神经退行性疾病化合物库

Anti-Neurodegenerative Disease Compound Library

产品编号： L2620

神经退行性疾病是机体神经元结构或功能逐渐丧失而引发的一类疾病，包括肌萎缩侧索硬化症(Amyotrophiclateral sclerosis，ALS)、帕金森病（Parkinson’s disease，PD）、阿尔茨海默病(Alzheimer disease，AD)、亨廷顿氏病(Huntington’s disease，HD)以及脊髓性肌萎缩症(spinal muscular atrophy，SMA)等，目前这类疾病病因尚不明确并无有效治愈手段，且严重威胁着患者的生活质量。

TargetMol 基于目前的研究现状，收集了2154 种与神经退行性疾病相关的化合物，这些化合物或者对神经退行性疾病有一定的疗效，或者作用于神经退行性疾病相关的靶点，可以用于神经退行性疾病相关的药物研发和机制研究。

陶术生物的所有产品和服务仅用于科学研究，我们不为任何个人用途提供产品和服务。

产品规格

技术资料

陶术生物化合物库目录(28.1MB)

库化合物信息

Excel

SDF

产品描述

2154种与神经退行性疾病相关的化合物，可用于高通量和高内涵筛选；
靶点包括AchE, NMDA, CGRP, β-secretase, γ-secretase, Dopamine Receptor, Adenosine Receptor, 5-HT receptor等；
部分化合物已经得到FDA批准上市；
详细的说明书，化合物结构、靶点信息、活性描述等；
NMR、HPLC/LCMS等多种检测技术保证产品结构正确，纯度高，减少假阳性。

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化合物库组成

5-HT Receptor (292)

AChR (280)

Dopamine Receptor (234)

Adrenergic Receptor (206)

GABA Receptor (142)

Apoptosis (138)

GluR (127)

Autophagy (127)

Opioid Receptor (95)

AChE (95)

Histamine Receptor (93)

Endogenous Metabolite (89)

NMDAR (83)

PDE (74)

iGluR (70)

Beta Amyloid (66)

COX (64)

MAO (57)

Gamma-secretase (44)

Monoamine Oxidase (44)

JNK (41)

Serotonin Transporter (39)

Antibacterial (38)

Reactive Oxygen Species (37)

NF-κB (36)

PPAR (35)

Norepinephrine (34)

Adenosine Receptor (33)

GSK-3 (33)

Potassium Channel (33)

Caspase (28)

Sodium Channel (28)

Calcium Channel (26)

P450 (26)

Parasite (23)

Influenza Virus (20)

HIV Protease (19)

CaMK (18)

Nrf2 (18)

TNF (18)

LRRK2 (17)

BACE (16)

Mitophagy (15)

ERK (14)

CDK (14)

Ferroptosis (13)

Antifungal (13)

Mitochondrial Metabolism (12)

Beta-Secretase (12)

Dehydrogenase (11)

TRP/TRPV Channel (11)

IL Receptor (11)

Cannabinoid Receptor (11)

Antibiotic (11)

Transferase (10)

Bcr-Abl (10)

Akt (10)

Src (9)

p38 MAPK (9)

Phosphatase (9)

P-gp (9)

NO Synthase (9)

Estrogen/progestogen Receptor (8)

PI3K (8)

Virus Protease (8)

GlyT (8)

ROS (8)

MMP (8)

DNA/RNA Synthesis (8)

Phospholipase (8)

Imidazoline Receptor (8)

Antioxidant (7)

PARP (7)

BCL (7)

OX Receptor (7)

Interleukin (7)

IκB/IKK (7)

FLT (7)

Sigma receptor (7)

Microtubule Associated (7)

Adenylyl cyclase (6)

MRP (6)

Wnt/beta-catenin (6)

VEGFR (6)

PKC (6)

Drug Metabolite (6)

MT Receptor (6)

P2X Receptor (6)

Aurora Kinase (6)

Lipoxygenase (6)

Sirtuin (6)

HDAC (6)

AMPK (6)

MEK (6)

c-Kit (6)

Chloride channel (5)

LPL Receptor (5)

P2Y Receptor (5)

Melatonin Receptor (5)

PKA (5)

AAK1 (AP2 associated kinase 1) (5)

FAAH (5)

EGFR (5)

SARS-CoV (5)

S1P Receptor (5)

NOS (4)

Carbonic Anhydrase (4)

ROR (4)

Histone Methyltransferase (4)

RAAS (4)

ABC (4)

JAK (4)

HSV (4)

CCR (4)

Epigenetic Reader Domain (4)

IGF-1R (4)

mTOR (4)

Prostaglandin Receptor (4)

Trk receptor (4)

Retinoid Receptor (4)

FGFR (4)

Neurokinin receptor (4)

Anti-infection (4)

HMG-CoA Reductase (4)

Tyrosinase (4)

Amino Acids and Derivatives (3)

NADPH (3)

Histone Demethylase (3)

Estrogen Receptor/ERR (3)

Rho (3)

Glucocorticoid Receptor (3)

Glucosidase (3)

Epoxide Hydrolase (3)

TGF-beta/Smad (3)

MAPK (3)

Histone Acetyltransferase (3)

Casein Kinase (3)

c-Fms (3)

NOD (3)

S6 Kinase (3)

HIF/HIF Prolyl-Hydroxylase (3)

p53 (3)

HER (3)

advanced glycation end products (2)

Transaminase (2)

Integrin (2)

c-Met/HGFR (2)

IFNAR (2)

DYRK (2)

Progesterone Receptor (2)

HBV (2)

Cysteine Protease (2)

FXR (2)

Aryl Hydrocarbon Receptor (2)

CSF-1R (2)

Immunology/Inflammation related (2)

