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Dopamine Receptor
T2714 Rotundine Rotundine is extracted from Corydalis yanhusuo W. T. Wang.
T1476 Pramipexole Pramipexole is a selective dopamine receptor agonist used in the therapy of Parkinson disease. Pramipexole therapy is associated with a low rate of transient serum enzyme elevations during treatment but has not been implicated in cases of clinically apparent acute liver injury.
T4274 MELITRACEN HYDROCHLORIDE Melitracen Hydrochloride, an antidepressant, is used as potential dopamine D1/2 receptor antagonist to treat depression.
T0351 Risperidone Risperidone is a selective blocker of dopamine D2 receptors and serotonin 5-HT2 receptors that act as an atypical antipsychotic agent.
T0302 Triflupromazine hydrochloride Triflupromazine hydrochloride, an antipsychotic medication, is Dopamine D1/D2 receptor antagonists.
T3426 Bacoside A Bacoside A is a mixture of chemical compounds. Its major constituents include the saponins bacoside A3, bacopaside II, jujubogenin isomer of bacopasaponin C, and bacopasaponin C. The mixture has been studied in in vitro experiments and animal models for its potential neuroprotectivity.
T0162 Quetiapine Quetiapine is used for the therapy of schizophrenia, and for the treatment of acute manic episodes associated with bipolar I disorder. The mechanism of quetiapine' action is thought by mediated through antagonist activity at serotonin and dopamine receptors. Specifically, the D1 and D2 dopamine, the
T6241 Quetiapine Fumarate Quetiapine Fumarate, an atypical antipsychotic, is used in the treatment of bipolar I mania, schizophrenia, bipolar II depression, bipolar I depression.
T6142 PD128907 hydrochloride PD 128907 HCl is a potent and selective dopamine D3 receptor agonist, with EC50 of 0.64 nM, exhibits 53-fold selectivity over dopamine D2 receptor.
T0074 Chlorprothixene Chlorprothixene is a typical antipsychotic drug of the thioxanthene class,which was the first of the series to be synthesized.
T0031L Ziprasidone hydrochloride Ziprasidone (hydrochloride) is a united 5-HT (serotonin) and dopamine receptor antagonist which shows potent effects of antipsychotic activity.
T1540 Doxepin hydrochloride Doxepin Hydrochloride is a dibenzoxepin tricyclic compound. It displays a range of pharmacological actions including maintaining adrenergic innervation. Its mechanism of action is not fully understood, but it appears to block reuptake of monoaminergic neurotransmitters into presynaptic terminals. It
T4369 SCH 23390 hydrochloride SCH 23390 hydrochloride is an effective dopamine receptor antagonist, and for the D1(Ki=0.2 nM) and D5(Ki=0.3 nM).
T0185 Escitalopram Escitalopram is a furancarbonitrile that is one of the SEROTONIN UPTAKE INHIBITORS used as an antidepressant. The drug is also effective in reducing ethanol uptake in alcoholics and is used in depressed patients who also suffer from tardive dyskinesia in preference to tricyclic antidepressants, whic
T3497 Ocaperidona Ocaperidona (Ocaperidone), a very high affinity dopamine D2 antagonist.
T0365 Thioridazine hydrochloride Thioridazine, an antipsychotic drug, is used in the therapy of psychosis and schizophrenia and shows serotonin antagonism or D4 selectivity.
T1336 Benztropine mesylate Benztropine mesylate is a centrally active muscarinic antagonist that has been used in the symptomatic treatment of PARKINSON DISEASE. Benztropine also inhibits the uptake of dopamine.
T1567 Olanzapine Olanzapine is an atypical antipsychotic that is used currently in the treatment of schizophrenia and bipolar illness.
T1180 Blonanserin Blonanserin is an atypical antipsychotic approved in Japan in January, 2008. Relative to many other antipsychotics, blonanserin has an improved tolerability profile, lacking side effects such as extrapyramidal symptoms, excessive sedation, or hypotension.
T1539 Iloperidone Iloperidone is an atypical antipsychotic agent that is used for treatment of schizophrenia.
