抗肺癌化合物库 | 陶术生物

抗肺癌化合物库

Anti-Lung Cancer Compound Library

产品编号： L2190

根据《2018年全球癌症统计数据》报告，仅2018年，全球新增癌症病例1810万，死亡960万，其中亚洲占近70%，肺癌的发病率及死亡率居高不下（11.6%及18.4%）。肺癌的发病率和死亡率增长很快，对人群健康和生命威胁很大的恶性肿瘤之一。由于缺乏有效的治疗手段，目前肺癌的治疗目标是延长生存期，尽可能长时间地实现和维持良好的生活质量。肺癌的治疗手段包括手术、放疗、化疗、免疫治疗或联合疗法。近年来，靶向治疗和肿瘤免疫疗法成为肺癌治疗的重要发展方向，并且取得了较好的治疗效果。但是靶向药物治疗易出现耐药性的问题，随着靶向药物的不断发展、全基因组测序的不断推进，开发新一代克服耐药的靶向治疗药物是肺癌药物开发的重中之重。 TargetMol 抗肺癌化合物库收集了1735 种与肺癌相关的化合物，包括已经报道有肺癌治疗作用的化合物，以及靶向肺癌相关靶点的化合物，是抗肺癌药物研发的良好工具。此外，我们还提供已知活性库、上市药物库、天然产物库以及一系列抗癌相关化合物库，可以用于抗癌药物的研发，如果您感兴趣，欢迎与我们联系~

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产品规格

技术资料

陶术生物化合物库目录(28.1MB)

库化合物信息

Excel

SDF

产品描述

1735种与肺癌相关的化合物，可以用于抗肺癌药物研发和药理研究；
靶点包含EGFR, PI3K, FGFR, HER2, ALK, c-Met等；
部分化合物已上市或进入临床期；
详细的说明书，化合物结构、靶点信息、IC50值、活性描述等；
NMR、HPLC/LCMS等多种检测技术保证产品结构正确，纯度高，减少假阳性。

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化合物库组成

Apoptosis (346)

Autophagy (265)

NF-κB (208)

PI3K (171)

EGFR (158)

VEGFR (134)

PDGFR (93)

JAK (92)

Akt (89)

mTOR (88)

STAT (87)

FLT (84)

FGFR (79)

AMPK (69)

c-Met/HGFR (61)

c-Kit (61)

Antibacterial (57)

GSK-3 (56)

Endogenous Metabolite (53)

CDK (52)

ALK (48)

Src (47)

Wnt/beta-catenin (44)

HER (40)

DNA/RNA Synthesis (39)

DNA-PK (37)

ERK (37)

p53 (36)

COX (35)

IGF-1R (32)

TGF-beta/Smad (30)

S6 Kinase (30)

Parasite (29)

Antibiotic (29)

Mitophagy (28)

Tyrosine Kinases (28)

Bcr-Abl (28)

TNF (28)

p38 MAPK (27)

HIV Protease (26)

Reactive Oxygen Species (26)

DNA Alkylator/Crosslinker (25)

Aurora Kinase (25)

c-RET (25)

Raf (24)

TAM Receptor (24)

ATM/ATR (23)

HDAC (23)

Ferroptosis (22)

E1/E2/E3 Enzyme (22)

IL Receptor (21)

Mdm2 (20)

Pim (20)

MEK (20)

JNK (19)

PDK (19)

Topoisomerase (18)

Potassium Channel (18)

Microtubule Associated (18)

Dehydrogenase (17)

Influenza Virus (17)

PKC (16)

DNA Alkylation (16)

P450 (16)

PPAR (15)

Caspase (15)

BCL (15)

Trk receptor (15)

FAK (14)

Calcium Channel (13)

PI4K (13)

Lipoxygenase (12)

HSP (12)

c-Fms (12)

Antifungal (11)

PKA (11)

PARP (11)

ROS (11)

MMP (11)

MAPK (11)

IκB/IKK (11)

Chk (10)

Interleukin (10)

Casein Kinase (10)

Nucleoside Antimetabolite/Analog (9)

BTK (9)

Nrf2 (9)

5-HT Receptor (9)

Ras (9)

ROS Kinase (9)

Histamine Receptor (8)

