症活性的化合物及靶向阿尔兹海默症主要靶点的化合物，可用于相关的药物开发和药理研究。

陶术生物的所有产品和服务仅用于科学研究，我们不为任何个人用途提供产品和服务。

产品规格

技术资料

陶术生物化合物库目录(2.8MB)

库化合物信息

Excel

SDF

特点

986种阿尔茨海默症相关的化合物集合，可用于高通量和高内涵筛选；
靶点含tau protein, γ Secretase, 5-HT Receptor, BACE等；
部分化合物已经得到FDA批准上市；?
结构多样，药效显著，可渗透细胞；
详细的说明书，化合物结构、靶点信息、IC50值、活性描述等；
NMR、HPLC/LCMS等多种检测技术保证产品结构正确，纯度高，减少假阳性。

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化合物库组成

Adrenergic Receptor (191)

AChR (178)

5-HT Receptor (152)

Dopamine Receptor (95)

Autophagy (78)

PDE (70)

Apoptosis (64)

GABA Receptor (58)

iGluR (57)

Endogenous Metabolite (56)

NMDAR (53)

Beta Amyloid (51)

AChE (41)

Histamine Receptor (33)

GSK-3 (32)

GluR (32)

Gamma-secretase (30)

PPAR (25)

Potassium Channel (20)

Antibacterial (19)

Norepinephrine (18)

Calcium Channel (17)

Serotonin Transporter (17)

Sodium Channel (16)

HIV Protease (15)

Adenosine Receptor (14)

MAO (13)

Influenza Virus (13)

P450 (13)

Monoamine Oxidase (13)

NF-κB (12)

CDK (11)

COX (11)

BACE (10)

Ferroptosis (10)

Cannabinoid Receptor (10)

Parasite (9)

Beta-Secretase (9)

TNF (9)

Mitophagy (8)

Reactive Oxygen Species (8)

Nrf2 (8)

JNK (6)

Antifungal (6)

CaMK (6)

Antibiotic (6)

Microtubule Associated (6)

Antioxidant (5)

Virus Protease (5)

Caspase (5)

ERK (5)

IL Receptor (5)

P-gp (5)

HDAC (5)

Anti-infection (5)

Src (4)

Estrogen/progestogen Receptor (4)

Transferase (4)

Dehydrogenase (4)

PKA (4)

Wnt/beta-catenin (4)

Drug Metabolite (4)

Opioid Receptor (4)

Epigenetic Reader Domain (4)

Akt (4)

HMG-CoA Reductase (4)

NO Synthase (4)

Phospholipase (4)

c-Kit (4)

Tyrosinase (4)

Phosphatase (3)

Amino Acids and Derivatives (3)

PI3K (3)

Estrogen Receptor/ERR (3)

PARP (3)

VEGFR (3)

TRP/TRPV Channel (3)

Glucocorticoid Receptor (3)

Mitochondrial Metabolism (3)

PKC (3)

BCL (3)

HSV (3)

MMP (3)

Lipoxygenase (3)

EGFR (3)

Sirtuin (3)

CCR (3)

Trk receptor (3)

IκB/IKK (3)

c-Fms (3)

AMPK (3)

MEK (3)

FLT (3)

Sigma receptor (3)

HIF/HIF Prolyl-Hydroxylase (3)

Imidazoline Receptor (3)

Chloride channel (2)

Carbonic Anhydrase (2)

Histone Methyltransferase (2)

RAAS (2)

advanced glycation end products (2)

p38 MAPK (2)

Raf (2)

MRP (2)

CSF-1R (2)

Immunology/Inflammation related (2)

Monoamine Transporter (2)

Guanylate cyclase (2)

Aurora Kinase (2)

Interleukin (2)

TGF-beta/Smad (2)

Acyltransferase (2)

transporter (2)

IGF-1R (2)

mTOR (2)

Antiviral (2)

Prostaglandin Receptor (2)

Histone Acetyltransferase (2)

FGFR (2)

Casein Kinase (2)

Reverse Transcriptase (2)

Retinoid Receptor (2)

STAT (2)

NOD (2)

S6 Kinase (2)

HER (2)

Adenylyl cyclase (1)

NOS (1)

Transaminase (1)

Monocarboxylate transporter (1)

ROR (1)

HCV Protease (1)

DYRK (1)

NADPH (1)

Progesterone Receptor (1)

Melatonin Receptor (1)

ABC (1)

Integrin (1)

Na+/Ca2+ Exchanger (1)

Histone Demethylase (1)

Serine/threonin kinase (1)

RANKL/RANK (1)

IAP (1)

Topoisomerase (1)

Annexin A (1)

