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PARP
T2105 Veliparib dihydrochloride Veliparib (ABT-888) is a potent inhibitor of PARP1 and PARP2 with Ki of 5.2 nM and 2.9 nM in cell-free assays, respectively. It is inactive to SIRT2.
T2124 PJ34 hydrochloride PJ34 hydrochloride is a potent specific inhibitor of PARPl/2.
T2484 AZD2461 AZD2461 is a novel PARP inhibitor.
T2591 Veliparib (ABT-888) Veliparib is a poly(ADP-ribose) polymerase (PARP) -1 and -2 inhibitor with chemosensitizing and antitumor activities.
T3015 Olaparib Olaparib is a small molecule inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) with potential chemosensitizing, radiosensitizing, and antineoplastic activities.
T3231 Niraparib MK-4827(Niraparib) is a selective inhibitor of PARP1/PARP2 with IC50 of 3.8 nM/2.1 nM; with great activity in cancer cells with mutant BRCA-1 and BRCA-2; >330-fold selective against PARP3, V-PARP and Tank1.
T3375 Verbascoside Verbascoside is a protein kinase C inhibitor with antimicrobial, anti-inflammatory activities.
T3649 BGP-15 BGP-15 is a PARP inhibitor with protecting effect after ischemia-reperfusion injury.
T6127 Rucaparib (AG-014699,PF-01367338) Rucaparib, an inhibitor of PARP, is with Ki of 1.4 nM for PARP1. It also exhibits binding affinity to eight other PARP domains.
T6181 UPF 1069 UPF 1069 is a specific PARP2 inhibitor ( IC50: 0.3 μM). It is ~27-fold selective against PARP1.
T6197 PJ34 PJ34 HCl is the hydrochloride salt of PJ34, which is a PARP inhibitor with EC50 of 20 nM and is equally potent to PARP1/2.
T6224 Iniparib (BSI-201) Iniparib (BSI-201) ,a PARP1 inhibitor, exhibits potency in triple-negative breast Y (TNBC).
T6253 Talazoparib (BMN 673) Talazoparib(IC50=0.58 nM), a new-type PARP inhibitor, effectively inhibits PARP-2, and is very sensitive to PTEN mutation. Talazoparibbut does not inhibit PARG.
T6329 INO-1001 INO-1001 is an effective inhibitor of PARP (IC50<50 nM in CHO cells) and a mediator of oxidant-induced myocyte dysfunction during reperfusion.
T6339 AG-14361 AG14361 is an effective inhibitor of PARP1 (Ki<5 nM).
T6366 A-966492 A-96649 is a new-type and effective inhibitor. The Ki of A-966492 for PARP1 and PARP2 is 1 nM and 1.5 nM, respectively.
T6578 ME0328 ME0328 is a potent and selective PARP inhibitor with IC50 of 0.89 μM for PARP3, about 7-fold selectivity over PARP1.
T6780 Benzamide Benzamide, an inhibitor of poly(ADP-ribose) polymerase, is a derivative of benzoic acid.
T6842 G007-LK G007-LK is a selective inhibitor of TNKS1 and TNKS2, with IC50s of 46 nM and 25 nM, respectively.
T6892 MK-4827(Niraparib) tosylate MK-4827(Niraparib) tosylate (with IC50 of 3.8 nM/2.1 nM) is a selective PARP1/PARP2 inhibitor.
T6912 NU1025 NU1025 is a potent PARP inhibitor with IC50 of 400 nM.
T6942 Picolinamide Picolinamide is found to be a strong inhibitor of poly (ADP-ribose) synthetase of nuclei from rat pancreatic islet cells.
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