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OX Receptor
T1913 MK-3697 MK-3697, an isonicotinamide small molecule, acts as a potent and selective Orexin 2 receptor antagonist (Ki: 0.95 nM).
T2613 Almorexant Almorexant is a potent and competitive dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist with Ki values of 1.3 and 0.17 nM for OX1 and OX2, respectively.
T2710 TCS 1102 TCS 1102 is an effective, dual orexin receptor antagonist (Ki: 0.2/3 nM for OX2/1 receptors).
T3177 Orexin 2 Receptor Agonist Orexin 2 Receptor Agonist is an effective (EC50: 23 nM) and OX2R-selective (OX1R/OX2R EC50 ratio: 70) agonist.
T3347 PF-3274167 PF-3274167 is a potent and selective, high-affinity nonpeptide oxytocin receptor antagonist.
T3722 MK-1064(Urokinase inhibitor 1) MK-1064 is a selective orexin 2 receptor antagonist (2-SORA).
T6140 SB-334867 SB-334867 is a selective orexin-1 (OX1) receptor antagonist.
T6155 Almorexant hydrochloride Almorexant HCl (ACT078573) is a potent and competitive dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist with Ki values of 1.3 and 0.17 nM for OX1 and OX2, respectively.
T6658 SB408124 SB408124 is a non-peptide antagonist for OX1 receptor with Ki of 57 nM and 27 nM in both whole cell and membrane, respectively, exhibits 50-fold selectivity over OX2 receptor.
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