SLAMF7 Protein, Human, Recombinant (mFc)

SLAMF7 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with C-mFc tag. The predicted molecular weight is 60-90 KDa and the accession number is Q9NQ25.

规格	价格/CNY		数量
10 μg	￥ 360	5日内发货
50 μg	￥ 1,100	5日内发货
500 μg	￥ 8,900	5日内发货
1 mg	￥ 13,300	5日内发货

规格

价格/CNY

货期

数量

10 μg

￥ 360

5日内发货

50 μg

￥ 1,100

5日内发货

500 μg

￥ 8,900

5日内发货

1 mg

￥ 13,300

5日内发货

产品描述	SLAMF7 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with C-mFc tag. The predicted molecular weight is 60-90 KDa and the accession number is Q9NQ25.

种属	Human
表达系统	HEK293 Cells
标签	C-mFc
蛋白编号	Q9NQ25
别名	CD2 Subset 1, CRACC, CD319, CS1, Membrane Protein FOAP-12, SLAMF7, Protein 19A, SLAM Family Member 7, Novel Ly9, CD2-Like Receptor-Activating Cytotoxic Cells
氨基酸序列	Ser23-Met226
蛋白构建	Ser23-Met226
蛋白纯度	Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
分子量	60-90 KDa (reducing condition)

内毒素	< 0.1 ng/µg (1 EU/µg) as determined by LAL test.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4.
复溶方法	Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
存储	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.
研究背景	SLAMF7 is a single-pass type I membrane protein and contains 1 Ig-like C2-type (immunoglobulin-like) domain. SLAMF7 is expressed in NK cells, activated B-cells, NK-cell line but not in promyelocytic, B-cell lines, or T-cell lines. Although the cytoplasmic domain of CS1 contains immunoreceptor tyrosine-based switch motifs (ITSM), which enables to recruite signaling lymphocyte activation molecule (SLAM)-associated protein (SAP/SH2D1A), it activates NK cells in the absence of a functional SAP. SLAMF7 positively regulated natural killer cell functions by a mechanism dependent on the adaptor EAT-2 but not the related adaptor SAP. However, in the absence of EAT-2, CRACC potently inhibited natural killer cell function. It was also inhibitory in T cells, which are typically devoid of EAT-2. Thus, SLAMF7 can exert activating or inhibitory influences on cells of the immune system depending on cellular context and the availability of effector proteins.

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SLAMF7 Protein, Human, Recombinant (mFc)

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