T1471 Duloxetine hydrochloride Duloxetine hydrochloride is a thiophene derivative and selective neurotransmitter uptake inhibitor for SEROTONIN and NORADRENALINE (SNRI). It is an ANTIDEPRESSIVE AGENT and ANXIOLYTIC and is also used for the treatment of pain in patients with DIABETES MELLITUS and FIBROMYALGIA.
T0031 Ziprasidone hydrochloride monohydrate Ziprasidone(CP88059) is a united 5-HT (serotonin) and dopamine receptor antagonist which shows potent effects of the antipsychotic activity.
T0076 Paliperidone Paliperidone(Invega) is used as an atypical antipsychotic. It applies to the acute and maintenance treatment of schizophrenia. Chemically, paliperidone is the primary active metabolite of the older atypical antipsychotic risperidone.
T3337 Ddr1-In-1 DDR1-IN-1 is an effective and specific DDR1 receptor tyrosine kinase inhibitor (IC50: 105 nM), about 3-fold selectivity over DDR2.
T0068 Fluphenazine dihydrochloride Fluphenazine dihydrochloride is an inhibitor of phenothiazine-class D1DR and D2DR; In studies, Fluphenazine can be used to probe the effects and metabolic process of this commonly used dopamine antagonist.
T0031L2 Ziprasidone Ziprasidone is an a typical antipsychotic used in the treatment of schizophrenia and bipolar disorder. Use of ziprasidone has not been consistently associated with serum enzyme elevations and has yet to be linked to instances of clinically apparent acute liver injury.
T1233 Oxolinic acid Oxolinic acid is a synthetic antimicrobial related to NALIDIXIC ACID and used in URINARY TRACT INFECTIONS.
T1517 Benserazide hydrochloride Benserazide Hydrochloride is a peripherally-acting L-amino acid decarboxylase (AAAD) or DOPA decarboxylase inhibitor.
T3187 Fluoroclebopride Fluoroclebopride is a dopamine (DA) D2 receptor ligand.
T0716 Molindone hydrochloride Molindone hydrochloride is an indole derivative effective in schizophrenia and other psychoses by blocking the effects of dopamine in the brain.
T1201 Sulpiride Sulpiride is a dopamine D2-receptor antagonist, used therapeutically as an antidepressant, antipsychotic, and as a digestive aid.
T6951 Pramipexole 2HCl Monohydrate Pramipexole Dihydrochloride is the hydrochloride salt of pramipexole, a benzothiazole derivative. As a nonergot dopamine agonist, pramipexole binds to D2 and D3 dopamine receptors in the striatum and substantia nigra of the brain.
T2546 Pimozide Pimozide is a diphenylbutylpiperidine derivative and a dopamine antagonist with the antipsychotic property. Pimozide selectively inhibits type 2 dopaminergic receptors in the central nervous system (CNS), thereby decreasing dopamine neurotransmission and reducing the occurrence of the motor and voca
T3046 BMY 7378 dihydrochloride BMY-7378, α1D-adrenergic receptor antagonist, is a weak partial agonist/antagonist of 5-HT1A receptor.
T0783 Mianserin hydrochloride Mianserin hydrochloride is a tetracyclic compound with antidepressant effects. it apparently blocks alpha-adrenergic, histamine H1, and some types of serotonin receptors. It may cause drowsiness and hematological problems.
T4081 MPTP-hydrochloride MPTP-hydrochloride is a precusor of MPP+ which is toxic to dopaminergic neurons and causes Parkinsonism.
T1211 Levosulpiride Levosulpiride is the (S)-enantiomer of sulpiride, which is a D2 receptor antagonist, an atypical antipsychotic drug of the benzamide class.
T0785 Dexchlorpheniramine Maleate Dexchlorpheniramine (trade name Polaramine) is an antihistamine with anticholinergic properties used to treat allergic conditions such as hay fever or urticaria. It is the pharmacologically active dextrorotatory isomer of chlorpheniramine.
T0338 Minaprine dihydrochloride Minaprine is a reversible inhibitor of MAO-A, used in the treatment of various depressive states.
T1105 Penfluridol Penfluridol is a highly potent antipsychotic.
