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Estrogen/progestogen Receptor
T0035 Dienestrol Dienestrol is a synthetic and nonsteroidal estrogen, which is an estrogen receptor agonist. Estrogens can increase a normal clear discharge from the vagina and make the vulva and urethra healthy.
T0040 Quinestrol Quinestrol  is a synthetic estrogen, applied in hormone replacement therapy, and occasionally to use in cancer and prostate cancer treatment.
T0139 Toremifene Toremifene is a selective estrogen-receptor modulator (SERM).
T0168 Estradiol cypionate Estradiol cypionate, the 17 β-cyclopentylpropinate ester of estradiol, inhibits ET-1 synthesis via estrogen receptor.
T0171 Norethynodrel Norethynodrel is a synthetic progestational hormone with actions and uses similar to those of PROGESTERONE. It has been used in the treatment of functional uterine bleeding and endometriosis. As a contraceptive, it has usually been administered in combination with MESTRANOL.
T0188 Fluticasone propionate Fluticasone propionate, derived from fluticasone used to remedy asthma and allergic rhinitis, is a high affinity, selective GR (glucocorticoid receptor) agonist.
T0301 Ethisterone Ethisterone is a progestogen hormone.
T0345 Estropipate Estropipate is a natural estrogenic substance composed of estrone sulfate and piperazine.
T0384 Estradiol benzoate Estradiol Benzoate is the synthetic benzoate ester of estradiol, a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females.
T0478 Progesterone Progesterone is the major progestational steroid that is secreted primarily by the CORPUS LUTEUM and the PLACENTA. Progesterone acts on the UTERUS, the MAMMARY GLANDS and the BRAIN. It is required in EMBRYO IMPLANTATION; PREGNANCY maintenance, and the development of mammary tissue for MILK productio
T0593 XCT790 XCT790 is a potent, selective and inverse agonist of estrogen-related receptor alpha(ERRα).
T0709 Natamycin Natamycin is a Polyene Antimicrobial.
T0835 Tamoxifen Z-isomer citrate Tamoxifen is an antineoplastic nonsteroidal selective estrogen receptor modulator (SERM).
T0870 Altrenogest Altrenogest(A35957; RU2267), a progestogen, has structural relation with veterinary steroid trenbolone.
T0996 Ethynodiol diacetate Ethynodiol diacetate is a synthetic progestational hormone used alone or in combination with estrogens as an oral contraceptive.
T1009 Estrone Estrone is an aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone, a major mammalian estrogen. It is converted from ANDROSTENEDIONE directly, or from TESTOSTERONE via ESTRADIOL. In humans, it is produced primarily by the cyclic ovaries, PLACENTA, and the ADIPOSE TISSUE of men and postmeno
T1048 Estradiol Estradiol is an Estrogen. The mechanism of action of estradiol is as an Estrogen Receptor Agonist.
T1102 Mifepristone Mifepristone is a Progestin Antagonist. The mechanism of action of mifepristone is as a Progestational Hormone Receptor Antagonist.
T1193 Clomifene citrate Clomifene Citrate is a selective estrogen receptor modulator.
T1216 Diethylstilbestrol Diethylstilbestrol is used in the treatment of menopausal and postmenopausal disorders.
T1261 Farlutin Medroxyprogesterone acetate is a synthetic progestin that is derived from 17-hydroxyprogesterone. It is a long-acting contraceptive that is effective both orally or by intramuscular injection and has also been used to treat breast and endometrial neoplasms.
T1263 Levonorgestrel Levonorgestrel is a Progestin and Progestin-containing Intrauterine Device. The physiologic effect of levonorgestrel is by means of Inhibit Ovum Fertilization.
T1284 Megestrol acetate Megestrol acetate is a progestogen with actions and uses similar to those of the progestogens in general. Megestrol acetate also has anti-androgenic properties. It is given by mouth in the palliative treatment or as an adjunct to other therapy in endometrial carcinoma and in breast cancer. Megestrol
T1377 Methyldienedione Methyldienedione is an anabolic steroid and a precursor to dienolone.
T1424 Ethynyl estradiol Ethinyl estradiol is a semisynthetic alkylated ESTRADIOL with a 17-alpha-ethinyl substitution. It has high estrogenic potency when administered orally, and is often used as the estrogenic component in ORAL CONTRACEPTIVES.
T1429 17-Hydroxyprogesterone Hydroxyprogesterone is a physiological progestin that is produced during glucocorticoid and steroid hormone synthesis and is increased during the third trimester of pregnancy. Hydroxyprogesterone binds to the cytoplasmic progesterone receptors in the reproductive system and subsequently activates pr
T1438 Butoconazole nitrate Butoconazole Nitrate is the nitrate salt form of butoconazole, a synthetic imidazole derivative with fungistatic properties. Butoconazole nitrate interferes with steroid biosynthesis by inhibiting the conversion of lanosterol to ergosterol, thereby changing the fungal cell membrane lipid composition
T1464 Toremifene citrate Toremifene citrate is a selective estrogen receptor modulator (SERM). It is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on the mammary and uterine tissue.
