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RAAS
T0180 Benazepril hydrochloride Benazepril is an angiotensin-converting enzyme (ACE) inhibitor widely used in the therapy of hypertension. Benazepril is associated with a low rate of transient serum aminotransferase elevations and has been linked to rare instances of acute liver injury.
T0215 Losartan potassium Losartan, an Angiotensin II Receptor Blocker, selectively and competitively blocks the binding of angiotensin II to the angiotensin I (AT1) receptor.
T0215L Losartan Losartan is an angiotensin II receptor antagonist.
T0706 Lisinopril dihydrate Lisinopril Dihydrate is an orally bioavailable, long-acting angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity.
T0805 Quinapril hydrochloride Quinapril is an angiotensin-converting enzyme (ACE) inhibitor used in the therapy of hypertension and congestive heart failure. Quinapril is associated with a low rate of transient serum aminotransferase elevations, but has yet to be linked to instances of acute liver injury.
T1057 Azilsartan Azilsartan is an Angiotensin 2 Receptor Blocker. The mechanism of action of azilsartan is as an Angiotensin 2 Type 1 Receptor Antagonist. The physiologic effect of azilsartan is by means of Decreased Blood Pressure.
T1461 Candesartan Candesartan is an angiotensin II receptor blocker used widely in the therapy of hypertension and heart failure.
T1462 Captopril Captopril is a potent and specific inhibitor of peptidyl-dipeptidase A. It blocks the conversion of angiotensin I to angiotensin II, a vasoconstrictor and important regulator of arterial blood pressure.
T1484 Perindoprilat Perindoprilat is an angiotensin-converting enzyme inhibitor.
T1484L Perindopril erbumine Perindopril Erbumine is the tert-butylamine salt of perindopril, the ethyl ester of a non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. Upon hydrolysis, perindopril erbumine is converted to its active form perindoprilat, inhibiting ACE and the conversion of
T1489 Fosinopril sodium Fosinopril sodium is a phosphinic acid-containing angiotensin-converting enzyme inhibitor that is effective in the treatment of hypertension. It is a prodrug that is converted to its active metabolite fosinoprilat.
T1518 Olmesartan medoxomil Olmesartan medoxomil is an angiotensin II type 1 receptor blocker that is used to manage hypertension.
T1520 Aliskiren hemifumarate Aliskiren Hemifumarate is an orally active nonpeptide renin inhibitor with antihypertensive activity.
T1570 Telmisartan Telmisartan is an Angiotensin 2 Receptor Blocker. The mechanism of action of telmisartan is as an Angiotensin 2 Receptor Antagonist.
T1605 Enalapril Enalapril is a dicarbocyl-containing peptide and angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity.
T1615 Irbesartan Irbesartan is an Angiotensin 2 Receptor Blocker. The mechanism of action of irbesartan is as an Angiotensin 2 Receptor Antagonist.
T1645 Ramipril Ramipril is a long-acting angiotensin-converting enzyme inhibitor. It is a prodrug that is transformed in the liver to its active metabolite ramiprilat.
T1940 BTB06584 BTB06584 is an IF1-dependent, selective inhibitor of the mitochondrial F1 Fo-ATPase. BTB06584 is a novel acetohydroxyacid synthase(AHAS) inhibitor, a promising drug target against Mycobacterium tuberculosis (MTB).
T2270 Trans-Tranilast Tranilast is an antiallergic drug developed by Kissei Pharmaceuticals. It was approved in 1982 for use in Japan and South Korea for bronchial asthma. Indications for keloid and hypertrophic scar were added in 1993. It has been used for the treatment of allergic disorders such as asthma, allergic rhi
T2318 LCZ696 LCZ696 is an orally bioavailable, dual angiotensin II receptor and neprilysin inhibitor for the treatment of hypertension and heart failure.
T2322 Fimasartan Fimasartan is a non-peptide angiotensin II receptor antagonist (ARB) used for the treatment of hypertension and heart failure. Concurrent administration of fimasartan with diuretic hydrochlorothiazide has shown to be safe in clinical trials.
T2400 Candesartan Cilexetil Candesartan Cilexetil is an angiotensin II receptor antagonist (IC50: 0.26 nM). After hydrolysis of candesartan cilexetil to candesartan during gastrointestinal absorption, candesartan selectively competes with angiotensin II for the binding of the angiotensin II receptor subtype 1 (AT1) in vascular
T2531 Eprosartan Mesylate Eprosartan is a competitive and reversible Angiotensin II Receptor Blocker.
T3064 VTP-27999 VTP-27999 is an alkyl amine Renin inhibitor. VTP-27999 has been used in trials studying the basic science of Renal Function.
T3178 BIBS 39 BIBS 39 is a new nonpeptide angiotensin II (AII) receptor antagonist.
T3281 Delapril Hydrochloride Delapril is a prodrug; it is converted into two active metabolites, 5-hydroxy delapril diacid and delapril diacid. These metabolites bind completely to and inhibit angiotensin-converting enzyme (ACE), hence blocking angiotensin I to angiotensin II conversion.
T3461 Exp3174 EXP-3174 is a potent AT1 antagonist (Kis: 0.57 nM, rat; 0.67 nM, human), producing a depressor response and vasodilatation. EXP3174, a metabolite of losartan, is more potent than losartan in blocking the angiotensin II-induced responses in vascular smooth muscle cells.
T6067 PD123319 PD 123319 is a potent, selective AT2 angiotensin II receptor antagonist.
T6133 Remodelin hydrobromide Remodelin HBr salt is a novel potent and selective inhibitor of the acetyl-transferase protein NAT10.
T6219 Azilsartan Medoxomil Azilsartan medoxomil(TAK 491) is an orally administered angiotensin II receptor type 1 antagonist with IC50 of  0.62 nM, which used in the treatment of adults with essential hypertension.
T6340 Enalaprilat Dihydrate Enalaprilat(IC50=1.94 nM) is a potent angiotensin-converting enzyme (ACE) inhibitor.
T6444 Cilazapril Monohydrate Cilazapril Monohydrate is an angiotensin-converting enzyme (ACE) inhibitor used for the treatment of hypertension and congestive heart failure.
T6486 Enalapril Maleate Enalapril Maleate, an angiotensin-converting enzyme (ACE) inhibitor, is utilized in the treatment of hypertension,chronic heart failure , and diabetic nephropathy.
T6542 Imidapril hydrochloride Imidapril HCl is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 2.6 nM, used for the treatment of hypertension.
T6595 Moexipril hydrochloride Moexipril HCl is a potent orally active nonsulfhydrylangiotensin converting enzyme (ACE)inhibitor, used for the treatment of hypertension and congestive heart failure.
T6698 Temocapril hydrochloride Temocapril HCl, the hydrochloride of Temocapril, is a long-acting ACE inhibitor used for the therapy of hypertension.
T6716 Valsartan Valsartan is a tetrazole derivative and angiotensin II type 1 receptor blocker that is used to treat hypertension.
T7040 Angiotensin II human Angiotensin II is mediated by AT1 and AT2 receptors. AT1 and AT2 receptors have seven transmembrane glycoproteins with 30% sequence similarity.Angiotensin I convert Angiotensin II human through removing of two C-terminal residues by the enzyme angiotensin-converting enzyme (ACE).
T4431 EMA401 EMA401, a highly selective AT2R antagonist, inhibition of augmented AngII/AT2R induced p38 and p42/p44 MAPK activation, and hence inhibition of DRG neuron hyperexcitability and sprouting of DRG neurons. EMA401 blocks p38, p42/p44 mitogen-activated protein kinase (MAPK) activation, neurite outgrowth
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