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HIF
T0447 Carvedilol Carvedilol Phosphate is the phosphate salt form of carvedilol, a racemic mixture and adrenergic blocking agent with antihypertensive activity and devoid of intrinsic sympathomimetic activity. The S enantiomer of carvedilol nonselectively binds to and blocks beta-adrenergic receptors, thereby exertin
T1939 DMOG DMOG, an antagonist of the α-ketoglutarate cofactor, is an inhibitor for HIF prolyl hydroxylase.
T2220 2-Methoxyestradiol 2-Methoxyestradiol is an orally bioavailable estradiol metabolite with potential antineoplastic activity. 2-Methoxyestradiol inhibits angiogenesis by reducing endothelial cell proliferation and inducing endothelial cell apoptosis. This agent also inhibits tumor cell growth by binding to tubulin, res
T2488 BAY 87-2243 BAY 87-2243 is a potent and selective inhibitor of hypoxia-inducible factor-1 (HIF-1).
T2515 FG-4592 Roxadustat is an orally bioavailable, hypoxia-inducible factor prolyl hydroxylase inhibitor (HIF-PHI), with potential anti-anemic activity.
T3027 Sodium Aescinate Sodium Aescinate is extracted from Aesculus wilsonii.
T3169 KC7F2 KC7F2 is a potent HIF-1 pathway inhibitor with potential anti-cancer activity.
T3197 Daprodustat Daprodustat (GSK1278863) is a HIF-prolyl hydroxylase inhibitor.
T3404 Cucurbitacin B Cucurbitacin B has profound in vitro and in vivo antiproliferative effects against human pancreatic Y cells. It inhibited AKT signaling activation through up-regulation of PTEN. Cucurbitacin B is an effective inhibitor of HIF-1 and provide new perspectives into the mechanism of its anticancer activi
T3494 LW6 LW6 is a novel HIF-1 inhibitor.
T6804 Chetomin Chetomin is an inhibitor of HIF-1 by weaken transcription of HIF-1,disrupting the binding of HIF-1α and HIF-2α to p300 at low nanomolar concentrations.
T6929 Pantoprazole sodium Pantoprazole Sodium is the sodium salt form of a substituted benzimidazole with proton pump inhibitor activity. Pantoprazole is a lipophilic, weak base that crosses the parietal cell membrane and enters the acidic parietal cell canaliculus where it becomes protonated, producing the active metabolite
T6961 PX-478 2HCl PX-478 2HCl is an orally active, and selective inhibitor of hypoxia-inducible factor-1α (HIF-1α).
T4381 Lificiguat(YC-1) YC-1 is an nitric oxide (NO)-independent activator of soluble guanylyl cyclase(sGC) and an inhibitor of Hypoxia-inducible factor-1alpha (HIF-1alpha).
T4106 MK-8617 MK-8617 is an orally available HIF PHD1?3 pan-inhibitor, inhibiting PHD1/2/3 (IC50: 1.0/1.0/14 nM).
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