||Fasudil is a potent inhibitor of ROCK1, PKA, PKC, and MLCK.
||Y-27632 2 hydrochloride is a selective ROCK1 (p160ROCK) inhibitor.
||Y-27632 is a selective ATP-competitive inhibitor of ROCK-I and ROCK-II.
||RKI-1447 is a potent inhibitor of ROCK1 and ROCK2. It has anti-invasive and antitumor activities.
||Capivasertib, a new-type orally available inhibitor of the serine/threonine protein kinase AKT (protein kinase B), has potential antineoplastic activity.
||RKI-1313 was a selective inhibitor for ROCK-dependent signaling, cytoskeletal changes, anchorage-independent colony formation, migration, and invasion.
||Thiazovivin (Tzv), a ROCK inhibitor (IC50: 0.5 μM), increases the survival rate of hESC after single-cell dissociation.
||Tofacitinib citrate (CP-690550 citrate) is a novel JAK3 inhibitor (IC50: 1 nM), 20- to 100-fold less potent against JAK2/1.
||AT13148 is an oral-active and ATP-competitive, multi-AGC kinase inhibitor for Akt1/2/3, p70S6K, PKA, and ROCKI/II.
||GSK429286A is a specific inhibitor of ROCK1/2 (IC50: 14/63 nM).
||Fasudil (HA-1077) hydrochloride
||Fasudil Hydrochloride is a potent inhibitor of ROCK1, PKA, PKC, and MLCK with Ki of 0.33 μM, 1.0 μM, 9.3 μM and 55 μM, respectively.
||GSK180736A is an effective and selective GRK2 inhibitor (IC50: 0.77 μM) and >100-fold selectivity over other GRKs. It is a weak inhibitor of PKA (IC50: 30 μM), but highly effective against ROCK1 (IC50: 100 nM).
||GSK269962 is a selective ROCK(Rho-associated protein kinase) inhibitor with IC50 values of 1.6 and 4 nM for ROCK1 and ROCK2, respectively.
||ZINC00881524 is an effective and specific ROCK inhibitor.
||URMC-099 is an orally bioavailable, brain penetrant MLK inhibitor (IC50: 19/42/14/150 nM, for MLK1/MLK2/MLK3/DLK), and also inhibits LRRK2 activity (IC50: 11 nM).
||Tofacitinib is an oral, small molecule inhibitor of Janus kinases that is used to treat moderate-to-severe rheumatoid arthritis.
||KD025 is an orally available, and specific ROCK2 inhibitor (IC50/Ki: 60/41 nM).
||Hydroxyfasudil hydrochloride is a ROCK1/2 inhibitor (IC50s: 0.73/0.72 μM).