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Serine Protease
T1791 LDK378(Ceritinib) Ceritinib is a Kinase Inhibitor. The mechanism of action of Ceritinib is as a Tyrosine Kinase Inhibitor, and Cytochrome P450 3A Inhibitor, and Cytochrome P450 2C9 Inhibitor.
T6564 Leupeptin Hemisulfate Leupeptin hemisulfate is a reversible, competitive serine/cysteine protease inhibitor. It is an orally active, antioxidant and anti-inflammatory agent.
T6986 Sivelestat Sivelestat is a potent and selective inhibitor of neutrophil elastase with IC50 of 44 nM.
T3990 AA26-9 AA26-9 is an effective and broad-spectrum inhibitor of serine hydrolase.
T3423 ML281 ML281 is a potent and selective STK33 inhibitor with IC50 of 14 nM.
T0175 Amiloride hydrochloride Amiloride hydrochloride is an effective sodium channel blocker of epithelial.
T1954 SRPIN340 SRPIN340, a serine/arginine-rich protein kinase (SRPK)-specific inhibitor, is potent for SRPK1 (IC50 = 0.89 uM).
T3442 UK-371804 UK-371804 is an effective and specific uPA inhibitor. It was selected as a candidate for further preclinical evaluation for the treatment of chronic dermal ulcers.
T6370 AEBSF hydrochloride against HIV-1.
T0789 PMSF Phenylmethanesulfonyl fluoride (PMSF) is an enzyme inhibitor that inactivates IRC-50 arvin, subtilisin, and the fatty acid synthetase complex.
T2118 SC-514 SC-514 is a selective, orally active, ATP-competitive IKK-2 inhibitor (IC50=11.2±4.7 μM), obstructs NF-κB-dependent gene expression.
T0372 Gabexate mesylate Gabexate mesylate is a serine proteinase inhibitor used therapeutically in the treatment of pancreatitis, disseminated intravascular coagulation (DIC), and as a regional anticoagulant for hemodialysis. The drug inhibits the hydrolytic effects of thrombin, plasmin, and kallikrein, but not of chymotry
T2392 Nafamostat mesylate Nafamostat mesylate, a synthetic serine protease inhibitor,has been used for the treatment of allergic disorders such as asthma, allergic rhinitis and atopic dermatitis.
T3107 Alvelestat Alvelestat is an orally bioavailable, selective and reversible inhibitor of human neutrophil elastase (NE), with potential anti-inflammatory activity.
T1145 Diminazene Aceturate Diminazene is a trypanocidal agent.
T3359 Aprotinin Aprotinin a broad-spectrum serine protease inhibitor, inhibiting the activity of a number of different esterases and proteases, including trypsin, chymotrypsin, kallikrein, plasmin, tissue plasminogen activator, and tissue and leukocytic proteinases.
T6285 GSK690693 GSK690693 is a pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 2 nM/13 nM/9 nM, also sensitive to the AGC kinase family: PKA, PrkX and PKC isozymes. Phase 1.
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