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TRP/TRPV Channel
T2007 RQ00203078 RQ-00203078 is a highly selective, potent and orally available TRPM8 antagonist.
T2170 SKF-96365 hydrochloride SKF-96365, a SOCE inhibitor, exhibits potent anti-neoplastic activity by inducing cell-cycle arrest and apoptosis in colorectal Y cells. SKF-96365 can induce cytoprotective autophagy to delay apoptosis by preventing the release of cytochrome c (cyt c) from the mitochondria into the cytoplasm. Mechan
T4385 PF-4840154 PF-4840154 is a potent, selective agonist of the rat and human TrpA1 channel and elicited TrpA1-mediated nocifensive behaviour in mouse, with EC50 of 97 nM and 23 nM for rTrpA1 and hTrpA1, respectively.
T2994 Cardamonin Cardamomin (also known as cardamonin) is a chalconoid that has been isolated from several plants including Alpinia katsumadai and Alpinia conchigera. It is a novel antagonist of hTRPA1 cation channel with an IC50 of 454 nM. It has received growing attention from the scientific community due to the e
T4028 ML329 ML329 is a small molecule inhibitor of MITF, inhibiting TRPM-1 promoter activity.
T1321 Nonivamide Nonivamide is found in herbs and spices. Nonivamide is an alkaloid from Capsicum species Nonivamide is a flavoring ingredient. Nonivamide is an organic compound and a capsaicinoid. It is an amide of pelargonic acid and vanillylamine. It is present in chili peppers, but is commonly manufactured synth
T2711 TCS 5861528 TCS5861528 is a TRPA1 channel blocker that antagonizes AITC- and 4-HNE-evoked calcium influx with IC50 values of 14.3 and 18.7 μM, respectively.
T6617 Optovin Optovin is a TRPA1 activator, which is reversibly photoactivated.
T6530 HC-030031 HC-030031 is a potent TRPA1 inhibitor, which antagonizes AITC- and formalin-evoked calcium influx with IC50s of 6.2±0.2 and 5.3±0.2 μM, respectively.
T1814 ICILIN Icilin(AG 3-5) is a synthetic TRPM8 ion channel super-agonist.
T1062 Capsaicin Capsaicin is an active component of chili peppers. It selectively binds to TRPV1 which is a heat-activated calcium channel. Capsaicin causes the channel to open below 37 °C This is why capsaicin is linked to the sensation of heat.
T0882 (+)-Camphor (+)-Camphor is the oil extracted from the wood of the Camphor tree Cinnamomum Camphora with anti-inflammatory and analgesic properties.
T6977 SB366791 SB-366791 is a new and selective cinnamide TRPV1 antagonist.
T2845 Imperatorin Imperatorin is a modulator of p38,ERK pathway. Imperatorin increases BMP-2 expression (mRNA) and increases bone density/volume and mineralization in vivo.
T6660 SB705498 SB705498 is a TRPV1 antagonist for hTRPV1. SB-705498 has been investigated for the treatment of Rhinitis, Chronic Cough, and Non-allergic Rhinitis.
T2298 ML204 ML204 is a novel potent antagonist that selectively modulates native TRPC4/C5 ion channels.
T0457 Probenecid Probenecid is a benzoic acid derivative with antihyperuricemic property.
T0647 Tryptamine Tryptamine is a monoamine alkaloid found in animals, plants, and fungi. It contains an indole ring structure and is structurally analogous to the tryptophan. It is found in trace amounts in the brains of mammals and is recognized to play a role as a neurotransmitter or neuromodulator.
T6379 AMG-517 AMG 517 is an effective and specific TRPV1 antagonist, antagonizes proton (IC50: 0.76 nM), capsaicin (IC50: 0.62 nM), and heat activation (IC50: 1.3 nM) of TRPV1.
T3727 Methyl syringate Methyl syringate has a unique inhibitory activity toward aflatoxin production with a different mode of action from that of gallic acid. Methyl syringate from K. pictus is a specific and selective activator of hTRPA1, can regulate food intake and gastric emptying through a TRPA1-mediated pathway and,
T6848 GSK1016790A GSK1016790A (GSK101) is a novel, potent activator of TRPV4 (transient receptor potential vanilloid 4) with EC50 of 34nM in choroid plexus epithelial cells.
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