Cat. No. | Product Name | CAS No. | Purity | Chemical Structure |
---|---|---|---|---|
TN1631 | Eupalinolide K
野马追内酯 K
|
108657-10-9 |
|
|
Eupalinolide K 是来自野马追的一种倍半萜内酯,是 STAT3抑制剂,可作为迈克尔反应受体。 | ||||
TN1840 | Kurarinol
苦参醇
|
855746-98-4 | 98% |
|
Kurarinol is a potent inhibitor of sortase A, with an IC50 value of 107.7 ± 6.6 μM. Kurarinol has extremely strong tyrosinase inhibitory activity, exerts varying... | ||||
T78983 | STAT3 degrader-2
化合物 STAT3 degrader-2
|
2497583-03-4 | 98% |
|
STAT3degrader-2为基于PROTAC技术的STAT3降解剂,能有效下调总STAT3蛋白水平, 适用于癌症等病理条件的研究。 | ||||
T79185 | STAT6-IN-2
化合物 STAT6-IN-2
|
1355594-85-2 | 98% |
|
STAT6-IN-2 (Comp R-84) 是STAT6的一种抑制剂,能够抑制嗜酸粒细胞趋化因子-3的分泌,常用于免疫疾病研究。 | ||||
T79186 | STAT6-IN-3
化合物 STAT6-IN-3
|
371919-80-1 | 98% |
|
STAT6-IN-3 (Compound 18a),一种针对STAT6的Src同源2 (SH2) 结构域的抑制剂,具有44 nM的IC50值。该化合物主要适用于研究哮喘等炎症性疾病。 | ||||
T79662 | STAT3-IN-20
化合物 STAT3-IN-20
|
2768427-54-7 | 98% |
|
STAT3-IN-20(Compound 40)是一种选择性地靶向STAT3的SH2结构域,展现了在DU145和MDA-MB-231癌细胞中的抗增殖效果(IC50分别为2.97 μM和3.26 μM),并诱导细胞周期停滞与细胞凋亡。该抑制剂有效抑制了STAT3的磷酸化、核内易位及其下游基因的转录活性(IC50: 0.65... | ||||
T80639 | HJC0152 free base
化合物 HJC0152 free base
|
1420290-88-5 | 98% |
|
HJC0152 (free base) 是一种口服活性的有效STAT3抑制剂,能够抑制细胞周期进程并诱导细胞凋亡(apoptosis)。此外,HJC0152 (free base) 在小鼠体内显著抑制MDA-MB-231 异种移植瘤的生长。 | ||||
T80847 | W1131 TFA
化合物 W1131 TFA
|
98% |
|
|
W1131 TFA 是一种抑制STAT3并诱导铁死亡(ferroptosis)的有效化合物。在胃癌的皮下异种移植模型、类器官模型以及PDX模型中,它都能显著阻止疾病的发展。此外,W1131能有效缓解癌细胞对5-FU的化学耐药性。该化合物还通过调节IL6-JAK-STAT3和铁死亡(ferroptosis)通路来影响细胞周... | ||||
T81690 | Neocucurbitacin A
化合物 Neocucurbitacin A
|
352359-53-6 | 98% |
|
Neocucurbitacin A (compound 7)是一种从沉香果皮提取的STAT3抑制剂,常用于抗癌研究。 | ||||
T14925 | Cenisertib
化合物 T14925
|
871357-89-0 | 98% |
|
Cenisertib 是一种有效的 ATP 竞争性的多激酶抑制剂,对 Aurora-kinase-A/B,ABL1,AKT,STAT5, FLT3 的活性具有抑制作用,对FER 及其同源物的激酶也显示出抑制作用。Cenisertib 通过抑制肿瘤肥大细胞 (MC) 中几种不同分子靶标的活性抑制其生长,也抑制异种移植模型中... | ||||
TN4035 | Eupalinolide I
化合物 TN4035
|
1402067-84-8 | 98% |
|
Eupalinolide I is a natural product from Eupatorium lindleyanum. | ||||
TN3587 | Capillarisin
化合物 TN3587
|
56365-38-9 | 98% |
|
Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in negative regulation of growth, metastasis, and chemoresistance of tumor cell... | ||||
T13010 | STAT3-IN-3
化合物 T13010
|
2361304-26-7 | 98% |
|
STAT3-IN-3 is a potent and selective signal transducer inhibitor and transcription 3 (STAT3) activator. | ||||
TN3410 | Anatabine
化合物 TN3410
|
581-49-7 | 98% |
|
Anatabine shows anti-inflammatory activity in vitro and in vivo, which is mediated in part via an inhibition of STAT3 phosphorylation.Anatabine has anti-Alzheime... | ||||
TN3525 | Boehmenan
化合物 TN3525
|
57296-22-7 | 98% |
|
(±)-Boehmenan shows potent protein-tyrosine phosphatase 1B (PTP1B) inhibitory activity in vitro with the IC(50) values of 43.5 uM, it inhibits PTP1B activity in ... | ||||
TN2511 | Britannilactone diacetate
化合物 TN2511
|
1286694-67-4 | 98% |
|
1,6-O,O-Diacetylbritannilactone(OODBL) has anti-inflammatory activity, it has a potential therapeutic efficacy on inflammatory diseases especially allergic airwa... | ||||
T11449L2 | Golotimod (TFA) (229305-39-9 free base)
化合物 T11449L2
|
T11449L2 | 98% |
|
Golotimod (TFA), an immunomodulating peptide with antimicrobial activity, significantly increases the efficacy of antituberculosis therapy, stimulates thymic and... | ||||
TN4774 | Physalin A
化合物 TN4774
|
23027-91-0 | 98% |
|
Physalin A exerts anti-tumor activity in non-small cell lung cancer cell lines by suppressing JAK/STAT3 signaling, it inhibits androgen-independent prostate canc... | ||||
T12905 | SI-109
化合物 T12905
|
T12905 | 98% |
|
SI-109 is a potent inhibitor of STAT3 SH2 domain (Ki=9 nM),and with antitumor activity. | ||||
T19886 | Cirsilineol
甲基条叶蓟素
|
41365-32-6 | 98% |
|
Cirsilineol (Eupatrin) 是从 Artemisia vestita Wall 的草本植物中分离出来的,具有免疫抑制、抗增殖和抗肿瘤特性。 Cirsilineol 通过线粒体途径选择性诱导细胞凋亡。 |