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Nrf2

Nrf2

Nuclear factor erythroid 2-related factor 2 (NRF2), also known as nuclear factor erythroid-derived 2-like 2, is a transcription factor that in humans is encoded by the NFE2L2 gene. NRF2 is a basic leucine zipper (bZIP) protein that regulates the expression of antioxidant proteins that protect against oxidative damage triggered by injury and inflammation. Several drugs that stimulate the NFE2L2 pathway are being studied for treatment of diseases that are caused by oxidative stress.
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Cat. No. Product Name CAS No. Purity Chemical Structure
TN1058 Pelargonidin chloride
氯化天竺葵素
134-04-3
Pelargonidin chloride 是一种氧化氮自由基的清除剂,具有抗氧化作用。
T11251 Ezetimibe ketone
化合物 T11251
191330-56-0 98%
Ezetimibe, a compound known as a Niemann-Pick C1-like1 (NPC1L1) inhibitor and a potent Nrf2 activator, effectively inhibits cholesterol absorption. Additionally,...
TN4038 Eupatolide
泽兰内酯
6750-25-0 98%
Eupatolide 是从 Inula japonica 的花中分离出来的,具有抗炎活性。 Eupatolide 可用于研究乳腺癌细胞对 TRAIL 的耐药性。
TN5278 Zederone
化合物 TN5278
7727-79-9 98%
Zederone has anti-bacterial activity,it inhibits gram-positive bacteria activity. Zederone induces hepatotoxicity implicated the induction of Cyps, which leads t...
TN1548 6"-O-Malonyldaidzin
6''-O-丙二酰基大豆苷
124590-31-4 98%
6"-O-Malonyldaidzin (Daidzin 6''-O-malonate) 是一种丙二酰化异黄酮,存在于大豆种子中。它可能具有保护眼睛的作用。
TP2109 TAT 14
NRF2激活剂多肽
1362661-34-4 98%
TAT-14 是 由14 个氨基酸组成的多肽,是 Nrf2激活因子,表现出抗炎活性。它通过靶向 Nrf2 上 Keap1 的结合位点而非 Nrf2 mRNA 表达来提高 Nrf2 蛋白水平。
T15474 Hesperin
化合物 T15474
4430-35-7 98%
Hesperin is a bioactive ingredient present in Japanese horseradish (wasabi). It has been shown to be an activator of Nrf2.
TN4064 Flavoglaucin
化合物 TN4064
523-73-9 98%
Flavoglaucin exhibits significant inhibitory effects on PTP1B, the IC50 value of 13.4, micrometer; it also shows good binding affinity for human opioid or cannab...
TMA0237 Carlinoside
化合物 TMA0237
59952-97-5 98%
Carlinoside could be a worthy choice to intervene hyperbilirubinemia due to liver dysfunction. Carlinoside upregulates Nrf2 gene expression, increases its nuclea...
TN4160 Goniothalamin
化合物Goniothalamin
17303-67-2 98%
Goniothalamin 在各种癌细胞系中诱导细胞凋亡并具有胃保护活性。
T9112 (-)-Perillaldehyde
紫苏醛
18031-40-8 98%
L-Perillaldehyde 是紫苏草精油的主要成分,吸入后经由嗅觉神经功能表现出抗抑郁功能。
TN2336 Rehmapicrogenin
地黄苦苷元
135447-39-1 98%
Rehmapicrogenin 调节 Nrf2/ARE 信号通路。Nrf2/ARE 信号通路是氧化应激的重要途径。
TN4420 Latifolin
化合物 TN4420
10154-42-4 98%
Latifolin is a strong DPPH-scavenger, it attenuates inflammatory responses by inhibiting NF-κB activation via Nrf2-mediated heme oxygenase-1 expression. Latifol...
T16352 NSC23925
化合物 T16352
858474-14-3 98%
NSC23925 is a selective and effective inhibitor of P-glycoprotein (Pgp).
TN1670 Ganodermanondiol
灵芝酮二醇
107900-76-5 98%
Ganodermanondiol exhibits potent cytoprotective effects on t-BHP-induced hepatotoxicity in human liver-derived HepG2 cells, presumably through Nrf2-mediated anti...
TN1151 Procyanidol B4
原花青素B4
29106-51-2 98%
Procyanidin B4 reveals significant antioxidant activity
TN3726 Cudraflavone B
化合物 TN3726
19275-49-1 98%
Cudraflavone B has anti-proliferative activity, mouse brain monoamine oxidase (MAO) inhibitory effects, apoptotic actions in human gastric carcinoma cells and mo...