T3431 Pardoprunox hydrochloride Pardoprunox hydrochloride is a novel partial dopamine D2 and D3 receptor agonist and serotonin 5-HT1A receptor agonist, D2 (pKi = 8.1) and D3 receptor (pKi = 8.6) partial agonist and 5-HT1A receptor (pKi = 8.5) full agonist.
T1769 Pardoprunox Pardoprunox is a partial dopamine D2 agonist and noradrenergic agonist with serotonin 5-HT1A agonist properties. Pardoprunox has been used in trials studying the treatment of Early Stage Parkinson's Disease and Advanced Stage Parkinson's Disease.
T1412 Loxapine succinate salt Loxapine succinate, a D2DR and D4DR inhibitor, is utilized in schizophrenia.
T1150 Bupropion hydrochloride Bupropion Hydrochloride does not inhibit monoamine oxidase and, compared to classical tricyclic antidepressants, is a weak blocker of the neuronal uptake of serotonin and norepinephrine. Buproprion also weakly inhibits the neuronal reuptake of dopamine. This agent is the hydrochloride salt of an ami
T3086 Mesoridazine Besylate Mesoridazine (Serentil) is a piperidine neuroleptic drug belonging to the class of drugs called phenothiazines, used in the treatment of schizophrenia. It is a metabolite of thioridazine.
T2132 Buspirone hydrochloride Buspirone is a 5HT(1A) receptor agonist, used to treat generalized anxiety disorder (GAD).
T0322 Fipexide Fipexide (Attentil, Vigilor), a psychoactive drug of the piperazine chemical class, was developed in Italy in 1983. It was served as a nootropic drug in France and Italy, mainly for the therapy of senile dementia, but is no longer in common use because of the occurrence of rare drug side-effects inc
T3278 Piribedil Piribedil is a dopamine D2 agonist, used in the treatment of Parkinson's disease.
T1735 Lurasidone hydrochloride Lurasidone hydrochloride is a thiazole derivative and atypical antipsychotic agent that functions as a dopamine D2 receptor antagonist; serotonin 5-HT2 receptor antagonist, serotonin 5-HT7 receptor antagonist, an antagonist of the adrenergic α2A and α2C receptors, as well as a partial serotonin 5-
T3085 Piperacetazine Piperacetazine, an antipsychotic prodrug, is used forschizophrenia.
T1175 Bromopride Bromopride is a dopamine antagonist with prokinetic properties closely related to metoclopramide, and is widely used as an antiemetic. It is not available in the United States or the United Kingdom.
T2092 Amitifadine hydrochloride Amitifadine hydrochloride is a triple reuptake inhibitor (TRI) or serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI).
T1222 Trifluoperazine dihydrochloride Trifluoperazine Dihydrochloride is a potent dopamine D2 receptor inhibitor used as an antipsychotic and an antiemetic.
T3369 Nuciferine Nuciferine is an alkaloid found within the plants Nymphaea caerulea and Nelumbo nucifera. It has a profile of action associated with dopamine receptor blockade.
T1292 Tiapride hydrochloride Tiapride is a selective blocker of D2/3 dopamine receptors in the brain. It is used in the therapy of various psychiatric and neurological disorders containing dyskinesia, negative symptoms of psychosis, alcohol withdrawal syndrome, and aggression and agitation in the elderly.
T2564 Flupenthixol dihydrochloride Flupenthixol dihydrochloride is a dopamine receptor antagonist.
T1045 Trimipramine maleate Trimipramine maleate appears to inhibit serotonin transport and norepinephrine uptake by nerve terminals. This increases available norepinephrine or serotonin and prolongs its action. Trimipramine Maleate is the maleate salt form of trimipramine, a tricyclic secondary amine of the dibenzazepine clas
T2874 Tetrahydroberberine Tetrahydroberberine is an isoquinoline alkaloid isolated from corydalis tuber, has a micromolar affinity for dopamine D(2) receptors.
