||Urea is formed in the liver from ammonia produced by the deamination of amino acids. It is the principal end metabolite of protein catabolism and accounts for about one-half of the total urinary solids.
||WAY-262611 is a wingless β-Catenin agonist.
||ISX9 is necessary to activate neuron-specific genes as neurogenesis inducer.
||KY02111 facilitates differentiation of hPSCs to cardiomyocytes by inhibiting Wnt signaling, maybe affect downstream of GSK3β and APC.
||ICG-001 antagonizes Wnt/β-catenin/TCF-mediated transcription and specifically binds to element-binding protein (CREB)-binding protein (CBP) with IC50 of 3 μM, but is not the related transcriptional coactivator p300.
||FH535, a Wnt/β-catenin signaling and PPAR inhibitor, exhibits anti-tumor activities.
||IWR-1, a Wnt pathway inhibitor, stabilizes the Axin destruction complex(EC50=0.2 uM).
||IWP-2, an inhibitor of Wnt processing and secretion (IC50=27 nM) in a cell-free assay, selectively blocks Porcn-mediated Wnt palmitoylation.
||Methyl vanillate is Hovenia Dulcis Thunb extract and its ingredient methyl vanillate activate Wnt/β-catenin pathway and increase bone mass in growing or ovariectomized mice. Methyl vanillate is considered to be a slightly soluble (in water) acidic compound. Methyl vanillate can be synthesized from
||Wnt agonist 1 (BML-284)
||Wnt agonist 1 (BML-284) is a potent, selective and ,cell-permeable Wnt signaling activator.
||NCB-0846 is an orally active TNIK inhibitor (IC50: 21?nM).
||ETC-159 is a potent, orally available PORCN inhibitor. It inhibits β-catenin reporter activity with an IC50 of 2.9 nM.
||IWP-4 is a potent Wnt inhibitor.
||KYA1797K is a highly potent and selective inhibitor. Wnt/β-catenin IC50 is 0.75 μM through TOPflash assay.
||SKL2001, an agonist of the Wnt/β-catenin pathway, can disrupt the Axin/β-catenin interaction.
||iCRT3 is a Wnt and β-catenin-responsive transcription inhibitor.