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DNA Alkylation
T0377 Clofazimine Clofazimine is a phenazine dye with anti-mycobacterial and anti-inflammatory activities. Clofazimine has a slow bactericidal effect on Mycobacterium leprae and is active against various other Mycobacteria.
T0707 Cyclophosphamide monohydrate Cyclophosphamide is an alkylating agent used in the treatment of several forms of cancer including leukemias, lymphomas and breast cancer.
T0923 Busulfan Busulfan is a synthetic derivative of dimethane-sulfonate with antineoplastic and cytotoxic properties. Although its mechanism of action is not fully understood, busulfan appears to act through the alkylation of DNA. Following systemic absorption of busulfan, carbonium ions are formed, resulting in
T0942 Quinacrine dihydrochloride Quinacrine Hydrochloride is the dihydrochloride salt of the 9-aminoacridine derivative quinacrine with potential antineoplastic and antiparasitic activities.
T0951 Hydroxychloroquine sulfate Hydroxychloroquine sulfate inhibits plasmodial heme polymerase. It is a chemotherapeutic agent that acts against erythrocytic forms of malarial parasites. Hydroxychloroquine appears to concentrate in food vacuoles of affected protozoa.
T0975 Chlorambucil Chlorambucil is an orally-active antineoplastic aromatic nitrogen mustard. Chlorambucil alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis.
T1241 Altretamine Altretamine is an alkylating agent with antineoplastic activity.
T1250 Thio-TEPA Thiotepa is a polyfunctional, organophosphorus alkylating agent with antineoplastic activity.
T1343L Crystal Violet Crystal violet is a triarylmethane dye that is a mixture of violet rosanilinis, with antibacterial, antifungal, and anthelmintic properties.
T1507 Streptozocin Streptozotocin is an antibiotic that is produced by Stretomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals.
T1548 Methoxsalen Methoxsalen is a Photoactivated Radical Generator and Psoralen. The mechanism of action of methoxsalen is as a Photoabsorption. The physiologic effect of methoxsalen is by means of Photosensitizing Activity.
T1601 Lomustine Lomustine is an alkylating agent of value against both hematologic malignancies and solid tumors.
T2495 Lomeguatrib Lomeguatrib, a modified guanine base, inhibits the activity of DNA repair protein O(6)-alkylguanine-DNA alkyltransferase (MGMT) .
T3091 Carmustine Carmustine is a cell-cycle phase nonspecific alkylating antineoplastic agent.
T3707 GNE-3511 GNE-3511 is a potent and selective dual leucine zipper kinase inhibitors.
T4024 Norharmane Norharmane is a natural β-carboline first isolated from plants of the Zygophyllaceae family.
T4187 Gemcitabine monophosphate Gemcitabine monophosphate disodium salt is a monophosphate derivative of Gemcitabine.
T4350 Palifosfamide Palifosfamide lysine (ZIO-201) is a stable form of palifosfamide. Palifosfamide lysine has broad activity in sarcoma lines in vitro. The IC50 ranges from 2.25 to 6.75 μM for most cell lines except OS222 (IC50=31.5 μM).
T6057 URMC-099 URMC-099 is an orally bioavailable, brain penetrant MLK inhibitor (IC50: 19/42/14/150 nM, for MLK1/MLK2/MLK3/DLK), and also inhibits LRRK2 activity (IC50: 11 nM).
T4368 Miriplatin Miriplatin (SM-11355) is a platinum complex used in TACE that has promise for the therapy of hepatocellular carcinoma (HCC).
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