Galectin

Galectins are a class of proteins that bind specifically to β-galactoside sugars, such as N-acetyllactosamine (Galβ1-3GlcNAc or Galβ1-4GlcNAc), which can be bound to proteins by either N-linked or O-linked glycosylation. They are also termed S-type lectins due to their dependency on disulphide bonds for stability and carbohydrate binding. There have been about 15 galectins discovered in mammals, encoded by the LGALS genes, which are numbered in a consecutive manner. Only galectin-1, -2, -3, -4, -7, -7B, -8, -9, -9B, 9C, -10, -12, -13, -14, and -16 have been identified in humans. Galectin-5 and -6 are found in rodents, whereas galectin-11 and -15 are uniquely found in sheep and goats. Members of the galectin family have also been discovered in other mammals, birds, amphibians, fish, nematodes, sponges, and some fungi. Unlike the majority of lectins they are not membrane bound, but soluble proteins with both intra- and extracellular functions. They have distinct but overlapping distributions[2] but found primarily in the cytosol, nucleus, extracellular matrix or in circulation. Although many galectins must be secreted, they do not have a typical signal peptide required for classical secretion. The mechanism and reason for this non-classical secretion pathway is unknown.

Cat. No.	Product Name	CAS No.	Purity
T79380	Galectin-3/galectin-8-IN-1 化合物 Galectin-3/galectin-8-IN-1		98%
T79380	Galectin-3/galectin-8-IN-1 (Compound 53) 是抑制Galectin-3和galectin-8C末端结构域的双重抑制剂，其Kd值分别为4.12 μM和6.04 μM。该化合物有效抑制MRC-5肺成纤维细胞的迁移，可用于癌症和组织纤维化的研究。
T79381	Galectin-3/galectin-8-IN-2 化合物 Galectin-3/galectin-8-IN-2		98%
T79381	Galectin-3/galectin-8-IN-2（Compound 57）是一种针对Galectin-3和galectin-8C末端结构域的双重抑制剂，其Kd值分别为12.8 μM和2.06 μM。该化合物能够抑制MRC-5肺成纤维细胞的迁移，适用于癌症和组织纤维化研究领域。
T82605	DB21, Galectin-1 Antagonist 化合物 DB21, Galectin-1 Antagonist	1623027-80-4	98%
T82605	DB21, Galectin-1 Antagonist 是一种用于抑制galectin-1 (GAL1)与细胞表面聚糖结合的二苯并呋喃缀合肽模拟物。在黑色素瘤、肺腺癌和卵巢癌模型中，该化合物能增强血管生成和肿瘤生长的抑制效果。
T74538	Galectin-3 antagonist 2 化合物 Galectin-3 antagonist 2	2921603-02-1	98%
T74538	Galectin-3，作为β-半乳糖苷特异性的识别蛋白（凝集素），具备促进B细胞前体急性淋巴细胞白血病（BCP-ALL）细胞迁移及耐受药物治疗的功能。
T38074	Thiodigalactoside 硫代半乳糖苷	51555-87-4	99.74%
T38074	Thiodigalactoside 是一种具有口服活性的，有效的半乳凝素 (GAL) 抑制剂，对于 GAL-1 和 GAL-3 的 Kd 值分别为 24 μM，49 μM。Thiodigalactoside 是一种不可代谢的二糖，具有抗炎和抗癌活性。Thiodigalactoside 可显着降低饮食诱发的肥胖大鼠的体重增...
T5121	TD139 化合物TD139	1450824-22-2	99.48%
T5121	TD139 是一种吸入型 galectin-3 抑制剂（Kd：14 nM）。
T16413	OTX008 化合物OTX008	286936-40-1	98.77%
T16413	OTX008 (PTX008) 是半乳糖凝集素 1 选择性抑制剂。
T15372	GB1107 化合物GB1107	1978336-61-6	98.33%
T15372	GB1107 是一种有效的选择性 Galectin-3 抑制剂，Kd 为 37 nM。
T11346L	G3-C12 acetate(848301-94-0 free base) 化合物G3-C12 acetate	T11346L	98%
T11346L	G3-C12 acetate(848301-94-0 free base) 显示出抗癌活性。是一种半乳糖凝集素 3 结合肽，Kd 为 88 nM。