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Porcupine
T2242 Wnt-C59 Wnt-C59(C59) is a highly effective and specific Wnt signaling antagonis with PORCN enzymatic activity.
T2618 LGK-974 LGK-974 is an effective and selective PORCN inhibitor and inhibits Wnt signaling (IC50: 0.4 nM) in TM3 cells. It has been used in trials studying the treatment of Metastatic Colorectal Cancer and Squamous Cell Carcinoma, Head And Neck.
T2683 IWP-L6 IWP-L6 is an extremely effective Porcn inhibitor (EC50: 0.5 nM).
T4438 Porcupine-IN-1 Porcupine-IN-1 is an effective porcupine inhibitor (IC50: 0.5±0.2 nM).
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