T0025 Haloperidol Haloperidol is a highly potent neuroleptic by relieving nervous through the depression of nerve function. In addition, haloperidol has shown about 50-fold efficacy than chlorpromazine, another antipsychotic drug. Haloperidol has some potencies in the treatment of delusions and hallucinations. Its ef
T0766 Promazine hydrochloride Promazine hydrochloride is a phenothiazine with actions similar to CHLORPROMAZINE but with less antipsychotic activity. It is primarily used in short-term treatment of disturbed behavior and as an antiemetic.
T4117 Zuclopenthixol Zuclopenthixol is a thioxanthene with therapeutic actions similar to the phenothiazine antipsychotics. It is an antagonist at D1 and D2 dopamine receptors.
T0990 Droperidol Droperidol is a Dopamine-2 Receptor Antagonist. The mechanism of action of droperidol is as a Dopamine D2 Antagonist.
T0505 L-(-)-α-Methyldopa Methyldopa, an alpha-adrenergic agonist (selective for α2-adrenergic receptors) psychoactive medicine, is served as an antihypertensive or sympatholytic.
T0287 Hexamethonium Bromide Hexamethonium Bromide, a specific antagonist of neuronal-type nicotinic AChR in ganglia, is poorly absorbed from the gastrointestinal tract and does not cross the blood-brain barrier.
T0082 Domperidone Domperidone(Motilium) is a dopamine blocker and an antidopaminergic reagent. It blocks the action of. It has strong affinities for the D2 and D3 dopamine receptors, which are found in the chemoreceptor trigger zone, located just outside the blood brain barrier, which - among others - regulates nause
T0455 Clozapine Clozapine is a tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also display
T1090L Prochlorperazine Prochlorperazine is an antipsychotic phenothiazine derivative.
T1090 Perphenazine Perphenazine is a phenothiazine derivative and a dopamine antagonist with antiemetic and antipsychotic properties.
T0719 Tetrabenazine Tetrabenazine is a drug formerly used as an antipsychotic and treatment of various movement disorders. Tetrabenazine blocks neurotransmitter uptake into adrenergic storage vesicles and has been used as a high affinity label for the vesicle transport system.
T2574 Alizapride hydrochloride Alizapride hydrochloride is a dopamine receptor antagonist used for the treatment of nausea and vomiting.
T0848 L-DOPA Levodopa is an amino acid precursor of dopamine with antiparkinsonian properties. Levodopa is a prodrug that is converted to dopamine by DOPA decarboxylase and can cross the blood-brain barrier. When in the brain, levodopa is decarboxylated to dopamine and stimulates the dopaminergic re
T0445 Promethazine Tafluprost(AFP-168) is an analogue of anti-glaucoma prostaglandin (PG) .
T1322 Bendazol Bendazol is always used as the drug for hypertension and cerebral Angiospasm.
T1644 Dopamine hydrochloride Dopamine is a naturally occurring catecholamine formed by decarboxylation of dihydroxyphenylalanine and a precursor of norepinephrine and epinephrine. Dopamine binds to alpha-1- and beta-1- adrenergic receptors.
T6988 SKF38393 HCl SKF38393 HCl is a selective dopamine D1/D5 receptor agonist.
T0074L Chlorprothixene hydrochloride Chlorprothixene brings strong blocking effects by blocking the 5-HT2 D1, D2, D3, histamine H1, muscarinic and alpha1 adrenergic receptors. Chlorprothixene is a typical antipsychotic drug of the thioxanthene (tricyclic) class.
T2226 Pergolide mesylate salt PERGOLIDE MESYLATE is a long-acting dopamine agonist which has been used to treat PARKINSON DISEASE and HYPERPROLACTINEMIA but withdrawn from some markets due to potential for HEART VALVE DISEASES.
T1406 Amantadine hydrochloride Amantadine hydrochloride is an antiviral that is used in the prophylactic or symptomatic treatment of influenza A and Parkinson disease.
T6835 Fenoldopam mesylate Fenoldopam is a selective dopamine-1 receptor (DA1) agonist with natriuretic/diuretic properties. It lowers blood pressure through arteriolar vasodilation.
T1871 GBR 12935 dihydrochloride GBR 12935 can induce the increase of the extracellular levels of dopamine to basal levels.
