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IDO
T6543 Indoximod (NLG-8189) Indoximod is a methylated tryptophan with immune checkpoint inhibitory activity. Indoximod inhibits the enzyme indoleamine 2,3-dioxygenase (IDO), which degrades the essential amino acid tryptophan, and may increase or maintain tryptophan levels important to T cell function. Tryptophan depletion is a
T3548 Epacadostat Epacadostat is an oral-available inhibitor of indoleamine 2,3-dioxygenase (IDO1), increasing the proliferation and activation of various immune cells and reducing tumor-associated regulatory T cells.
T1806 NLG919 NLG919 is a potent IDO (indoleamine-(2,3)-dioxygenase) pathway inhibitor.
T4142 DO-IN-2 IDO-IN-2 is an IDO inhibitor extracted from patent WO/2015031295 A1, compound example 1.
T4307 PF-06840003 PF-06840003 is a specific and oral active IDO-1 inhibitor.
T6407 Beta-Lapachone Beta-Lapachone is a specific DNA topoisomerase I inhibitor, and no inhibitory activities against DNA topoisomerase II or ligase.
T2647 INCB024360 analogue IDO-IN-2 is an effective IDO1 inhibitor(IC50=10 nM).
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