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LRRK2
T1770 GNE-9605 GNE-9605 is a highly effective, specifical, and brain-penetrant LRRK2 inhibitor (IC50: 19 nM).
T1945 GNE-7915 GNE-7915 is a highly potent, selective and brain-penetrable leucine-rich repeat kinase 2 (LRRK2) inhibitor.
T2022 CZC-54252 CZC-54252 is a potent inhibitor of LRRK2.
T2050 PF-06447475 PF-06447475 is a highly effective, specific, brain penetrant LRRK2 inhibitor with IC0 of 3/11 nM for wild type LRRK2 and G2019S LRRK2 respectively.
T2240 GSK2578215A GSK2578215A is a potent and selective LRRK2 kinase inhibitor.
T2246 LRRK2-IN-1 LRRK2-IN-1 is an effective and selective LRRK2 inhibitor.
T3053 CZC-25146 CZC-25146 is an effective, specific and metabolically stable LRRK2 inhibitor with IC50 of 4.76/6.87 nM for wild-type LRRK2(Leucine-rich repeat kinase-2) and G2019S LRRK2, respectively.
T6031 GNE-0877 GNE-0877 is a highly effective and specific leucine-rich repeat kinase 2 (LRRK2) inhibitor (Ki: 0.7 nM).
T6057 URMC-099 URMC-099 is an orally bioavailable, brain penetrant MLK inhibitor (IC50: 19/42/14/150 nM, for MLK1/MLK2/MLK3/DLK), and also inhibits LRRK2 activity (IC50: 11 nM).
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