||SRT 1720 Hydrochloride
||SRT1720 hydrochloride is a selective activator of human SIRT1.
||Tenovin-3 is a p53 activator.
||Tenovin-6 is a p53 transcriptional activity agonist.
||SRT2104 (GSK2245840) is a selective and brain-permeable SIRT1 activator.
||Salermide is an inhibitor of Sirt1 and Sirt2, causing strong cancer-specific apoptotic cell death.
||3-TYP is a selective?SIRT3?inhibitor.
||Thiomyristoyl is an effective and selective SIRT2 inhibitor (IC50: 28 nM). It inhibits SIRT1 (IC50: 98 μM) but no effect on SIRT3 even at 200 μM.
||Cambinol is a cell-permeable b-naphthol compound that inhibits the NAD-dependent deacetylase activity of SIRT1/2 (IC50: 56/59 μM, respectively) in a substrate-, but not NAD-, competitive manner. Cambinol inhibits SIRT5 deacetylase activity only at much higher concentrations (IC50 >300 μM) and no i
||AGK2（IC50=3.5 μM） is an effective, and specific SIRT2 inhibitor.
||Inauhzin(INZ) is a novel small molecule that effectively reactivates p53 by inhibiting SIRT1 activity, promotes p53-dependent apoptosis of human Y cells without causing apparently genotoxic stress(IC50=3 uM, in A549 cell).
||CAY10602 is a SIRT1 activator. CAY10602 was derived from high throughput screening for compounds that increase SIRT1-mediated deacetylation of a SIRT1-specific substrate. Functional assays show that CAY10602 dose-dependently suppresses the NF-κB-dependent induction of TNF-α by lipopolysaccharide i
||Sirtinol is a selective SIRT1/2 inhibitor (IC50: 131/38 μM).
||EX 527 is an effective and specific SIRT1 inhibitor (IC50: 38 nM), shows >200-fold selectivity against SIRT2/3.
||Resveratrol is a polyphenolic phytoalexin with antioxidant and potential chemopreventive activities.
||Fisetin (Fustel), an agent extracted from Rhus succedanea L, can modulate sirtuins.
||Splitomicin (IC50 of 60 μM), a specific inhibitor of NAD(+)-dependent histone deacetylase Sir2p, displays a high activity in a cell-based assay.
||SirReal2 is a potent and selective Sirt2 inhibitor with IC50 of 140 nM.
||OSS_128167 is a specific SIRT6 inhibitor, and for SIRT6(IC50=89 μM), SIRT1(IC50=1578 μM) and SIRT2(IC50=751 μM).
||Niacinamide is an important compound functioning as a component of the coenzyme NAD. Its primary significance is in the prevention and/or cure of blacktongue and PELLAGRA. Most animals cannot manufacture this compound in amounts sufficient to prevent nutritional deficiency and it therefore must be s