T1480 Danazol Danazol is a synthetic steroid with antigonadotropic and anti-estrogenic activities that acts as an anterior pituitary suppressant by inhibiting the pituitary output of gonadotropins. It possesses some androgenic properties. Danazol has been used in the treatment of endometriosis and some benign bre
T1490 Gestodene Gestodene is a progestogen hormonal contraceptive.
T1514 Norethindrone Norethindrone is a synthetic progestational hormone with actions similar to those of PROGESTERONE but functioning as a more potent inhibitor of ovulation. It has weak estrogenic and androgenic properties. The hormone has been used in treating amenorrhea, functional uterine bleeding, endometriosis, a
T1536 Promestriene Promestriene (INN) is a synthetic estrogen and glucocorticoid used topically in a 1% cream formulation. It is described as a tropic agent and antiseborrheic.
T1541 Drospirenone Drospirenone is a synthetic spironolactone analogue and progestin with progestational and anti-mineralocorticoid activity.
T1549 Raloxifene hydrochloride Raloxifene hydrochloride is a second generation selective estrogen receptor modulator (SERM) used to prevent osteoporosis in postmenopausal women. It has estrogen agonist effects on bone and cholesterol metabolism but behaves as a complete estrogen antagonist on mammary gland and uterine tissue.
T1571 Estriol Estriol is a hydroxylated metabolite of ESTRADIOL or ESTRONE that has a hydroxyl group at C3, 16-alpha, and 17-beta position. Estriol is a major urinary estrogen. During PREGNANCY, a large amount of estriol is produced by the PLACENTA.
T1579 Mestranol Mestranol, a semisynthetic estrogen, is used as an estrogen receptor agonist and must be demethylated to be biologically active.
T1659 Melatonin Melatonin is a biogenic amine that is found in animals and plants. In mammals, melatonin is produced by the PINEAL GLAND. Its secretion increases in darkness and decreases during exposure to light. Melatonin is implicated in the regulation of SLEEP, mood, and REPRODUCTION. Melatonin is also an effec
T1688 5β-Pregnane-3α,20α-diol 5Beta-Pregnane-3Alpha,20alpha-Diol is an inactive metabolite of PROGESTERONE by reduction at C5, C3, and C20 position. Pregnanediol has two hydroxyl groups, at 3-alpha and 20-alpha. It is detectable in URINE after OVULATION and is found in great quantities in the pregnancy urine.
T2146 Fulvestrant Fulvestrant is a steroidal antiestrogen that is used in the treatment of hormone-receptor positive metastatic breast cancer. Fulvestrant therapy can be associated with serum enzyme elevations, but has yet to be linked to instances of clinically apparent acute liver injury in the published literature
T2177 Kaempferol Kaempferol is a natural flavonoid which has been isolated from Delphinium, Witch-hazel, grapefruit, and other plant sources.
T2195 Epiandrosterone Epiandrosterone is a dehydroepiandrosterone metabolite and a precursor of testosterone and estradiol with hypolipidemic and anabolic property.
T2231 17-Beta-Estradiol-3,17-Dipropionate Estradiol dipropionate is a synthetic ester, specifically the 3,17-dipropanoyl ester, of the natural estrogen, estradiol.
T2250 DY131 DY131 is a novel selective agonist of ERRβ and ERRγ.
T2280 Endoxifen Z-isomer Endoxifen (EDX) is a key active metabolite of tamoxifen (TAM) with higher affinity and specificity to estrogen receptors that also inhibits aromatase activity.
T2527 Ulipristal acetate Ulipristal Acetate is an orally bioavailable, acetate salt of ulipristal, a selective progesterone receptor modulator with anti-progesterone activity. Ulipristal binds to the progesterone receptor (PR), thereby inhibiting PR-mediated gene expression, and interfering with progesterone activity in the
T2544 Bazedoxifene acetate Bazedoxifene acetate is a novel selective estrogen receptor modulator (SERM).
T2559 Allylestrenol Allylestrenol is a synthetic steroid with progestational activity.
T2567 Etonogestrel Etonogestrel is a steroidal progestin used as hormonal contraceptives.
T2569 Chlorotrianisene Chlorotrianisene is an orally bioavailable, highly lipophilic, synthetic triphenylethylene (TPE) derivative and selective estrogen receptor modulator (SERM), with predominantly estrogenic but also antiestrogenic activities.
T2577 Dienogest Dienogest is an orally-active, semisynthetic, fourth generation, nonethinylated progestogen with antiproliferative, antiandrogenic, anti-inflammatory and antiangiogenic activities that is used in hormone therapy and as a female contraceptive.
