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T0004 Salicylamide Salicylamide is an over-the-counter drug with analgesic and antipyretic properties, which has similar medicinal properties to aspirin. In the over-the-counter pain remedies, Salicylamide is used in combination with both aspirin and caffeine.
T0005 Aspirin Acetylsalicylic acid is a potent and selective inhibitor of COX with various pharmacological activities, such as anti-inflammation and pain relief. Acetylsalicylic acid is a histone deacetylase inhibitors to up-regulate cell cycle arrest protein p21, which can suppresses ovarian Y cells harboring CO
T0050 4-Aminoantipyrine 4-Aminoantipyrine is a reagent for glucose determination in the presence of peroxidase and phenol.
T0055 Glafenine Glafenine, a non-narcotic analgesic agent, is a non-steroidal anti-inflammatory drug (NSAID), and widely used for the therapy of pains of various origins.
T0057 Famprofazone Famprofazone (Gewodin, Gewolen) has analgesic, anti-inflammatory, and antipyretic effects.It is a non-steroidal anti-inflammatory agent (NSAID) of the pyrazolone series.
T0058 Anovigam Anovigam is white or almost-white crystalline powder. Almost odorless. Tasteless. It is widely used as an antipyretic anodyne.
T0065 Acetaminophen Analgesic antipyretic derivative of acetanilide. Acetaminophen has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
T0184 Fenoprofen calcium salt hydrate Fenoprofen calcium is a propionic acid derivative that is used as a non-steroidal anti-inflammatory agent.
T0196 Diclofenac Diclofenac is a nonsteroidal benzeneacetic acid derivative with anti-inflammatory activity. Diclofenac binds and chelates both isoforms of cyclooxygenase (COX-1 and-2), thereby blocking the conversion of arachidonic acid to pro-inflammatory-proprostaglandins.
T0212 Seratrodast Seratrodast (INN), a thromboxane A2 (TXA2) receptor (TP receptor) antagonist, is mainly used in the therapy of asthma. It was the first TP receptor antagonist developed as an anti-asthmatic drug and attained marketing qualification in Japan in 1997.
T0219 Valdecoxib Valdecoxib is a prescription drug used in the treatment of osteoarthritis, rheumatoid arthritis, and painful menstruation and menstrual symptoms. It is classified as a nonsteroidal anti-inflammatory drug, or NSAID, and should not be taken by anyone allergic to these types of medications.
T0260 Meclofenamate Sodium Meclofenamate Sodium, a non-steroidal anti-inflammatory agent, has properties of antipyretic and antigranulation activities. It also inhibits prostaglandin biosynthesis.
T0285 Isoxicam Isoxicam is a non-steroidal anti-inflammatory drug that is not marketed in the United States.
T0291 Flurbiprofen Flurbiprofen is an anti-inflammatory analgesic and antipyretic of the phenylalkynoic acid series. It has been shown to reduce bone resorption in periodontal disease by inhibiting CARBONIC ANHYDRASE.
T0319 Suxibuzone Suxibuzone is a drug used for joint and muscular pain. It is a prodrug of the non steroidal anti inflammatory drug phenylbutazone, and is commonly used in horses.
T0321 Indoprofen Indoprofen is a non-steroidal anti-inflammatory drug.
T0335 Sodium salicylate Sodium salicylate, a metabolite of acetylsalicylic acid, can inhibit NF-kB and reduce oxidative stress.
T0424 Bismuth Subsalicylate Bismuth subsalicylate is the active ingredient in the popular medication Pepto-Bismol that is used to treat nausea, heartburn, indigestion, upset stomach, diarrhea, and other temporary discomforts of the stomach and gastrointestinal tract.
T0435 Sulfinpyrazone Sulfinpyrazone is a uricosuric drug that is used to reduce the serum urate levels in gout therapy. It lacks anti-inflammatory, analgesic, and diuretic properties.
T0436 6-Acetamidohexanoic acid 6-Acetamidohexanoic acid is a kind of amino acids deriviate.
T0441 Pasiniazid Pasiniazid is an anti-TB and anti-leprosy drug.
T0443 Salicoside Salicin, a phenol β-glycoside produced from willow bark, shows anti-inflammatory functions.
T0448 (S)-(+)-Ibuprofen Dexibuprofen, S(+)-ibuprofen, is a non-steroidal anti-inflammatory drug (NSAID), inhibiting cyclooxygenase (COX).
