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PKM
T0745 Disodium monofluorophosphate Sodium Monofluorophosphate is a competitive inhibitor of pyruvate kinase and alkaline phosphatase, which also irreversibly inhibits phosphorylase phosphatase.
T4170 PKM2 inhibitor PKM2 inhibitor(Compound 3K) displays PKM2 inhibitory activity with the IC50 value of 2.95 μM. The IC50 value for PKM1 is 4-5-fold higher than that for PKM2.
T4223 Mitapivat Mitapivat, also known as PKM2 activator 1020 is a PKM2 activator (pyruvate kinase activator) for the treatment of pyruvate kinase deficiency.
T6744 5,5-Dimethyloxazolidine-2,4-dione Dimethadione is an anticonvulsant that is the active metabolite of trimethadione.
T6816 DASA-58 DASA-58 is a specific and potent Pyruvate kinase M2 (PKM2) activator.
T1125 (+)-Shikonin Shikonin is an TMEM16A chloride channel inhibitor (IC50: 6.5 μM). Shikonin is also a selective PKM2 inhibitor and can also suppress activation of the NF-κB pathway and inhibit TNF-α.
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