Adiponectin receptor (1)

UGT (1)

Bcr-Abl (1)

LDL (1)

Rho (1)

Hck (1)

Cysteine Protease (1)

Liver X Receptor (1)

Nucleoside Antimetabolite/Analog (1)

FXR (1)

PAFR (1)

GRK (1)

MT Receptor (1)

GlyT (1)

BTK (1)

Glucosidase (1)

Stearoyl-CoA Desaturase (SCD) (1)

Chk (1)

Somatostatin (1)

DNA/RNA Synthesis (1)

SARS-CoV (1)

TLR (1)

Bombesin Receptor (1)

PDGFR (1)

PAD (1)

Epoxide Hydrolase (1)

Telomerase (1)

MAPK (1)

OAT (1)

GluCls (1)

ATM/ATR (1)

GST (1)

RSV (1)

Aromatase (1)

GPR (1)

CRISPR/Cas9 (1)

HIF (1)

Gap Junction Protein (1)

Ras (1)

FAK (1)

NOD-like Receptor (NLR) (1)

p53 (1)

化合物库信息示例

Empty	1000025-07-9	1000413-72-8	229005-80-5	1000787-75-6	946387-07-1	1000998-59-3	1175526-27-8	1001288-58-9	1001350-96-4	1001404-83-6	Empty
Empty	Vadadustat	TAK875	TAK-779	Tegobuvir	RN-1734	BMS-687453	AM211	FT011	BMS754807	AAI101	Empty
Empty	1001625-82-6	1001645-58-4	1001753-24-7	1001908-89-9	1002304-34-8	1002-84-2	100291-86-9	100299-08-9	10030-52-1	10040-45-6	Empty
Empty	RPW-24	SRT1720 hydrochloride	INH6	SRT 2183	AMG208	Pentadecanoic acid	Apiopaeonoside	Pemirolast potassium	L-Anserine nitrate salt	Sodium Picosulfate	Empty
Empty	100427-26-7	1004316-88-4	10045-45-1	100462-37-1	1004990-28-6	100-51-6	1005-24-9	1005264-47-0	1005334-57-5	1005342-46-0	Empty
Empty	Lercanidipine	Cobicistat	1-Ethyl-2-benzimidazolinone	ROSIRIDIN	PF-AKT400	Benzyl alcohol	1-Methylnicotinamide chloride	MX69	CVT-10216	LCL161	Empty
Empty	1005491-05-3	100-55-0	1005504-62-0	1005883-72-6	100643-71-8	1007207-67-1	10075-50-0	1007647-73-5	100784-20-1	10083-24-6	Empty
Empty	Tirasemtiv	Roniacol	Rg3039	Z433927330	Desloratadine	CH5132799	5-Bromoindole	Smurf1-IN-A01	Halosulfuron-methyl	Piceatannol	Empty
Empty	100872-83-1	100874-08-6	1009119-64-5	1009119-65-6	100929-71-3	1009298-09-2	1009298-59-2	100929-99-5	1009734-33-1	10097-84-4	Empty
Empty	ML346	SB 4	Daclatasvir	Daclatasvir dihydrochloride	NADPH (tetracyclohexanamine)	AZD8055	Vistusertib	PAβN dihydrochloride	HZ1157	Rotundine	Empty
Empty	1009816-48-1	1009817-63-3	1009820-21-6	100986-85-4	101001-34-7	1010411-21-8	1010-60-2	1011244-68-0	1011301-27-1	1011529-10-4	Empty
Empty	Thiamet G	B-AP15	Silmitasertib	Levofloxacin	Pamicogrel	GSK369796 Dihydrochloride	2-Chloronaphthoquinone	TFAP	Tenovin3	Azvudine	Empty
Empty	101152-94-7	101155-02-6	1011557-82-6	1011-74-1	101-20-2	1012054-59-9	101-21-3	101-26-8	101303-98-4	1013101-36-4	Empty
Empty	Milnacipran hydrochloride	BW-A78U	Tenovin-6	DL-Normetanephrine hydrochloride	Triclocarban	CUDC101	Chlorpropham	Mestinon	Zacopride hydrochloride	PF04691502	Empty
Empty	101-31-5	1013-69-0	1013750-77-0	1013753-99-5	10138-52-0	1013920-15-4	1013937-63-7	1014691-61-2	101477-54-7	101494-95-5	Empty
Empty	L-Hyoscyamine	Noreugenin	ML-030	BC-1382	Gadolinium chloride	Vorolanib	VTP-27999 TFA	GSK0660	Lomerizine hydrochloride	8-CHLOROQUINAZOLIN-4(1H)-ONE	Empty

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