Phosphatase (8)

ROCK (8)

Adrenergic Receptor (8)

PDE (8)

SARS-CoV (8)

Beta Amyloid (8)

PLK (8)

Syk (8)

Tyrosinase (8)

NO Synthase (8)

Estrogen/progestogen Receptor (7)

Adenosine Receptor (7)

Virus Protease (7)

CSF-1R (7)

PTEN (7)

Epigenetic Reader Domain (7)

TLR (7)

Sirtuin (7)

Sodium Channel (7)

NOS (6)

HCV Protease (6)

IAP (6)

SIK (6)

Drug Metabolite (6)

Mitochondrial Metabolism (6)

HSV (6)

DNA (6)

P-gp (6)

GABA Receptor (6)

AChR (6)

HIF/HIF Prolyl-Hydroxylase (6)

Proteasome (5)

DHFR (5)

Histone Methyltransferase (5)

Integrin (5)

RAAS (5)

Estrogen Receptor/ERR (5)

Glucocorticoid Receptor (5)

CaMK (5)

Prostaglandin Receptor (5)

transporter (5)

MELK (5)

Retinoid Receptor (5)

Dopamine Receptor (4)

Antioxidant (4)

Tie-2 (4)

MRP (4)

Antifolate (4)

Gamma-secretase (4)

Hedgehog/Smoothened (4)

CCR (4)

AChE (4)

Porcupine (4)

Ephrin Receptor (4)

HIF (4)

SGK (4)

NOD-like Receptor (NLR) (4)

Chloride channel (3)

ATPase (3)

Transferase (3)

IFNAR (3)

DYRK (3)

Histone Demethylase (3)

Glutathione Peroxidase (3)

Rho (3)

Serine Protease (3)

Aryl Hydrocarbon Receptor (3)

LDL (3)

Glucosidase (3)

Opioid Receptor (3)

PGE Synthase (3)

Antiviral (3)

Histone Acetyltransferase (3)

Ligand for E3 Ligase (3)

Aromatase (3)

ribosome (3)

Discoidin Domain Receptor (DDR) (3)

Anti-infection (3)

NOD (3)

HMG-CoA Reductase (3)

S1P Receptor (3)

Carbonic Anhydrase (2)

Ligands for Target Protein for PROTAC (2)

BACE (2)

Reductase (2)

Progesterone Receptor (2)

HBV (2)

Serotonin Transporter (2)

Leukotriene Receptor (2)

Glucokinase (2)

IRE1 (2)

NMDAR (2)

Antifection (2)

Molecular Glues (2)

Smo (2)

CXCR (2)

ACK (2)

Androgen Receptor (2)

Indoleamine 2,3-Dioxygenase (IDO) (2)

OXPHOS (2)

STING (2)

Reverse Transcriptase (2)

Phospholipase (2)

GHSR (2)

Cannabinoid Receptor (2)

DNA Methyltransferase (2)

cholecystokinin (2)

MLK (2)

PD-1/PD-L1 (2)

Kinesin (2)

Monoamine Oxidase (2)

Melanin-concentrating Hormone Receptor (MCHR) (1)

PROTACs (1)

NPC1L1 (1)

ROR (1)

NEDD8 (1)

CRM1 (1)

Amino Acids and Derivatives (1)

YAP (1)

LTR (1)

Na+/Ca2+ Exchanger (1)

NADPH (1)

PERK (1)

GTPase (1)

VDA (1)

Melatonin Receptor (1)

OCT (1)

c-Myc (1)

ABC (1)

Hck (1)

cell cycle arrest (1)

Serine/threonin kinase (1)

Liver X Receptor (1)

FXR (1)

PYK2 (1)

Glutaminase (1)

IDO (1)

iGluR (1)

Myosin (1)

RIP kinase (1)

UGT (1)

MTH1 (1)

Hexokinase (1)

Monoamine Transporter (1)

Guanylate cyclase (1)

PROTAC Linker (1)

Fatty Acid Synthase (1)

Bombesin Receptor (1)

Thioredoxin (1)

PAK (1)

FAAH (1)

Xanthine Oxidase (1)

KSP (1)

GluR (1)

cAMP (1)

DUB (1)

ATP Citrate Lyase (1)