T2597 Norgestrel Norgestrel is a synthetic progestin commonly used alone or in combination with an estrogen for contraception. Norgestrel suppresses the secretion of luteinizing and follicle-stimulating hormones (LH and FSH), thickens cervical mucus, and slows the transit of ova through the fallopian tubes.
T2598 Thymopentin Synthetic pentapeptide corresponding to the amino acids 32-36 of thymopoietin and exhibiting the full biological activity of the natural hormone. THYMOPENTIN is an immunomodulator which has been studied for possible use in the treatment of rheumatoid arthritis, AIDS, and other primary immunodeficien
T2973 Astragaloside IV Astragaloside IV, an active component isolated from Astragalus membranaceus, suppresses the activation of ERK1/2 and JNK, and downregulates matrix metalloproteases (MMP)-2, (MMP)-9 in MDA-MB-231 breast cancer cells. Astragaloside IV is a bioactive saponin first isolated from the dried plant roots of
T3325 Liquiritigenin Liquiritigenin, a flavonoid aglycone from licorice, is a highly selective estrogen receptor β (ERβ) agonist.
T3378 17α-Estradiol Endogenous estrogen receptor ligand (Ki values are 0.2 and 1.2 nM for ERα and ERβ receptors respectively).
T3645 Endoxifen E-isomer hydrochloride Endoxifen, a tamoxifen metabolite, is effective specific Estrogen Response Modifier (SERM).
T3717 β-thujaplicin β-thujaplicin can inhibit ultraviolet B-induced apoptosis in keratinocytes and strongly suggest that the inhibitory mechanism is due to the antioxidant activity of metallothionein induced by the agent. Also, β-Thujaplicin modulates estrogen receptor signaling and inhibits proliferation of human br
T3806 kaempferide Kaempferide triglycoside inhibits the proliferation of native and estrogen receptor beta overexpressing colon cancer cells through a mechanism not mediated by ligand binding dependent estrogen receptor activation.
T3846 Bavachin Bavachin is a phytoestrogen that activates the estrogen receptors ERα and ERβ.
T3958 WAY 200070 WAY-200070 is a specific agonist of estrogen receptor β (ERRβ, IC50: 2.3 nM).
T3975 AZD9496 AZD9496 is an orally available selective estrogen receptor(ERα) antagonist, with potential antineoplastic activity.
T4000 (±)-Equol Equol is a non-steroidal estrogen produced from the metabolism of the isoflavonoid phytoestrogen daidzen by human intestinal microflora. The estrogen receptor (ER) agonist activity of the naturally occurring (S)-enantiomer (EC50 = 85 and 65 nM for human ERα and ERβ, respectively) is similar to t
T6306 LY500307 LY500307 is a potent, selective estrogen receptor β agonist with EC50 of 0.66 nM, 32-fold selectivity against estrogen receptor α. Phase 2.
T6404 Bazedoxifene hydrochloride Bazedoxifene HCl is a novel, non-steroidal, indole-based estrogen receptor modulator (SERM) binding to both ERα and ERβ with IC50 of 23 nM and 89 nM, respectively.
T6491 Equol S-equol is an orally bioavailable, non-steroidal estrogen naturally produced by the metabolism of the isoflavonoid daidzein by human intestinal microflora, with potential chemoprotective and estrogen receptor (ER) modulating activities. S-equol preferentially binds to and activates the beta isoform
T6533 Hexestrol Hexestrol binds to ERα and ERβ with EC50 of 0.07 nM and 0.175 nM, respectively.
T6620 Ospemifene Ospemifene is a new selective non-hormonal estrogen receptor modulator (SERM) that is used for the treatment of moderate to severe dyspareunia, a symptom of vulvar and vaginal atrophy, due to menopause. FDA approved on February 26, 2013.
T6683 STF-62247 STF-62247 is TGN inhibitor with IC50 of 0.625 μM and 16 μM in RCC4 and RCC4/VHL cells,respectively.
T6713 Ulipristal Ulipristal is a selective SPRM for emergency contraception after an unprotected intercourse or contraceptive failure.
T6819 Desogestrel Desogestrel is a synthetic progestational hormone used often as the progestogenic component of combined oral contraceptive agents.
T6827 Endoxifen Z-isomer hydrochloride Endoxifen HCl is the active metabolite of Tamoxifen, which is an effective and selective estrogen receptor antagonist.
T6906 Tamoxifen Tamoxifen is an antagonist of the estrogen receptor in breast tissue.
T4281 (E/Z)-Endoxifen Tamoxifen is an antineoplastic nonsteroidal selective estrogen receptor modulator (SERM).
T4388 PHTPP PHTPP is a selective?ERβ?antagonist.
T4420 (Z)-4-hydroxy Tamoxifen <p>Afimoxifene, a tamoxifen metabolite, is estrogen receptor antagonist (IC50: 3.3 nM). It also increases CRISPR/Cas9-mediated editing frequency.</p>
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