||Indoximod is a methylated tryptophan with immune checkpoint inhibitory activity. Indoximod inhibits the enzyme indoleamine 2,3-dioxygenase (IDO), which degrades the essential amino acid tryptophan, and may increase or maintain tryptophan levels important to T cell function. Tryptophan depletion is a
||Epacadostat is an oral-available inhibitor of indoleamine 2,3-dioxygenase (IDO1), increasing the proliferation and activation of various immune cells and reducing tumor-associated regulatory T cells.
||NLG919 is a potent IDO (indoleamine-(2,3)-dioxygenase) pathway inhibitor.
||IDO-IN-2 is an IDO inhibitor extracted from patent WO/2015031295 A1, compound example 1.
||PF-06840003 is a specific and oral active IDO-1 inhibitor.
||Beta-Lapachone is a specific DNA topoisomerase I inhibitor, and no inhibitory activities against DNA topoisomerase II or ligase.
||IDO-IN-2 is an effective IDO1 inhibitor(IC50=10 nM).