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DNA Methyltransferase
T0018 Procainamide hydrochloride Procainamide Hydrochloride is the hydrochloride salt form of procainamide, an amide derivative exhibiting class 1A antiarrhythmic property and analog of procaine. Procainamide hydrochloride reversibly binds to and blocks activated (open) voltage-gated sodium channels, thereby blocks the influx of so
T1339 5-Azacytidine Azacitidine, a pyrimidine nucleoside analogue of cytidine, blocks DNA methylation with antineoplastic activity.
T1508 Decitabine Decitabine incorporates into DNA and inhibits DNA methyltransferase, resulting in hypomethylation of DNA and intra-S-phase arrest of DNA replication. Decitabine is a cytidine antimetabolite analog with potential antineoplastic activity.
T1904 SGI-1027 SGI-1027 is an effective and selective inhibitor of DNA methyltransferase (DNMT). The IC50 of SGI-1027 against DNMT1, DNMT3A, and DNMT3B are 6, 8, 7.5 μM, respectively.
T2038 RG108 RG108 is an DNA methyltransferase inhibitor(IC50=115 nM).
T2169 Zebularine Zebularine is a DNA methylation inhibitor. Acts as a transition state analog inhibitor of cytidine deaminase by binding to the active size as covalent hydrates. It also inhibits cytidine deaminase (Ki: 2 μM, in a cell-free assay).
T3089 6-Thioguanine Thioguanine is an antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia.
T3458 EED226 EED226 is a potent, selective, and orally bioavailable embryonic ectoderm development (EED) inhibitor with an IC50 of 22 nM.
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