T0451 Minoxidil Minoxidil is an orally administered vasodilator with hair growth stimulatory and antihypertensive effects.
T0456 Cinchophen Cinchophen, an analgesic drug,is utilized in treating gout.
T0458 Indomethacin Indomethacin is a Nonsteroidal Anti-inflammatory Drug. The mechanism of action of indomethacin is as a Cyclooxygenase Inhibitor.
T0459 Sulindac Sulindac is a sulfinylindene derivative prodrug with potential antineoplastic activity. Converted in vivo to an active metabolite, sulindac, a nonsteroidal anti-inflammatory drug (NSAID), blocks cyclic guanosine monophosphate-phosphodiesterase (cGMP-PDE), an enzyme that inhibits the normal apoptosis
T0463 Loxoprofen Loxoprofen is an anti-inflammatory non-steroidal medicine.
T0466 Celecoxib Celecoxib is a Nonsteroidal Anti-inflammatory Drug. The mechanism of action of celecoxib is as a Cyclooxygenase Inhibitor.
T0477 Zileuton Zileuton is a synthetic derivative of hydroxyurea with antiasthmatic properties. The leukotriene inhibitor zileuton blocks 5-lipoxygenase, which catalyzes the formation of leukotrienes from arachidonic acid; causes bronchodilation; decreases bronchial mucous secretion and edema; and may prevent or d
T0484 Deracoxib Deracoxib is a non-steroidal, non-narcotic anti-inflammatory drug. It is also a selective cyclooxygenase-2 inhibitor, and IC50 Value: 70 to 150 uM(inhibition of 3 osteosarcoma cell lines).
T0498 Sasapyrine Salsalate is an orally available salicylate and non-steroidal anti-inflammatory drug (NSAID), with anti-inflammatory, analgesic and antipyretic activities.
T0646 5-Aminosalicylic acid Mesalamine is an anti-inflammatory agent, structurally related to the SALICYLATES, which is active in INFLAMMATORY BOWEL DISEASE. It is considered to be the active moiety of SULPHASALAZINE.
T0649 Salicylic acid Salicylic acid, a natural compound extracted from Willow bark, is an anti-inflammatory inhibitor of activity cyclooxygenase.
T0693 Niflumic acid Niflumic acid is a Ca2+-activated Cl- channel blocker and an analgesic and anti-inflammatory agent used in the therapy of rheumatoid arthritis.
T0708 Oxaprozin Oxaprozin is a Nonsteroidal Anti-inflammatory Drug. The mechanism of action of oxaprozin is as a Cyclooxygenase Inhibitor. The chemical classification of oxaprozin is Nonsteroidal Anti-inflammatory Compounds.
T0726 Benzydamine hydrochloride Benzydamine hydrochloride, a locally-acting nonsteroidal anti-inflammatory drug, has local anaesthetic and analgesic properties.
T0734 Antipyrine Antipyrine, an antipyretic and analgesic, has been given as ear drops and by mouth. Antipyrine is frequently used to test the effects of other diseases or drugs on drug-metabolizing enzymes in the liver.
T0758 Piroxicam Piroxicam is a non-specific COX inhibitor.
T0778 Phenacetin Phenacetin is a phenylacetamide that was formerly used in ANALGESICS but nephropathy and METHEMOGLOBINEMIA led to its withdrawal from the market.
T0784 Tolfenamic Acid Tolfenamic acid (TA) is one of the class of non-steroidal anti-inflammatory drugs (NSAIDs). It is used to treat the symptoms of migraine.
T0798 Triamcinolone Triamcinolone is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. Upon cell entry, triamcinolone binds to and activates the glucocorticoid receptor, which leads to translocation of the ligand-receptor complex to the nucleus and induces expression of glucocorticoi
T0822 Catechin Catechin((+)-Catechin; D-Catechin) is a flavan-3-ol, a type of natural phenol and antioxidant.
T0825 Ebselen Ebselen is a organoselenium compound with anti-inflammatory, anti-oxidant and cytoprotective activity. Ebselen acts as a glutathione peroxidase mimetic and is thereby able to prevent cellular damage induced by reactive oxygen species (ROS). In addition, this agent inhibits the activity of a var
T0826 Meloxicam Meloxicam is a Nonsteroidal Anti-inflammatory Drug. The mechanism of action of meloxicam is as a Cyclooxygenase Inhibitor. The chemical classification of meloxicam is Nonsteroidal Anti-inflammatory Compounds.
