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IL Receptor
T0117 Suplatast tosilate Suplatast Tosilate is a novel capsular anti-asthmatic drug. It ( IC50 above 100 μM) inhibits both IgE production, IL-4 and IL-5 synthesis.
T0122 Bengenin Bergenin is a polyphenol, which is an effective antinarcotic agent with antioxidant action.
T0694 Pranlukast Pranlukast is a cysteinyl leukotriene receptor-1 antagonist. It antagonizes or reduces bronchospasm caused, principally in asthmatics, by an allergic reaction to accidentally or inadvertently encountered allergens.
T0947 Dexamethasone acetate Dexamethasone Acetate is the acetate salt form of Dexamethasone, a synthetic adrenal corticosteroid with potent anti-inflammatory properties. In addition to binding to specific nuclear steroid receptors, dexamethasone also interferes with NF-kB activation and apoptotic pathways. This agent lacks the
T1076 Dexamethasone Dexamethasone is a synthetic adrenal corticosteroid with potent anti-inflammatory properties.
T1246 Bornyl acetate Bornyl acetate has an anti-inflammatory effect. It is the primary volatile ingredient in some Chinese traditional herbs and numerous conifer oils.
T1273 Diacerein Diacerein is a prodrug which is metabolized to rhein. It is currently approved in France for the treatment of osteoarthritis although the use of diacerein is restricted due to the side effects including sevre diarrhea [L780]. Diacerein is under investigation for the treatment of Insulin Resistance,
T1347 2-Benzothiazolamine 2-Aminobenzothiazole is an organic compound.
T1639 Amlexanox Amlexanox is an anti-aphthous ulcer drug. Amlexanox inhibits the synthesis and release of inflammatory mediators, including leukotrienes and histamine, from mast cells, neutrophils, and mononuclear cells. Amlexanox also acts as a leukotriene D4 antagonist and a phosphodiesterase inhibitor. Amlexanox
T1813 VGX-127 VGX-1027(GIT27) is an isoxazole compound with various immunomodulatory properties.
T2018 Apilimod Apilimod inhibits the production of IL-12 and IL-23 and reduces dendritic cell infiltration in psoriasis.
T3133 YM-90709 YM-90709 is a new-type antagonist inhibiting the binding of interleukin-5 to the interleukin-5 receptor.
T3280 Disodium clodronate tetrahydrate Disodium clodronate tetrahydrate inhibits bone resorption and soft tissue calcification.
T3332 Isosteviol Isosteviol, a common natural sweetener, belongs to tetracyclic diterpene glycosides. The pharmacology researches have suggested that stevioside and its hydrolysis products, steviol, isosteviol and steviolbioside, have many biological activities, such as reducing blood glucose, lowering blood pressur
T3416 Aucubin Aucubin is an iridoid glycoside with anti-inflammatory, anti-microbial, anti-algesic as well as anti-tumor activities.
T3533 Apilimod mesylate Apilimod mesylate is a potent IL-12/IL-23 inhibitor.
T3614 Isoprinosine Isoprinosine has a number of immunomodulatory effects, including inducing T-lymphocyte differentiation, augmenting macrophage and NK cell functions, and stimulating IL-2 production. Through these effects and others, isoprinosine shows antiviral activity and has applications against subacute scleros
T3830 20R-Ginsenoside Rg2 20R-Ginsenoside Rg2 is a compound with anti-oxidant and anti-apoptosis.
T3910 Anemoside B4 Anemoside B4 inhibits the secretion of IL-10.
T6465 Dexamethasone Sodium Phosphate Dexamethasone, an interleukin receptor modulator, has anti-inflammatory and immunosuppressant effects. It belongs to a potent glucocorticoid class of steroid synthetic drugs.
T6761 AS101 AS101, a potent in vitro and in vivo immunomodulator, is a novel inhibitor of IL-1beta converting enzyme.
T4140 IRAK4-IN-1 IRAK4-IN-1 is an interleukin-1 receptor associated kinase 4 (IRAK4) inhibitor with an IC50 of 7 nM.
T4279 Esonarimod Esonarimod is an antirheumatic drug.
T4450 GIBH-130 GIBH-130 markedly inhibits the IL-1β secretion by activated microglia (IC50: 3.4 nM). GIBH-130 is an effective inhibitor of neuroinflammation.
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