PCSK9 Protein, Human, Recombinant (Avi), Biotinylated is expressed in HEK293 mammalian cells with C-Avi tag. The predicted molecular weight is 19&65 KDa and the accession number is Q8NBP7.
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
20 μg | ¥ 2,260 | 5日内发货 | ||
100 μg | ¥ 6,130 | 5日内发货 |
产品描述 | PCSK9 Protein, Human, Recombinant (Avi), Biotinylated is expressed in HEK293 mammalian cells with C-Avi tag. The predicted molecular weight is 19&65 KDa and the accession number is Q8NBP7. |
种属 | Human |
表达系统 | HEK293 Cells |
标签 | C-Avi |
蛋白编号 | Q8NBP7 |
别名 | Subtilisin/Kexin-Like Protease PC9, PC9, NARC-1, Proprotein Convertase Subtilisin/Kexin Type 9, NARC1, PCSK9, Neural Apoptosis-Regulated Convertase 1, Proprotein Convertase 9 |
氨基酸序列 | Gln31-Gln692(Val474Ile,Gly670Glu) |
蛋白构建 | Gln31-Gln692(Val474Ile,Gly670Glu) |
蛋白纯度 | Greater than 95% as determined by reducing SDS-PAGE. (QC verified) |
分子量 | 19&65 KDa (reducing condition) |
内毒素 | < 0.1 ng/µg (1 EU/µg) as determined by LAL test. |
缓冲液 | Supplied as a 0.2 μm filtered solution of 50 mM HEPES, 150 mM NaCl, 20% Glycerol, pH 7.4. |
存储 |
Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
运输方式 |
In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice. |
研究背景 | Human Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) is a secretory subtilase belonging to the proteinase K subfamily. PCSK9 is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the ER , the pro domain and mature chain secrete together through noncovalent interactions. PCSK9 binds with low-density lipoprotein receptor (LDLR) and plays a major regulatory role in cholesterol homeostasis. Inhibition of PCSK9 function by preventing PCSK9/LDLR interaction is currently being explored as a means of lowering cholesterol levels. PCSK9 also binds to apolipoprotein receptor 2 (ApoER2), and play a role in the neural development. |
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PCSK9 Protein, Human, Recombinant (Avi), Biotinylated PCSK 9 Subtilisin/Kexin-Like Protease PC9 PC9 PCSK-9 NARC-1 Proprotein Convertase Subtilisin/Kexin Type 9 PC-9 NARC 1 NARC1 PCSK9 Neural Apoptosis-Regulated Convertase 1 PC 9 Proprotein Convertase 9 recombinant recombinant-proteins proteins protein