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PPAR
T0061 Clofibric acid Clofibric acid is an antilipemic agent that is the biologically active metabolite of CLOFIBRATE.
T0212 Seratrodast Seratrodast (INN), a thromboxane A2 (TXA2) receptor (TP receptor) antagonist, is mainly used in the therapy of asthma. It was the first TP receptor antagonist developed as an anti-asthmatic drug and attained marketing qualification in Japan in 1997.
T0214 Pioglitazone Pioglitazone is an insulin sensitizing agent and thiazolidinedione that is indicated for the treatment of type 2 diabetes. Pioglitazone has been linked to rare instances of acute liver injury.
T0214L Pioglitazone hydrochloride Pioglitazone Hydrochloride is the hydrochloride salt of an orally-active thiazolidinedione with antidiabetic properties and potential antineoplastic activity.
T0334 Rosiglitazone Rosiglitazone is an insulin sensitizing agent and thiazolidinedione that is indicated for the treatment of type 2 diabetes. Rosiglitazone has been linked to rare instances of acute liver injury.
T0448 (S)-(+)-Ibuprofen Dexibuprofen, S(+)-ibuprofen, is a non-steroidal anti-inflammatory drug (NSAID), inhibiting cyclooxygenase (COX).
T0646 5-Aminosalicylic acid Mesalamine is an anti-inflammatory agent, structurally related to the SALICYLATES, which is active in INFLAMMATORY BOWEL DISEASE. It is considered to be the active moiety of SULPHASALAZINE.
T0705 Triflusal Triflusal is a 2-acetoxy-4-trifluoromethylbenzoic acid and it is an aspirin chemically-related molecule but not a derivative.
T0841 Bezafibrate Bezafibrate is an antilipemic agent that lowers CHOLESTEROL and TRIGLYCERIDES. It decreases LOW-DENSITY LIPOPROTEINS and increases HIGH-DENSITY LIPOPROTEINS.
T1088 Repaglinide Repaglinide is a benzoic acid derivative that stimulates insulin secretion from the pancreas and is used in the therapy of type 2 diabetes. Repaglinide has been linked to rare instances of clinically apparent acute liver injury.
T1149 Fenofibrate Fenofibrate is a peroxisome proliferator receptor alpha agonist. Fenofibrate is a synthetic phenoxy-isobutyric acid derivate and prodrug with antihyperlipidemic activity.
T1238 Daidzein Daidzein is an isoflavone extract from soy, which is an inactive analog of the tyrosine kinase inhibitor genistein. It has antioxidant and phytoestrogenic properties.
T1264 Ciprofibrate Ciprofibrate is a fibrate derivative with antilipidemic activity.
T1298 Clofibrate Clofibrate is an aryloxyisobutyric acid derivate with antihyperlipidemic activity.
T1402 Fenofibric acid Fenofibric Acid is the active form of fenofibrate, a synthetic phenoxy-isobutyric acid derivate with antihyperlipidemic activity.
T1415 Gemfibrozil Gemfibrozil interacts with peroxisome proliferator-activated receptors (PPARalpha) resulting in PPARalpha-mediated stimulation of fatty acid oxidation and an increase in lipoprotein lipase (LPL) synthesis. Gemfibrozil is a fibric acid derivative with hypolipidemic effects. This enhances triglyceride
T1603 Glipizide Glipizide is a short-acting, second-generation sulfonylurea with hypoglycemic activity.
T1622 Rosiglitazone maleate Rosiglitazone Maleate is the maleate salt of rosiglitazone, an orally-active thiazolidinedione with antidiabetic properties and potential antineoplastic activity.
T1674 Nateglinide Nateglinide is an oral hypoglycemic agent and amino acid derivative that stimulates insulin secretion from the pancreas and is used in the therapy of type 2 diabetes. Nateglinide has been linked to rare instances of clinically apparent acute liver injury.
T1807 JW55 JW 55 is an effective and selective β-catenin signaling pathway inhibitor, works by inhibition of the PARP domain of tankyrase 1 and tankyrase 2 (TNKS1/2).
T1878 XAV-939 XAV-939 shows the selective inhibition against Wnt/β-catenin-mediated transcription by tankyrase1/2 inhibition (IC50: 11/4 nM in cell-free assays), regulates axin levels and does not affect TGF-β, NF-κB or CRE.
T1941 GSK3787 GSK3787 is a specific and irreversible PPARδ inhibitor(pIC50= 6.6).
