||Veliparib (ABT-888) is a potent inhibitor of PARP1 and PARP2 with Ki of 5.2 nM and 2.9 nM in cell-free assays, respectively. It is inactive to SIRT2.
||PJ34 hydrochloride is a potent specific inhibitor of PARPl/2.
||AZD2461 is a novel PARP inhibitor.
||Veliparib is a poly(ADP-ribose) polymerase (PARP) -1 and -2 inhibitor with chemosensitizing and antitumor activities.
||Olaparib is a small molecule inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) with potential chemosensitizing, radiosensitizing, and antineoplastic activities.
||MK-4827(Niraparib) is a selective inhibitor of PARP1/PARP2 with IC50 of 3.8 nM/2.1 nM; with great activity in cancer cells with mutant BRCA-1 and BRCA-2; >330-fold selective against PARP3, V-PARP and Tank1.
||Verbascoside is a protein kinase C inhibitor with antimicrobial, anti-inflammatory activities.
||BGP-15 is a PARP inhibitor with protecting effect after ischemia-reperfusion injury.
||Rucaparib, an inhibitor of PARP, is with Ki of 1.4 nM for PARP1. It also exhibits binding affinity to eight other PARP domains.
||UPF 1069 is a specific PARP2 inhibitor ( IC50: 0.3 μM). It is ~27-fold selective against PARP1.
||PJ34 HCl is the hydrochloride salt of PJ34, which is a PARP inhibitor with EC50 of 20 nM and is equally potent to PARP1/2.
||Iniparib (BSI-201) ，a PARP1 inhibitor， exhibits potency in triple-negative breast Y (TNBC).
||Talazoparib (BMN 673)
||Talazoparib(IC50=0.58 nM), a new-type PARP inhibitor, effectively inhibits PARP-2, and is very sensitive to PTEN mutation. Talazoparibbut does not inhibit PARG.
||INO-1001 is an effective inhibitor of PARP (IC50<50 nM in CHO cells) and a mediator of oxidant-induced myocyte dysfunction during reperfusion.
||AG14361 is an effective inhibitor of PARP1 (Ki<5 nM).
||A-96649 is a new-type and effective inhibitor. The Ki of A-966492 for PARP1 and PARP2 is 1 nM and 1.5 nM, respectively.
||ME0328 is a potent and selective PARP inhibitor with IC50 of 0.89 μM for PARP3, about 7-fold selectivity over PARP1.
||Benzamide, an inhibitor of poly(ADP-ribose) polymerase, is a derivative of benzoic acid.
||G007-LK is a selective inhibitor of TNKS1 and TNKS2, with IC50s of 46 nM and 25 nM, respectively.
||MK-4827(Niraparib) tosylate (with IC50 of 3.8 nM/2.1 nM) is a selective PARP1/PARP2 inhibitor.
||NU1025 is a potent PARP inhibitor with IC50 of 400 nM.
||Picolinamide is found to be a strong inhibitor of poly (ADP-ribose) synthetase of nuclei from rat pancreatic islet cells.