细胞焦亡化合物库

Pyroptosis Compound Library

产品编号： L8720

细胞焦亡，又称细胞炎性坏死，是一种程序性坏死；表现为细胞不断胀大直至细胞膜破裂，导致细胞内容物的释放进而激活强烈的炎症反应。按激活机制，可分为 Caspase-1依赖的经典途径和 Caspase-1不依赖（caspase-4/5/11）的非经典途径，caspase-1和 caspase-4/5/11通过切割 Gasdermin-D（GSDMD）蛋白，释放其 N 端结构域，该结构域结合膜脂并在细胞膜上打孔，导致细胞渗透压变化而发生胀大直至细胞膜破裂。两种途径都能同时诱导IL-1β和IL-18的前体进行切割，形成成熟的IL-1β和IL-18，并释放到胞外，造成炎症反应。细胞焦亡在感染性疾病、代谢疾病、神经系统疾病、心血管疾病、癌症等疾病中有广泛的研究，对细胞焦亡的研究有助于认识其在相关疾病的发生发展。

TargetMol 细胞焦亡化合物库收集了1077 种细胞焦亡相关的化合物，可以用于细胞焦亡相关研究。

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产品规格

技术资料

陶术生物化合物库目录(28.1MB)

库化合物信息

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产品描述

1077种与细胞焦亡相关的活性小分子，可用于高通量和高内涵筛选；
靶点包括Caspase-1、Caspase-4、Caspase-5、Caspase-11、NLRP3、gasdermin D等；
部分化合物已被FDA批准上市；
详细的说明书，化合物结构、靶点信息、活性描述等；

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化合物库组成

NF-κB (219)

Apoptosis (206)

Autophagy (176)

Reactive Oxygen Species (165)

COX (136)

mTOR (86)

p38 MAPK (83)

TNF (78)

Endogenous Metabolite (77)

Caspase (75)

IL Receptor (71)

Antibacterial (59)

TLR (56)

PI3K (53)

ROS (53)

AMPK (48)

JNK (46)

IκB/IKK (38)

Akt (37)

p53 (37)

ERK (34)

Ferroptosis (24)

HIV Protease (24)

Interleukin (24)

NOD (22)

Antifungal (21)

E1/E2/E3 Enzyme (21)

NO Synthase (21)

PPAR (21)

RIP kinase (21)

Antioxidant (20)

STAT (20)

Mdm2 (19)

Parasite (19)

BCL (18)

Influenza Virus (17)

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P450 (16)

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Mitochondrial Metabolism (14)

Calcium Channel (13)

Mitophagy (13)

MMP (12)

DNA/RNA Synthesis (11)

Lipoxygenase (11)

CDK (10)

MAPK (10)

Nrf2 (10)

ROS Kinase (10)

SARS-CoV (10)

EGFR (9)

Beta Amyloid (8)

Dehydrogenase (8)

JAK (8)

PKC (8)

Potassium Channel (8)

Virus Protease (8)

ASK (7)

ATM/ATR (7)

HIF/HIF Prolyl-Hydroxylase (7)

S6 Kinase (7)

Src (7)

Topoisomerase (7)

Tyrosinase (7)

VEGFR (7)

5-HT Receptor (6)

AChE (6)

AChR (6)

ALK (6)

Estrogen/progestogen Receptor (6)

GABA Receptor (6)

IAP (6)

PGE Synthase (6)

P-gp (6)

Prostaglandin Receptor (6)

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Anti-infection (5)

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transporter (4)

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gp120/CD4 (1)

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SIK (1)

Somatostatin (1)

STING (1)

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UGT (1)

化合物库信息示例

Empty	1000025-07-9	1000413-72-8	229005-80-5	1000787-75-6	946387-07-1	1000998-59-3	1175526-27-8	1001288-58-9	1001350-96-4	1001404-83-6	Empty
Empty	Vadadustat	TAK875	TAK-779	Tegobuvir	RN-1734	BMS-687453	AM211	FT011	BMS754807	AAI101	Empty
Empty	1001625-82-6	1001645-58-4	1001753-24-7	1001908-89-9	1002304-34-8	1002-84-2	100291-86-9	100299-08-9	10030-52-1	10040-45-6	Empty
Empty	RPW-24	SRT1720 hydrochloride	INH6	SRT 2183	AMG208	Pentadecanoic acid	Apiopaeonoside	Pemirolast potassium	L-Anserine nitrate salt	Sodium Picosulfate	Empty
Empty	100427-26-7	1004316-88-4	10045-45-1	100462-37-1	1004990-28-6	100-51-6	1005-24-9	1005264-47-0	1005334-57-5	1005342-46-0	Empty
Empty	Lercanidipine	Cobicistat	1-Ethyl-2-benzimidazolinone	ROSIRIDIN	PF-AKT400	Benzyl alcohol	1-Methylnicotinamide chloride	MX69	CVT-10216	LCL161	Empty
Empty	1005491-05-3	100-55-0	1005504-62-0	1005883-72-6	100643-71-8	1007207-67-1	10075-50-0	1007647-73-5	100784-20-1	10083-24-6	Empty
Empty	Tirasemtiv	Roniacol	Rg3039	Z433927330	Desloratadine	CH5132799	5-Bromoindole	Smurf1-IN-A01	Halosulfuron-methyl	Piceatannol	Empty
Empty	100872-83-1	100874-08-6	1009119-64-5	1009119-65-6	100929-71-3	1009298-09-2	1009298-59-2	100929-99-5	1009734-33-1	10097-84-4	Empty
Empty	ML346	SB 4	Daclatasvir	Daclatasvir dihydrochloride	NADPH (tetracyclohexanamine)	AZD8055	Vistusertib	PAβN dihydrochloride	HZ1157	Rotundine	Empty
Empty	1009816-48-1	1009817-63-3	1009820-21-6	100986-85-4	101001-34-7	1010411-21-8	1010-60-2	1011244-68-0	1011301-27-1	1011529-10-4	Empty
Empty	Thiamet G	B-AP15	Silmitasertib	Levofloxacin	Pamicogrel	GSK369796 Dihydrochloride	2-Chloronaphthoquinone	TFAP	Tenovin3	Azvudine	Empty
Empty	101152-94-7	101155-02-6	1011557-82-6	1011-74-1	101-20-2	1012054-59-9	101-21-3	101-26-8	101303-98-4	1013101-36-4	Empty
Empty	Milnacipran hydrochloride	BW-A78U	Tenovin-6	DL-Normetanephrine hydrochloride	Triclocarban	CUDC101	Chlorpropham	Mestinon	Zacopride hydrochloride	PF04691502	Empty
Empty	101-31-5	1013-69-0	1013750-77-0	1013753-99-5	10138-52-0	1013920-15-4	1013937-63-7	1014691-61-2	101477-54-7	101494-95-5	Empty
Empty	L-Hyoscyamine	Noreugenin	ML-030	BC-1382	Gadolinium chloride	Vorolanib	VTP-27999 TFA	GSK0660	Lomerizine hydrochloride	8-CHLOROQUINAZOLIN-4(1H)-ONE	Empty

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