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T6995 STA-21 STA-21 is a selective STAT3 inhibitor.
T6537 HO-3867 HO-3867, an analog of curcumin, is a sspecific STAT3 inhibitor.
T3398 Icaritin Icaritin has hormone regulation activity and cardiovascular function improvement activity. Icaritin has anticancer activity, can induce S phase arrest and apoptosis, inhibit ENKL cell proliferation. Icaritin has anti-multiple myeloma activity, mainly mediated by inhibiting IL-6/JAK2/STAT3 signaling.
T3708 BP-1-102 BP-1-102 is an orally active, effective and specific STAT3 inhibitor. BP-1-102 binds Stat3 (Kd: 504 nM), then blocks Stat3-phosphotyrosine (pTyr) peptide interactions and Stat3 activation (4-6.8 μM), and selectively inhibits migration, survival, growth, and invasion of Stat3-dependent tumor cells.
T4234 HJC0152 HJC0152 is a signal transducer and activator of transcription 3 (STAT3) inhibitor.
T6669 SH-4-54 SH-4-54 is a most potent, small molecule, nonphosphorylated STAT3 inhibitor.
T6308 Stattic Stattic is a potent inhibitor of STAT3, used for cancer treatment.
T4034 Solamargine Solamargine is a major steroidal alkaloid glycoside extracted from a traditional Chinese medicine herb, Solanum nigrum L. (SNL); has been shown to inhibit growth and induce apoptosis of various cancer cells.
T3913 Saikosaponin D Saikosaponin D is a novel SERCA inhibitor by inhibiting NF-κB and STAT3 signaling to protect against acetaminophen-induced hepatotoxicity.
T1038 Fludarabine Fludarabine is a Nucleoside Metabolic Inhibitor. The mechanism of action of fludarabine is as a Nucleic Acid Synthesis Inhibitor.
T3380 Homoharringtonine Homoharringtonine is an alkaloid inhibitor of protein synthesis with activity in myeloid malignancies. It might have clinical activity in some patients with myelodysplastic syndrome. Homoharringtonine enhances the paracellular permeability of Caco-2 cell monolayers by modulating the protein expressi
T4216 STAT5 Inhibitor STAT5 Inhibitor is a cell-permeable inhibitor which suppresses Stat5 via binding to the SH2 domain.
T2814 Cryptotanshinone Cryptotanshinone, a STAT3 inhibitor (IC50: 4.6 μM) in a cell-free assay, strongly inhibits phosphorylation of STAT3 Tyr705, with a little effect on STAT3 Ser727, but no inhibition for STAT1 nor STAT5.
T3971 Casin CASIN is a specific inhibitor of GTPase Cdc42 (IC50: 2 uM).
T2505 NSC 74859 S3I-201 shows effective inhibition of STAT3 DNA-binding activity (IC50: 86 μM) in cell-free assays and low effect towards STAT1/5.
T0711 Niclosamide Niclosamide(BAY2353) is used to treat most tapeworm infections by inhibiting DNA replication.
T3404 Cucurbitacin B Cucurbitacin B has profound in vitro and in vivo antiproliferative effects against human pancreatic Y cells. It inhibited AKT signaling activation through up-regulation of PTEN. Cucurbitacin B is an effective inhibitor of HIF-1 and provide new perspectives into the mechanism of its anticancer activi
T2168 2-NP 2-NP is a STAT1 enhancer.
T3218 Napabucasin Napabucasin is an orally available Stat3 and Y cell stemness inhibitor.
T2156 WP1066 WP1066 is a inhibitor of JAK2 (IC50: 2.30 μM) and STAT3 (IC50: 2.43 μM) in HEL cells; shows activity to JAK2, STAT3/5, and ERK1/2, not JAK1 and JAK3. WP1066 has been used in trials studying the treatment of Melanoma, Brain Cancer, Solid Tumors, and Central Nervous System Neoplasms.
T0433 Artesunate Artesunate is part of the artemisinin group of drugs that treat malaria. It is a semi-synthetic derivative of artemisinin that is water-soluble and may therefore be given by injection. It is on the World Health Organization's List of Essential Medicines.
T1563 Nifuroxazide Nifuroxazide is an orally available and cell-permeable nitrofuran-based antidiarrheal agent. It has the inhibitory effect against the activation of cellular STAT1/3/5 transcription.
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