T3526 Dasotraline hydrochloride Dasotraline hydrochloride (SEP-225289 hydrochloride) is a triple reuptake inhibitor  that inhibits dopamine, norepinephrine, and serotonin transporters with IC50 values of 4, 6, and 11 nM, respectively.
T1384 Chlorpromazine hydrochloride Chlorpromazine hydrochloride is the prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking DOPAMINE RECEPTORS. Chlorpromazine has several other actions and therape
T0811 Amisulpride Amisulpride (trade name Solian) is an antipsychotic drug sold by Sanofi-Aventis. It is not approved for use in the United States, but is approved for use in Europe and Australia for the treatment of psychoses and schizophrenia. Additionally, it is approved in Italy for the treatment of dysthymia (
T1069 Metoclopramide hydrochloride Metoclopramide hydrochloride is a selective dopamine D2 receptor antagonist, used as an antiemetic.
T0333 Aniracetam Aniracetam(Ro 13-5057), a nootropic and neuroprotective drug, selectively modulates the AMPA receptor and nAChR.
T2190 Methiothepin mesylate Methiothepin mesylate is a potent and non-selective 5-HT2 receptor antagonist,used as an antipsychotic.
T0280 Spiperone Spiperone is a spiro butyrophenone analog similar to HALOPERIDOL and other related compounds. It has been recommended in the treatment of SCHIZOPHRENIA.
T0469 Octopamine hydrochloride Octopamine (OA) is a biogenic monoamine structurally associated with noradrenaline. It can serve as a neurohormone, a neurotransmitter, and a neuromodulator in invertebrates.
T0869 Atomoxetine hydrochloride Atomoxetine Hydrochloride is the hydrochloride salt of atomoxetine, a phenoxy-3-propylamine derivative and selective non-stimulant, norepinephrine reuptake inhibitor with cognitive-enhancing activity. Although its precise mechanism of action is unknown, atomoxetine appears to selectively inhib
T0385 Prochlorperazine Maleate Prochlorperazine maleate is a phenothiazine antipsychotic used principally in the treatment of NAUSEA; VOMITING; and VERTIGO. It is more likely than CHLORPROMAZINE to cause EXTRAPYRAMIDAL DISORDERS.
T0137 Mirtazapine Mirtazapine is a tetracyclic antidepressant with a somewhat unique mechanism of action. Mirtazapine therapy can be associated with transient asymptomatic elevations in serum aminotransferase levels and has been linked to rare instances of clinically apparent acute liver injury.
T1327 Nortriptyline hydrochloride Nortriptyline hydrochloride is a metabolite of AMITRIPTYLINE that is also used as an antidepressive agent. Nortriptyline is used in major depression, dysthymia, and atypical depressions.
T2306 Brexpiprazole Brexpiprazole is a partial agonist of human 5-hydroxytryptamine (5-HT) 5-HT1A and dopamine D2 receptors.
T2592 Ropinirole hydrochloride Ropinirole a selective dopamine D2 receptors agonist (Ki: 29 nM). Ropinirole Hydrochloride is the hydrochloride salt form of ropinirole, a non-ergot dopamine agonist with antiparkinsonian property.
T0776 Phenothiazine Phenothiazine is a class of agents exhibiting antiemetic, antipsychotic, antihistaminic, and anticholinergic activities. Phenothiazines antagonize the dopamine D2-receptor in the chemoreceptor trigger zone (CTZ) of the brain, potentially preventing chemotherapy-induced emesis.
T4007 Eticlopride hydrochloride Eticlopride is a selective dopamine antagonist that acts on D2 dopamine receptor. It is primarily used in pharmacological research.
T0136 Citicoline The mechanism of action of imiquimod is as an Interferon Inducer. The physiologic effect of imiquimod is by means of Increased cytokine activity, and increased cytokine production.
T6647 Rotigotine Rotigotine is a non-ergot dopamine receptor agonist used in the therapy of Parkinson disease and restless leg syndrome. Administered as a once-daily transdermal patch, Rotigotine has not been associated with serum enzyme elevations during treatment or with episodes of clinically apparent liver injur
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