T2068 LB-100 LB-100 is a water soluble protein phosphatase 2A (PP2A) inhibitor. Phase 1.
T2260 GW9662 GW9662 is a specific PPARγ antagonist (IC50: 3.3 nM, in a cell-free assay), with 100 to 1000-fold functional selectivity for PPARγ than PPARα/δ in cells.
T2269 Wy-14643 Pirinixic Acid is a synthetic thiacetic acid derivative used in biomedical research, carcinogenic Pirinixic acid is a peroxisome proliferator that activates specific peroxisome proliferator-activated receptors (PPAR).
T2396 Ramatroban Ramatroban (BAY u3405) is a thromboxane A(2) (TxA(2)) antagonist marketed for allergic rhinitis. It has been used in trials studying the treatment of Asthma.
T2413 FH535 FH535, a Wnt/β-catenin signaling and PPAR inhibitor, exhibits anti-tumor activities.
T2674 GSK0660 GSK0660 is an antagonist and inverse agonist of PPARβ/δ.
T2985 Gypenoside XLIX Extracted from whole herb of Gynostemsma pentaphyllum(Thunb.)Mak.;Store the product in sealed, cool and dry condition.
T3000 Magnolol Magnolol is a dual agonist of RXRα( EC50=10.4 µM) and PPARγ(EC50=17.7 µM). It blocks TNF-α-induced NF-KB activation.
T3062 WIKI4 WIKI4 is a potent inhibitor of Wnt/β-catenin signaling and tankyrase 2 (TNKS2).
T3090 Abietic Acid Abietic Acid is the primary component of resin acid isolated from rosin.
T3170 Troglitazone Troglitazone is a PPARγ agonist with anti-inflammatory and anti-tumor activity.
T3261 NVP-TNKS656 NVP-TNKS656 is a highly potent, selective, and orally active TNKS2 inhibitor.
T3709 XMD8-87 XMD8-87 is a TNK2 inhibitor with activity in the inhibition of TNK2 phosphorylation. XMD8-87 and XMD16-5 potently inhibit phosphorylation of TNK2 truncation mutations found in solid tumor types.
T3710 XMD16-5 XMD16-5 is a TNK2 inhibitor. TNK2 genomic amplification has been associated with late-stage or metastatic lung and prostate Ys. Overexpression of TNK2 promoted metastasis in a mouse model of breast Y. TNK2 signaling is disrupted in breast, prostate and gastrointestinal tumors.
T3917 (20R)-Protopanaxatriol Protopanaxatriol, a major ginseng constituent, is a novel PPARγ antagonist.
T6151 GW501516 GW501516 is a effective and highly specifc PPARβ/δ agonist (EC50: 1 nM), with 1000-fold selectivity over hPPARα/γ.
T6524 GW0742 GW0742 (GW610742) is an effective and specific PPARδ agonist (EC50: 1nM/1.1μM/2 μM, for human PPARδ/α/γ).
T6646 Rosiglitazone hydrochloride Rosiglitazone HCl is a blood glucose-lowering drugs, stimulating insulin secretion by binding to the PPAR receptors in fat cells.
T6689 T0070907 T0070907(IC50=1 nM) ,an effective and specific PPARγ inhibitor, with the >800-fold selectivity over PPARα and PPARδ.
T6768 AZ6102 AZ6102 is a potent TNKS1/2 inhibitor that has 100-fold selectivity against other PARP family enzymes and shows IC50 of 5 nM for Wnt pathway inhibition in DLD-1 cells.
T6926 Palmitoylethanolamide Palmitoylethanolamide(PEA) ,an endogenous fatty acid amide, activates PPAR-α selectively in vitro (EC50=3.1±0.4 μM).
T4353 SR-18292 SR-18292 is a PPAR gamma coactivator-1α (PGC-1α) inhibitor, which increases PGC-1α acetylation, suppresses gluconeogenic gene expression and reduces glucose production in hepatocytes.
T4408 Elafibranor Elafibranor is an agonist of the peroxisome proliferator-activated receptor-α (PPAR-α) and peroxisome proliferator-activated receptor-δ (PPAR-δ) with EC50 values of 45 and 175 nM, respectively.
T4449 LB-100 LB-100 is a water-soluble protein phosphatase 2A (PP2A) inhibitor (IC50: 0.85/3.87 μM, in BxPc-3/Panc-1 cells).
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