CD117 Protein, Human, Recombinant (hFc)

C-Kit/SCF R is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). c-Kit contains 5 Ig-like C2-type (immunoglobulin-like) domains and 1 protein kinase domain. It belongs to the protein kinase superfamily and CSF-1/PDGF receptor subfamily. SCF R expression on mast cells enables them to infiltrate SCF-secreting tumors where they promote tumor growth and induce local immune suppression. SCF R is up-regulated on dendritic cells by Th2-orTh17-biasing stimuli, and it is required for subsequent dendritic cell induction of Th2 and Th17 responses. SCF R protects vascular smooth muscle cells from apoptosis and assists in the recovery of cardiac function following myocardial infarction.

规格	价格/CNY		数量
10 μg	￥ 410	5日内发货
50 μg	￥ 1,270	5日内发货
500 μg	￥ 10,600	5日内发货
1 mg	￥ 16,000	5日内发货

规格

价格/CNY

货期

数量

10 μg

￥ 410

5日内发货

50 μg

￥ 1,270

5日内发货

500 μg

￥ 10,600

5日内发货

1 mg

￥ 16,000

5日内发货

产品描述

种属	Human
表达系统	HEK293 Cells
标签	C-hFc
蛋白编号	P10721
别名	KIT, CD117, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog, p145 c-kit, SCFR, Tyrosine-protein kinase Kit, Proto-oncogene c-Kit, Mast/stem cell growth factor receptor Kit, PBT, Piebald trait protein
氨基酸序列	Gln26-Thr520
蛋白构建	Gln26-Thr520
蛋白纯度	Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
分子量	100-140 kDa (reducing condition)

内毒素	< 0.1 ng/µg (1 EU/µg) as determined by LAL test.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4.
复溶方法	Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
存储	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.
研究背景	C-Kit/SCF R is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). c-Kit contains 5 Ig-like C2-type (immunoglobulin-like) domains and 1 protein kinase domain. It belongs to the protein kinase superfamily and CSF-1/PDGF receptor subfamily. SCF R expression on mast cells enables them to infiltrate SCF-secreting tumors where they promote tumor growth and induce local immune suppression. SCF R is up-regulated on dendritic cells by Th2-orTh17-biasing stimuli, and it is required for subsequent dendritic cell induction of Th2 and Th17 responses. SCF R protects vascular smooth muscle cells from apoptosis and assists in the recovery of cardiac function following myocardial infarction.

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CD117 Protein, Human, Recombinant (hFc)

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