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Sirtuin
T2412 SRT 1720 Hydrochloride SRT1720 hydrochloride is a selective activator of human SIRT1.
T1873 Tenovin-3 Tenovin-3 is a p53 activator.
T1818 Tenovin-6 Tenovin-6 is a p53 transcriptional activity agonist.
T6679 SRT2104 (GSK2245840) SRT2104 (GSK2245840) is a selective and brain-permeable SIRT1 activator.
T3953 Salermide Salermide is an inhibitor of Sirt1 and Sirt2, causing strong cancer-specific apoptotic cell death.
T4108 3-TYP 3-TYP is a selective?SIRT3?inhibitor.
T3447 Thiomyristoyl Thiomyristoyl is an effective and selective SIRT2 inhibitor (IC50: 28 nM). It inhibits SIRT1 (IC50: 98 μM) but no effect on SIRT3 even at 200 μM.
T4019 Cambinol Cambinol is a cell-permeable b-naphthol compound that inhibits the NAD-dependent deacetylase activity of SIRT1/2 (IC50: 56/59 μM, respectively) in a substrate-, but not NAD-, competitive manner. Cambinol inhibits SIRT5 deacetylase activity only at much higher concentrations (IC50 >300 μM) and no i
T6371 AGK2 AGK2(IC50=3.5 μM) is an effective, and specific SIRT2 inhibitor.
T1887 Inauhzin Inauhzin(INZ) is a novel small molecule that effectively reactivates p53 by inhibiting SIRT1 activity, promotes p53-dependent apoptosis of human Y cells without causing apparently genotoxic stress(IC50=3 uM, in A549 cell).
T4062 CAY10602 CAY10602 is a SIRT1 activator. CAY10602 was derived from high throughput screening for compounds that increase SIRT1-mediated deacetylation of a SIRT1-specific substrate. Functional assays show that CAY10602 dose-dependently suppresses the NF-κB-dependent induction of TNF-α by lipopolysaccharide i
T6671 Sirtinol Sirtinol is a selective SIRT1/2 inhibitor (IC50: 131/38 μM).
T6111 EX 527 EX 527 is an effective and specific SIRT1 inhibitor (IC50: 38 nM), shows >200-fold selectivity against SIRT2/3.
T1558 Resveratrol Resveratrol is a polyphenolic phytoalexin with antioxidant and potential chemopreventive activities.
T2879 Fisetin Fisetin (Fustel), an agent extracted from Rhus succedanea L, can modulate sirtuins.
T6678 Splitomicin Splitomicin (IC50 of 60 μM), a specific inhibitor of NAD(+)-dependent histone deacetylase Sir2p, displays a high activity in a cell-based assay.
T6984 SirReal2 SirReal2 is a potent and selective Sirt2 inhibitor with IC50 of 140 nM.
T4328 OSS128167 OSS_128167 is a specific SIRT6 inhibitor, and for SIRT6(IC50=89 μM), SIRT1(IC50=1578 μM) and SIRT2(IC50=751 μM).
T0934 Nicotinamide Niacinamide is an important compound functioning as a component of the coenzyme NAD. Its primary significance is in the prevention and/or cure of blacktongue and PELLAGRA. Most animals cannot manufacture this compound in amounts sufficient to prevent nutritional deficiency and it therefore must be s
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