T0839 Ketoprofen Ketoprofen is a propionic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic and antipyretic effects. Ketoprofen inhibits the activity of the enzymes cyclo-oxygenase I and II, resulting in a decreased formation of precursors of prostaglandins and thr
T0839L (S)-(+)-Ketoprofen Dexketoprofen works by blocking the action of a substance in the body called cyclo-oxygenase. It belongs to a class of medicines called non-steroidal anti-inflammatory drugs (NSAIDs). Cyclo-oxygenase is involved in the production of chemicals in the body called prostaglandins. Prostaglandins are pr
T0855 (R)-Naproxen (R)-Naproxen, an anti-inflammatory agent, has antipyretic and analgesic properties. Both the acid and its sodium salt are used in the therapy of acute gout or dysmenorrhea, musculoskeletal disorders, rheumatoid arthritis and other rheumatic.
T0858 Flufenamic acid Flufenamic acid is an anthranilic acid derivative with analgesic, anti-inflammatory, and antipyretic properties. It is used in musculoskeletal and joint disorders and administered by mouth and topically.
T0867 Bufexamac Bufexamac is a COX inhibitor for IFN-α release with anti-inflammatory, analgesic, and antipyretic action.
T0888 4-Biphenylacetic acid Felbinac (INN, or biphenylylacetic acid), a topical medicine, is an active metabolite of fenbufen. It is belonging to the family of medicines known as non-steroidal anti-inflammatory drugs (NSAIDs) of the arylpropionic acid class, which is used to treat muscle arthritis and inflammation.
T0890 Mefenamic acid Mefenamic acid is a non-steroidal anti-inflammatory agent with analgesic, anti-inflammatory, and antipyretic properties. It is an inhibitor of cyclooxygenase.
T0907 Sulfasalazine Sulfasalazine is a synthetic salicylic acid derivative with affinity for connective tissues containing elastin and formulated as a prodrug
T0980 Nifenazone Nifenazone is a pyrazole drug, used in the in the treatment of rheumatic disorders.
T1002 Etodolac Etodolac inhibits the activity of cyclooxygenase I and II, thereby preventing the formation of prostaglandin which is involved in the induction of pain, fever, and inflammation. Etodolac is a pyranocarboxylic acid and non-steroidal anti-inflammatory drug (NSAID) with antipyretic and analgesic activi
T1133 Nimesulide Nimesulide is a relatively COX-2 selective inhibitor with analgesic and antipyretic properties.
T1185 Rofecoxib Rofecoxib binds to and inhibits the enzyme cyclooxygenase-2 (COX-2), resulting in an inhibition of the conversion of arachidonic acid to prostaglandins. Rofecoxib is a synthetic, nonsteroidal derivative of phenyl-furanone with anti-inflammatory, antipyretic and analgesic properties and potential ant
T1191 Analgin Analgin is a drug that has analgesic, anti-inflammatory, and antipyretic properties. It is the sodium sulfonate of AMINOPYRINE.
T1191L Dipyron Analgin is a drug that has analgesic, anti-inflammatory, and antipyretic properties. It is the sodium sulfonate of AMINOPYRINE.
T1209 Flunixin meglumin Flunixin Meglumin is an effective inhibitor of the enzyme cyclooxygenase with anti-inflammatory and antipyretic activity.
T1212 Ketorolac tromethamine salt Ketorolac non-selective inhibits the enzymes cyclooxygenase 1 (COX-1) and COX-2with anti-inflammatory, analgesic, and antipyretic activities.
T1258 Nabumetone Nabumetone(BRL14777) is a non-steroidal anti-inflammatory drug and its active metabolite 6MNA inhibits the enzymes cyclo-oxygenase I and II.
T1280 Nepafenac Nepafenac is a Nonsteroidal Anti-inflammatory Drug. The mechanism of action of nepafenac is as a Cyclooxygenase Inhibitor. The chemical classification of nepafenac is Nonsteroidal Anti-inflammatory Compounds.
T1296 Aminopar Aminosalicylic Acid is an analog of para-aminobenzoic acid (PABA) with antitubercular activity.
T1325 Carprofen Carprofen is a propionic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic activities.
T1376 2-Amino-5-methyl-3-thiophenecarbonitrile 2-Amino-5-methyl-3-thiophenecarbonitrile is an organic compund with molecular fomula C6H6N2S.
T1394 Ibuprofen Ibuprofen is a propionic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic effects. Ibuprofen inhibits the activity of cyclo-oxygenase I and II, resulting in a decreased formation of precursors of prostaglandins and thromboxanes.
