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HSP
T1501 Rifabutin Rifabutin inhibits bacterial DNA-dependent RNA polymerase, thereby suppressing the initiation of RNA formation and leading to inhibition of RNA synthesis and transcription. Rifabutin is a semisynthetic ansamycin antibiotic with potent antimycobacterial properties.
T1989 NVP-AUY922 AUY922 (NVP-AUY922) is a new-type synthetic resorcinylic isoxazole amide inhibitor of heat shock protein 90 (HSP90). It has been used in trials studying the treatment and basic science of lymphoma, leukemia, T-cell lymphoma, hepatic Impairment, and follicular lymphoma, among others.
T2114 NVP-BEP800 NVP-BEP800, a synthetic HSP90β inhibitor (IC50: 58 nM), exhibits >70-fold selectivity against Hsp90 family members Trap-1 and Grp94.
T2179 Triptolide Triptolide is a diterpenes trioxide, immunosuppressive agent extracted from the Chinese herb Tripterygium wilfordii.
T2258 VER-50589 VER-50589 is a potent HSP90 inhibitor.
T2268 VER-49009 VER-49009 is an effective HSP90 inhibitor(IC50 =25 nM,Kd=78 nM).
T2286 BIIB-021 BIIB021 is an orally-available, fully synthetic inhibitor of HSP90(Ki=1.7nM,EC50=38nM).
T2309 Ganetespib Ganetespib is a synthetic small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity.
T2444 KNK437 KNK437, a pan-HSP inhibitor, suppresses the synthesis of inducible HSPs(HSP105, HSP72, and HSP40).
T3293 Apoptozole Apoptozole is an inhibitor of the ATPase domain of Hsc70 and Hsp70,and can induce apoptosis.
T3527 TRC 051384 Inducer of heat shock protein Hsp70; reduces stroke-associated neuronal injury and increases survival in a rat model of transient ischemic stroke. Activates heat shock factor-1 and results in elevated chaperone and anti-inflammatory activity. Enhances Hsp72 expression in neurons and glial cells.
T3594 ML346 ML346 is a novel activator of Hsp70.
T6118 HSP990 (NVP-HSP990) NVP-HSP990 (HSP990) is an effective and specific HSP90α/β inhibitor (IC50: 0.6 /0.8 nM).
T6170 Elesclomol (STA-4783) Elesclomol (STA-4783) is an effective oxidative stress inducer that elicits pro-apoptosis of tumor cells.
T6248 XL888 XL888 is an ATP-competitive inhibitor of Hsp90 ( IC50: 24 nM). Heat shock protein 90 (Hsp90) is a chaperone that maintains the functionality of client proteins involved in cell proliferation, cell cycling, and apoptosis. Through this action, specific client proteins are degraded, resulting in cell c
T6284 AT13387 Onalespib is a synthetic, orally bioavailable, small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity. Onalespib selectively binds to Hsp90, thereby inhibiting its chaperone function and promoting the degradation of oncogenic signaling proteins involved in t
T6290 17-AAG 17-AAG (Tanespimycin), an effective HSP90 inhibitor (IC50: 5 nM), has a 100-fold higher binding affinity for HSP90 derived from tumour cells than HSP90 from normal cells.
T6305 SNX-2112 SNX-2112 is an orally active Hsp90 inhibitor, with a Kd of 16 nM.
T6341 PF-04929113 SNX-5422 is a synthetic, novel, small molecule Hsp90 Inhibitor. As an oral formulation that demonstrates strong efficacy and tolerability, SNX-5422 is positioned as a breakthrough therapy with broad applicability across a wide range of cancers.
T6343 Geldanamycin Geldanamycin, an HSP90 inhibitor (Kd: 1.2 μM), specifically disrupts glucocorticoid receptor (GR)/HSP association.
T6442 CH5138303 CH5138303 is an orally available Hsp90 inhibitor with Kd of 0.48 nM.
T6558 KW-2478 KW-2478 is a non-ansamycin HSP90 inhibitor with IC50 of 3.8 nM.
T6609 NMS-E973 NMS-E973 is a potent and selective Hsp90 inhibitor with DC50 of <10 nM for Hsp90 binding, no activiy against a panel of 52 diverse protein kinases.
T6855 HA15 HA15 targets specifically BiP/GRP78/HSPA5. HA15 exhibits anti-cancerous activity on all melanoma cells tested, including cells isolated from patients and cells that developed resistance to BRAF inhibitors.
T6960 PU-H71 PU-H71 is a potent and selective inhibitor of HSP90 with IC50 of 51 nM. Phase 1.
T7010 VER155008 VER-155008 is a potent Hsp70 family inhibitor with IC50 of 0.5 μM, 2.6 μM, and 2.6 μM in cell-free assays for HSP70, HSC70, and GRP78, respectively, >100-fold selectivity over HSP90.
T4125 HSF1A HSF1A is a cell-permeable activator of HSF1 that protects mammalian cells against stress-induced apoptosis.
T4342 PF-04929113 Mesylate PF-04929113 Mesylate, a prodrug of SNX-2112, is an orally available Hsp90 inhibitor (Kd: 41 nM) and also induces Her-2 degradation (IC50: 37?nM).
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