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Androgen Receptor
T0135 Estradiol valerate β-estradiol 17-valerate (EV) is a synthetic estrogen. In hormone replacement therapy drugs, it is widely used in combination with other steroid hormones.
T0272 Nilutamide Nilutamide, an antineoplastic hormonal agent, is mainly used in the treatment of prostate Y. Nilutamide is a pure, nonsteroidal anti-androgen with affinity for androgen receptors, but not for estrogen, progestogen, or glucocorticoid receptors. Therefore, Nilutamide can block the action of androgens
T0380 Bicalutamide Bicalutamide, a synthetic, nonsteroidal antiandrogen, competitively binds to cytosolic androgen receptors in target tissues, thereby inhibiting the receptor binding of androgens.
T0476 Spironolactone Spironolactone is an Aldosterone Antagonist. The mechanism of action of spironolactone is as an Aldosterone Antagonist.
T0489 Flutamide Flutamide is an antiandrogen with about the same potency as cyproterone in rodent and canine species.
T0856 Dehydroepiandrosterone acetate Dehydroepiandrosterone acetate is a primary C19 steroid generated by the adrenal cortex.
T0856L Dehydroepiandrosterone Dehydroepiandrosterone (DHEA) has potential chemopreventive activity. Produced endogenously, DHEA  is an intermediate in the conversion of cholesterol to androgens and estrogens. Although the mechanisms of action of exogenously administered DHEA have not been fully illuminated, they may resul
T1167 Cyproterone acetate Cyproterone binds the androgen receptor (AR), thereby preventing androgen-induced receptor activation in target tissues and inhibiting the growth of testosterone-sensitive tumor cells. Cyproterone Acetate is the acetate salt of a synthetic steroidal antiandrogen with weak progestational and antineop
T1480 Danazol Danazol is a synthetic steroid with antigonadotropic and anti-estrogenic activities that acts as an anterior pituitary suppressant by inhibiting the pituitary output of gonadotropins. It possesses some androgenic properties. Danazol has been used in the treatment of endometriosis and some benign bre
T1541 Drospirenone Drospirenone is a synthetic spironolactone analogue and progestin with progestational and anti-mineralocorticoid activity.
T1596 Chlormadinone acetate Chlormadinone acetate is an orally active synthetic progestational hormone used often in combinations as an oral contraceptive.
T2108 Andarine Andarine (S-4) is an active partial agonist and an investigational selective androgen receptor modulator (SARM).
T2195 Epiandrosterone Epiandrosterone is a dehydroepiandrosterone metabolite and a precursor of testosterone and estradiol with hypolipidemic and anabolic property.
T2207 Adrenosterone Adrenosterone is a steroid hormone isolated from the adrenal cortex.
T2236 RU 58841 RU 58841 is a specific androgen receptor antagonist or anti-androgen; RU 58841 has a significant effect on hair regrowth.
T2339 ARN-509 Apalutamide is a small molecule and androgen receptor (AR) antagonist with potential antineoplastic activity.
T2408 MK-2866 (GTx-024) Ostarine is a non-steroidal agent with anabolic activity. Selective androgen receptor modulator (SARM) GTx-024 is designed to work like testosterone, thus promoting and/or maintaining libido, fertility, prostate growth, and muscle growth and strength. Mimicking testosterone's action, this agent may
T2991 3,3'-Diindolylmethane DIM (3,3'-diindolylmethane), a small molecule compound, is a proposed Y preventive agent.
T3017 Trenbolone acetate Trenbolone acetate is a synthetic androgen steroid with anabolic properties.
T3137 Boldenone Undecylenate Boldenone undecylenate is a synthetic steroid.
T3357 17 alpha-propionate 17 alpha-propionate is a new topical and peripherally selective androgen antagonist.
T3618 GSK-2881078 GSK2881078 is a selective androgen receptor modulator (SARM) that is being evaluated for effects on muscle growth and strength in subjects with muscle wasting to improve their physical function.
T6002 Enzalutamide (MDV3100) Enzalutamide is an Androgen Receptor Inhibitor (IC50: 36 nM). The mechanism of action of enzalutamide is as an Androgen Receptor Antagonist, and Cytochrome P450 3A4 Inducer, and Cytochrome P450 2C9 Inducer, and Cytochrome P450 2C19 Inducer.
T6400 AZD3514 AZD3514 is a potent and oral androgen receptor downregulator with Ki of 2.2 μM and has ability of reducing AR protein expression.Phase 1.
T6509 Galeterone Galeterone is an orally bioavailable small-molecule androgen receptor modulator and CYP17 lyase inhibitor with potential antiandrogen activity. Galeterone exhibits three distinct mechanisms of action: 1) as an androgen receptor antagonist, 2) as a CYP17 lyase inhibitor and 3) by decreasing overall a
T6829 EPI-001 EPI-001 is an androgen receptor N-terminal domain antagonist with IC50 of ~6 μM and a selective PPAR-gamma modulator.
T6889 MI-136 MI-136 inhibits expression of androgen receptor (AR) target genes that DHT induced.
T6915 ODM-201 ODM-201 is an androgen receptor (AR) antagonist that blocks AR nuclear translocation (Ki: 11 nM).
T4358 RAD140 RAD140 is an investigational selective androgen receptor modulator (SARM) for the treatment of conditions such as muscle wasting and breast cancer.
T7040 Angiotensin II human Angiotensin II is mediated by AT1 and AT2 receptors. AT1 and AT2 receptors have seven transmembrane glycoproteins with 30% sequence similarity.Angiotensin I convert Angiotensin II human through removing of two C-terminal residues by the enzyme angiotensin-converting enzyme (ACE).
T4357 LGD-3303 LGD-3303 is an androgen receptor modulator, with good oral bioavailability.
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