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ROCK
T1606 Fasudil Fasudil is a potent inhibitor of ROCK1, PKA, PKC, and MLCK.
T1725 Y-27632 dihydrochloride Y-27632 2 hydrochloride is a selective ROCK1 (p160ROCK) inhibitor.
T1870 Y27632 Y-27632 is a selective ATP-competitive inhibitor of ROCK-I and ROCK-II.
T1898 RKI-1447 RKI-1447 is a potent inhibitor of ROCK1 and ROCK2. It has anti-invasive and antitumor activities.
T1920 AZD-5363 Capivasertib, a new-type orally available inhibitor of the serine/threonine protein kinase AKT (protein kinase B), has potential antineoplastic activity.
T2011 RKI-1313 RKI-1313 was a selective inhibitor for ROCK-dependent signaling, cytoskeletal changes, anchorage-independent colony formation, migration, and invasion.
T2155 Thiazovivin Thiazovivin (Tzv), a ROCK inhibitor (IC50: 0.5 μM), increases the survival rate of hESC after single-cell dissociation.
T2398 Tofacitinib citrate Tofacitinib citrate (CP-690550 citrate) is a novel JAK3 inhibitor (IC50: 1 nM), 20- to 100-fold less potent against JAK2/1.
T2482 AT13148 AT13148 is an oral-active and ATP-competitive, multi-AGC kinase inhibitor for Akt1/2/3, p70S6K, PKA, and ROCKI/II.
T2633 GSK429286A GSK429286A is a specific inhibitor of ROCK1/2 (IC50: 14/63 nM).
T3060 Fasudil (HA-1077) hydrochloride Fasudil Hydrochloride is a potent inhibitor of ROCK1, PKA, PKC, and MLCK with Ki of 0.33 μM, 1.0 μM, 9.3 μM and 55 μM, respectively.
T3513 GSK180736A GSK180736A is an effective and selective GRK2 inhibitor (IC50: 0.77 μM) and >100-fold selectivity over other GRKs. It is a weak inhibitor of PKA (IC50: 30 μM), but highly effective against ROCK1 (IC50: 100 nM).
T3518 GSK269962A GSK269962 is a selective ROCK(Rho-associated protein kinase) inhibitor with IC50 values of 1.6 and 4 nM for ROCK1 and ROCK2, respectively.
T4095 ZINC00881524 ZINC00881524 is an effective and specific ROCK inhibitor.
T6057 URMC-099 URMC-099 is an orally bioavailable, brain penetrant MLK inhibitor (IC50: 19/42/14/150 nM, for MLK1/MLK2/MLK3/DLK), and also inhibits LRRK2 activity (IC50: 11 nM).
T6321 Tofacitinib Tofacitinib is an oral, small molecule inhibitor of Janus kinases that is used to treat moderate-to-severe rheumatoid arthritis.
T6867 KD025 (SLx-2119) KD025 is an orally available, and specific ROCK2 inhibitor (IC50/Ki: 60/41 nM).
T4276 Hydroxyfasudil Hydrochloride Hydroxyfasudil hydrochloride is a ROCK1/2 inhibitor (IC50s: 0.73/0.72 μM).
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