T1401 Meclofenoxate hydrochloride Meclofenoxate hydrochloride is an ester of DIMETHYLAMINOETHANOL and para-chlorophenoxyacetic acid. It has been shown to improve memory and general cognition, and mentally stimulating effect.
T1420 Diethylcarbamazine citrate Diethylcarbamazine citrate is an anthelmintic used primarily as the citrate in the treatment of filariasis, particular infestations with Wucheria bancrofti or Loa loa. It is an inhibitor of arachidonic acid metabolism in filarial microfilaria.
T1421 Aceclofenac Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) with marked anti-inflammatory and analgesic properties.
T1423 Hydroxytoluic acid Hydroxytoluic Acid is a long-acting salicylate derivative with antilipidemic properties. Hydroxytoluic acid has been shown to lower plasma free fatty acid and cholesterol levels.
T1427 Fosfosal Fosfosal, used as the anti-inflammatory agent, has the anti-bacterial effect.
T1432 Phenylbutazone Phenylbutazone is a butyl-diphenyl-pyrazolidinedione that has anti-inflammatory, antipyretic, and analgesic activities. It has been used in ankylosing spondylitis, rheumatoid arthritis, and reactive arthritis.
T1467 Acemetacin Acemetacin is a carboxymethyl ester of indometacin. It is a potent non-steroidal anti-inflammatory drug, derived from the indol-3-acetic acid, whose activity is thought to be mainly through its active metabolite indomethacin. In clinical trials, acemetacin exhibits a better gastric tolerability comp
T1468 Lornoxicam Lornoxicam (chlortenoxicam) is a new nonsteroidal anti-inflammatory drug (NSAID) of the oxicam class with analgesic, anti-inflammatory, and antipyretic properties. Lornoxicam differs from other oxicam compounds in its potent inhibition of prostaglandin biosynthesis, a property that explains the part
T1541 Drospirenone Drospirenone is a synthetic spironolactone analogue and progestin with progestational and anti-mineralocorticoid activity.
T1544 Olsalazine disodium Olsalazine sodium is bioconverted to 5-aminosalicylic acid (5-ASA) in the colon and has anti-inflammatory activity in ulcerative colitis.
T1555 Diclofenac sodium Diclofenac sodium is a non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt.
T1558 Resveratrol Resveratrol is a polyphenolic phytoalexin with antioxidant and potential chemopreventive activities.
T1574 Etoricoxib Etoricoxib is a synthetic, nonsteroidal anti-inflammatory drug (NSAID) with antipyretic, analgesic, and potential antineoplastic properties. Etoricoxib specifically binds to and inhibits the enzyme cyclooxygenase-2 (COX-2), resulting in inhibition of the conversion of arachidonic acid into prostagla
T1582 Naproxen Naproxen is a propionic acid derivative and a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, antipyretic and analgesic activities.
T1582L Naproxen sodium Naproxen is a COX inhibitor for COX-1 and COX-2 with analgesic and antipyretic properties.
T1586 Tenoxicam Tenoxicam, an antiinflammatory agent with analgesic and antipyretic properties, is used to treat osteoarthritis and control acute pain.
T1720 Amfenac Sodium Monohydrate Amfenac Sodium monohydrate is a non-steroidal analgesic anti-inflammatory drug with acetic acid moiety.
T1780 Parecoxib Parecoxib is an effective and selective COX-2 inhibitor.
T1867 ATB-346 ATB-346 is a novel hydrogen sulphide-releasing derivative of naproxen with markedly reduced toxicity.
T2225 4-Hydroxyantipyrine 4-Hydroxyantipyrine is formed during oxidative deamination of aminopyrine.
T2230 Paeoniflorin Paeoniflorin is a herbal constituent extracted from the root of Paeonia albiflora Pall.
T2403 Bromfenac sodium Bromfenac Sodium is the sodium salt form of bromfenac, a nonsteroidal anti-inflammatory drug (NSAID) with analgesic and anti-inflammatory activities. Upon ophthalmic administration, bromfenac binds to and inhibits the activity of cyclooxygenase II (COX II), an enzyme which converts arachidonic acid
T2550 Tolmetin Tolmetin is a Nonsteroidal Anti-inflammatory Drug. The mechanism of action of tolmetin is as a Cyclooxygenase Inhibitor. The chemical classification of tolmetin is Nonsteroidal Anti-inflammatory Compounds.