Wee1 (1)

BCRP (1)

Beta-Secretase (1)

MNK (1)

Survivin (1)

LRRK2 (1)

Aminopeptidase (1)

Free radical scavengers (1)

hCE (1)

Pyroptosis (1)

Methionine Adenosyltransferase (MAT) (1)

Hippo pathway (1)

CRISPR/Cas9 (1)

Adenosine deaminase (1)

Complement System (1)

DAPK (1)

Gap Junction Protein (1)

Neurokinin receptor (1)

NADPH-oxidase (1)

IRAK (1)

Sigma receptor (1)

CFTR (1)

PKM (1)

化合物库信息示例

Empty	1000025-07-9	1000413-72-8	229005-80-5	1000787-75-6	946387-07-1	1000998-59-3	1175526-27-8	1001288-58-9	1001350-96-4	1001404-83-6	Empty
Empty	Vadadustat	TAK875	TAK-779	Tegobuvir	RN-1734	BMS-687453	AM211	FT011	BMS754807	AAI101	Empty
Empty	1001625-82-6	1001645-58-4	1001753-24-7	1001908-89-9	1002304-34-8	1002-84-2	100291-86-9	100299-08-9	10030-52-1	10040-45-6	Empty
Empty	RPW-24	SRT1720 hydrochloride	INH6	SRT 2183	AMG208	Pentadecanoic acid	Apiopaeonoside	Pemirolast potassium	L-Anserine nitrate salt	Sodium Picosulfate	Empty
Empty	100427-26-7	1004316-88-4	10045-45-1	100462-37-1	1004990-28-6	100-51-6	1005-24-9	1005264-47-0	1005334-57-5	1005342-46-0	Empty
Empty	Lercanidipine	Cobicistat	1-Ethyl-2-benzimidazolinone	ROSIRIDIN	PF-AKT400	Benzyl alcohol	1-Methylnicotinamide chloride	MX69	CVT-10216	LCL161	Empty
Empty	1005491-05-3	100-55-0	1005504-62-0	1005883-72-6	100643-71-8	1007207-67-1	10075-50-0	1007647-73-5	100784-20-1	10083-24-6	Empty
Empty	Tirasemtiv	Roniacol	Rg3039	Z433927330	Desloratadine	CH5132799	5-Bromoindole	Smurf1-IN-A01	Halosulfuron-methyl	Piceatannol	Empty
Empty	100872-83-1	100874-08-6	1009119-64-5	1009119-65-6	100929-71-3	1009298-09-2	1009298-59-2	100929-99-5	1009734-33-1	10097-84-4	Empty
Empty	ML346	SB 4	Daclatasvir	Daclatasvir dihydrochloride	NADPH (tetracyclohexanamine)	AZD8055	Vistusertib	PAβN dihydrochloride	HZ1157	Rotundine	Empty
Empty	1009816-48-1	1009817-63-3	1009820-21-6	100986-85-4	101001-34-7	1010411-21-8	1010-60-2	1011244-68-0	1011301-27-1	1011529-10-4	Empty
Empty	Thiamet G	B-AP15	Silmitasertib	Levofloxacin	Pamicogrel	GSK369796 Dihydrochloride	2-Chloronaphthoquinone	TFAP	Tenovin3	Azvudine	Empty
Empty	101152-94-7	101155-02-6	1011557-82-6	1011-74-1	101-20-2	1012054-59-9	101-21-3	101-26-8	101303-98-4	1013101-36-4	Empty
Empty	Milnacipran hydrochloride	BW-A78U	Tenovin-6	DL-Normetanephrine hydrochloride	Triclocarban	CUDC101	Chlorpropham	Mestinon	Zacopride hydrochloride	PF04691502	Empty
Empty	101-31-5	1013-69-0	1013750-77-0	1013753-99-5	10138-52-0	1013920-15-4	1013937-63-7	1014691-61-2	101477-54-7	101494-95-5	Empty
Empty	L-Hyoscyamine	Noreugenin	ML-030	BC-1382	Gadolinium chloride	Vorolanib	VTP-27999 TFA	GSK0660	Lomerizine hydrochloride	8-CHLOROQUINAZOLIN-4(1H)-ONE	Empty

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