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Caspase
T0282 Q-VD-OPH Q-VD-OPha is a pan-caspase inhibitor with potent antiapoptotic properties.
T1564 Cisplatin Cisplatin, an inorganic platinum complex, is able to suppress DNA synthesis by conforming DNA adducts in cancer cells.
T1772 Apoptosis Activator 2 Apoptosis Activator 2 is a potent apoptosis activator, induceing caspase-3 activation, PARP cleavage, and DNA fragmentation .
T2503 PAC-1 PAC-1 has been used in trials studying the treatment of Lymphoma, Melanoma, Solid Tumors, Breast Cancer, and Thoracic Cancers, among others.
T3519 Formosanin C Polyphyllin B is a compound isolated from Rhizoma Paridis, showed pro-apoptosis and immunoregulation with antitumor activity in cultured cells and animal systems.
T3600 LICOCHALCONE-A Licochalcone A is a flavonoid isolated from the famous Chinese medicinal herb Glycyrrhiza uralensis Fisch with obvious anti-cancer effects.
T3907 Senegenin Senegenin is a natural product from Polygala tenuifolia used in Chinese medicine with antioxidative and anti-inflammatory activity.
T3914 Saikosaponin C Saikosaponin C efficiently inhibited LPS-induced apoptotic cell death via inhibition of caspase-3 activation and caspase-3-mediated-FAK degradation.
T6005 Z-DEVD-FMK Z-DEVD-FMK is a selective, irreversible Caspase-3 inhibitor, and also exhibits effective inhibition activity on caspase-6, caspase-7, caspase-8, and caspase-10.
T6013 Z-VAD-FMK Z-VAD(OMe)-FMK is a cell-permeable, irreversible pan-caspase inhibitor.
T6090 Belnacasan (VX-765) VX-765 is an orally active IL-converting enzyme/caspase-1 inhibitor.
T6191 Tasisulam Tasisulam is an apoptosis inducer and an antitumor agent via the intrinsic pathway.
T6826 Emricasan Emricasan is an effective and irreversible pan-caspase inhibitor.
T7016 VR23 VR23 is a potent proteasome inhibitor. Data shows IC50 =1 nM for trypsin-like proteasomes, IC50=50-100 nM for chymotrypsin-like proteasomes, and IC50=3 μM for caspase-like proteasomes.
T7019 Z-IETD-FMK Z-IETD-FMK is a selective caspase 8 inhibitor, which has cell permeable.
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