T2553 Etofenamate Etofenamate is a non-steroidal anti-inflammatory drug (NSAID) used for the treatment of joint and muscular pain.
T2826 Asarylaldehyde Asaraldehyde, a natural COX-2 inhibitor, exhibits 17-fold selectivity than COX-1.
T2972 Rutaecarpine Rutaecarpine is an inhibitor of COX-2 with IC50 of 0.28 μM.
T3214 NS-398 NS-398 is a COX-2 inhibitor wih anti-inflammatory activity.
T3332 Isosteviol Isosteviol, a common natural sweetener, belongs to tetracyclic diterpene glycosides. The pharmacology researches have suggested that stevioside and its hydrolysis products, steviol, isosteviol and steviolbioside, have many biological activities, such as reducing blood glucose, lowering blood pressur
T3342 Xanthohumol Xanthohumol, also known as 2', 4, 4'-trihydroxy-6'-methoxy-3'-prenylchalcone or desmethylxanthohumol, is a member of the class of compounds known as 3-prenylated chalcones. It inhibits COX-1 and COX-2 activity and shows chemopreventive effects.
T3417 Amentoflavone Amentoflavone, as a potent inhibitor of CYP3A4 and CYP2C9, can interact with many other medications. CYP3A4 and CYP2C9 are proteins used for drug metabolism in the body. Amentoflavone also is an inhibitor of human cathepsin B. It has antimalarial activity in trials significant affinities towards the
T3500 Flurbiprofen Axetil Flurbiprofen Axetil is an anti-inflammatory used as an analgesic.
T3883 Roburic acid Roburic acid and phenethyl-trans-ferulate inhibit COX-1 and COX-2.
T3884 Neoandrographolide Neoandrographolide has potent hypolipidemic effect and protects the cardiovascular without significant liver damage. Neoandrographolide has anti-inflammatory effect, might result from inhibition of iNOS and COX-2 expression through inhibiting p38 MAPKs activation. Neoandrographolide as chemosensitiz
T3981 Acacetin Acacetin is an O-methylated flavone found in various plants, shows antinociceptive, anti-inflammatory, and antioxidant activity in various research models.
T4092 Tyrphostin AG 126 The tyrphostin AG-126 selectively inhibits the phosphorylation of ERK1 (p44) and ERK2 (p42) at 25-50 μM. It blocks the production of TNF-α in vitro2 and in vivo, attenuating signaling through NF-κB, the induced expression of COX-2 and iNOS, and the inflammatory response in diverse animal models.
T4101 SC-560 SC-560 is a member of the diaryl heterocycle class of cyclooxygenase (COX) inhibitors.
T6387 Ampiroxicam Ampiroxicam is a nonselective cyclooxygenase inhibitor uesd as anti-inflammatory drug.
T6465 Dexamethasone Sodium Phosphate Dexamethasone, an interleukin receptor modulator, has anti-inflammatory and immunosuppressant effects. It belongs to a potent glucocorticoid class of steroid synthetic drugs.
T6540 Ibuprofen Lysine Ibuprofen Lysine is a non-steroidal anti-inflammatory drug.
T6574 Lumiracoxib Lumiracoxib is a novel, selective COX-2 inhibitor with IC50 and Ki of 0.14 μM and 0.06 μM, exhibits 515-fold selectivity over COX-1. Phase 4.
T6687 Suprofen Suprofen is an IBUPROFEN-type anti-inflammatory analgesic and antipyretic. It inhibits prostaglandin synthesis and has been proposed as an anti-arthritic.
T6737 Zaltoprofen Zaltoprofen is a Cox-1 and Cox-2 inhibitor, which is used for the treatment of arthritis.
T6893 MK-886 (L-663,536) MK-886 is an inhibitor of leukotriene biosynthesis, inhibiting 5-lipoxygenase-activating protein (FLAP). It is also a moderately potent PPARα antagonist.
T6970 RK-33 RK-33 is a first-in-class small molecule inhibitor of DDX3 (a RNA helicase) and causes G1 cell cycle arrest, induces apoptosis, and promotes radiation sensitization in DDX3-overexpressing cells.
T4313 Tinoridine hydrochloride Tinoridine (Y-3642) is a non-steroidal anti-inflammatory drug. Tinoridine (5-100 μM), produced a concentration-dependent inhibition on the simultaneous increases in lipid peroxide formation and renin release induced by 50 μM ascorbic acid in the renin granule fraction. On the other hand, indometha
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