Topoisomerase (2)

UGT (2)

PAFR (2)

Raf (2)

BTK (2)

Antifection (2)

Monoamine Transporter (2)

Guanylate cyclase (2)

Stearoyl-CoA Desaturase (SCD) (2)

PGE Synthase (2)

Antiviral (2)

STING (2)

Free radical scavengers (2)

transporter (2)

Decarboxylase (2)

RSV (2)

ATM/ATR (2)

Reverse Transcriptase (2)

STAT (2)

GPR (2)

CRISPR/Cas9 (2)

CGRP Receptor (2)

Gap Junction Protein (2)

Ras (2)

FAK (2)

NOD-like Receptor (NLR) (2)

Proteasome (1)

ATPase (1)

NPC1L1 (1)

Monocarboxylate transporter (1)

HCV Protease (1)

Na+/Ca2+ Exchanger (1)

Arrestin (1)

RAR/RXR (1)

Glutathione Peroxidase (1)

GTPase (1)

OCT (1)

Hck (1)

Serine/threonin kinase (1)

Liver X Receptor (1)

Nucleoside Antimetabolite/Analog (1)

RANKL/RANK (1)

ROCK (1)

IAP (1)

Annexin A (1)

E1/E2/E3 Enzyme (1)

Adiponectin receptor (1)

LDL (1)

GRK (1)

Hexokinase (1)

Neuropeptide Y Receptor (1)

PAK (1)

DNA Alkylation (1)

Bombesin Receptor (1)

PDGFR (1)

Somatostatin (1)

Chk (1)

PAD (1)

DUB (1)

Indoleamine 2,3-Dioxygenase (IDO) (1)

Androgen Receptor (1)

Telomerase (1)

SGLT (1)

Acyltransferase (1)

OAT (1)

HSP (1)

TLR (1)

GluCls (1)

PAI-1 (1)

ALK (1)

Neprilysin (1)

GST (1)

Aromatase (1)

PDK (1)

Hydroxylase (1)

Adenosine deaminase (1)

HIF (1)

SGK (1)

NMU2R (1)

Syk (1)

DNA Methyltransferase (1)

IRAK (1)

Thrombin (1)

MLK (1)

化合物库信息示例

Empty	1000025-07-9	1000413-72-8	229005-80-5	1000787-75-6	946387-07-1	1000998-59-3	1175526-27-8	1001288-58-9	1001350-96-4	1001404-83-6	Empty
Empty	Vadadustat	TAK875	TAK-779	Tegobuvir	RN-1734	BMS-687453	AM211	FT011	BMS754807	AAI101	Empty
Empty	1001625-82-6	1001645-58-4	1001753-24-7	1001908-89-9	1002304-34-8	1002-84-2	100291-86-9	100299-08-9	10030-52-1	10040-45-6	Empty
Empty	RPW-24	SRT1720 hydrochloride	INH6	SRT 2183	AMG208	Pentadecanoic acid	Apiopaeonoside	Pemirolast potassium	L-Anserine nitrate salt	Sodium Picosulfate	Empty
Empty	100427-26-7	1004316-88-4	10045-45-1	100462-37-1	1004990-28-6	100-51-6	1005-24-9	1005264-47-0	1005334-57-5	1005342-46-0	Empty
Empty	Lercanidipine	Cobicistat	1-Ethyl-2-benzimidazolinone	ROSIRIDIN	PF-AKT400	Benzyl alcohol	1-Methylnicotinamide chloride	MX69	CVT-10216	LCL161	Empty
Empty	1005491-05-3	100-55-0	1005504-62-0	1005883-72-6	100643-71-8	1007207-67-1	10075-50-0	1007647-73-5	100784-20-1	10083-24-6	Empty
Empty	Tirasemtiv	Roniacol	Rg3039	Z433927330	Desloratadine	CH5132799	5-Bromoindole	Smurf1-IN-A01	Halosulfuron-methyl	Piceatannol	Empty
Empty	100872-83-1	100874-08-6	1009119-64-5	1009119-65-6	100929-71-3	1009298-09-2	1009298-59-2	100929-99-5	1009734-33-1	10097-84-4	Empty
Empty	ML346	SB 4	Daclatasvir	Daclatasvir dihydrochloride	NADPH (tetracyclohexanamine)	AZD8055	Vistusertib	PAβN dihydrochloride	HZ1157	Rotundine	Empty
Empty	1009816-48-1	1009817-63-3	1009820-21-6	100986-85-4	101001-34-7	1010411-21-8	1010-60-2	1011244-68-0	1011301-27-1	1011529-10-4	Empty
Empty	Thiamet G	B-AP15	Silmitasertib	Levofloxacin	Pamicogrel	GSK369796 Dihydrochloride	2-Chloronaphthoquinone	TFAP	Tenovin3	Azvudine	Empty
Empty	101152-94-7	101155-02-6	1011557-82-6	1011-74-1	101-20-2	1012054-59-9	101-21-3	101-26-8	101303-98-4	1013101-36-4	Empty
Empty	Milnacipran hydrochloride	BW-A78U	Tenovin-6	DL-Normetanephrine hydrochloride	Triclocarban	CUDC101	Chlorpropham	Mestinon	Zacopride hydrochloride	PF04691502	Empty
Empty	101-31-5	1013-69-0	1013750-77-0	1013753-99-5	10138-52-0	1013920-15-4	1013937-63-7	1014691-61-2	101477-54-7	101494-95-5	Empty
Empty	L-Hyoscyamine	Noreugenin	ML-030	BC-1382	Gadolinium chloride	Vorolanib	VTP-27999 TFA	GSK0660	Lomerizine hydrochloride	8-CHLOROQUINAZOLIN-4(1H)-ONE	Empty

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