TN1989 Niga-ichigoside F1
苦莓苷F1
95262-48-9 98%
Niga-ichigoside F1(NI) has anti-inflammatory, gastroprotective ,antinociceptive, and cytotoxic effects.
TN3806 Dehydroglyasperin C
化合物 TN3806
199331-35-6 98%
Dehydroglyasperin C is a potent NAD(P)H:oxidoquinone reductase (NQO1) and phase 2 enzyme inducer. Dehydroglyasperin C possesses potent antioxidant, cancer chemop...
TN6711 Toralactone
决明内酯
41743-74-2 98%
Toralactone 是一种分离自决明子中的天然产物,通过 Nrf2 依赖性抗氧化机制介导肝脏保护作用。
Pelargonidin chloride
TN1058
Pelargonidin chloride 是一种氧化氮自由基的清除剂,具有抗氧化作用。
Ezetimibe ketone
T11251
Ezetimibe, a compound known as a Niemann-Pick C1-like1 (NPC1L1) inhibitor and a potent Nrf2 activator, effectively inhibits cholesterol absorption. Additionally,...
Eupatolide
TN4038
Eupatolide 是从 Inula japonica 的花中分离出来的,具有抗炎活性。 Eupatolide 可用于研究乳腺癌细胞对 TRAIL 的耐药性。
Zederone
TN5278
Zederone has anti-bacterial activity,it inhibits gram-positive bacteria activity. Zederone induces hepatotoxicity implicated the induction of Cyps, which leads t...
6"-O-Malonyldaidzin
TN1548
6"-O-Malonyldaidzin (Daidzin 6''-O-malonate) 是一种丙二酰化异黄酮,存在于大豆种子中。它可能具有保护眼睛的作用。
TAT 14
TP2109
TAT-14 是 由14 个氨基酸组成的多肽,是 Nrf2激活因子,表现出抗炎活性。它通过靶向 Nrf2 上 Keap1 的结合位点而非 Nrf2 mRNA 表达来提高 Nrf2 蛋白水平。
Hesperin
T15474
Hesperin is a bioactive ingredient present in Japanese horseradish (wasabi). It has been shown to be an activator of Nrf2.
Flavoglaucin
TN4064
Flavoglaucin exhibits significant inhibitory effects on PTP1B, the IC50 value of 13.4, micrometer; it also shows good binding affinity for human opioid or cannab...
Carlinoside
TMA0237
Carlinoside could be a worthy choice to intervene hyperbilirubinemia due to liver dysfunction. Carlinoside upregulates Nrf2 gene expression, increases its nuclea...
Goniothalamin
TN4160
Goniothalamin 在各种癌细胞系中诱导细胞凋亡并具有胃保护活性。
(-)-Perillaldehyde
T9112
L-Perillaldehyde 是紫苏草精油的主要成分,吸入后经由嗅觉神经功能表现出抗抑郁功能。
Rehmapicrogenin
TN2336
Rehmapicrogenin 调节 Nrf2/ARE 信号通路。Nrf2/ARE 信号通路是氧化应激的重要途径。
Latifolin
TN4420
Latifolin is a strong DPPH-scavenger, it attenuates inflammatory responses by inhibiting NF-κB activation via Nrf2-mediated heme oxygenase-1 expression. Latifol...
NSC23925
T16352
NSC23925 is a selective and effective inhibitor of P-glycoprotein (Pgp).
Ganodermanondiol
TN1670
Ganodermanondiol exhibits potent cytoprotective effects on t-BHP-induced hepatotoxicity in human liver-derived HepG2 cells, presumably through Nrf2-mediated anti...
Procyanidol B4
TN1151
Procyanidin B4 reveals significant antioxidant activity
Cudraflavone B
TN3726
Cudraflavone B has anti-proliferative activity, mouse brain monoamine oxidase (MAO) inhibitory effects, apoptotic actions in human gastric carcinoma cells and mo...
Niga-ichigoside F1
TN1989
Niga-ichigoside F1(NI) has anti-inflammatory, gastroprotective ,antinociceptive, and cytotoxic effects.
Dehydroglyasperin C
TN3806
Dehydroglyasperin C is a potent NAD(P)H:oxidoquinone reductase (NQO1) and phase 2 enzyme inducer. Dehydroglyasperin C possesses potent antioxidant, cancer chemop...
toralactone
TN6711
Toralactone 是一种分离自决明子中的天然产物,通过 Nrf2 依赖性抗氧化机制介导肝脏保护作用。
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