||Zidovudine is a synthetic dideoxynucleoside. After intracellular phosphorylation to its active metabolite, zidovudine inhibits DNA polymerase, resulting in the inhibition of DNA replication and cell death. This agent also decreases levels of available pyrimidines.
||BIBR 1532 is an effective, specific and non-competitive telomerase inhibitor (IC50: 100 nM, in a cell-free assay).
||RHPS4 is a potent inhibitor of Telomerase at submicromolar.
||Costunolide has anti-inflammatory and anti-oxidant properties and mediates apoptosis.
||Cycloastragenol is able to elongate telomeres, resulting in increased lifespan of the animals.