||Chloroquine diphosphate, used as an antimalarial drug, can increase the susceptibility of cancer cells to chemotherapy and radiation via inducing autophagy. According to reports, Chloroquine diphosphate is an adjuvant for chemotherapy and radiation for inducing cell autophagy to anti-Y cells metasta
||CGK 733 is a potent and selective inhibitor of ATM/ATR.
||AZ20 is an effective and specific inhibitor of ATR kinase (IC50: 5 nM, in a cell-free assay), 8-fold selectivity over mTOR.
||ETP-46464 is an effective and specific ATR inhibitor (IC50: 25 nM).
||Dactolisib is an orally bioavailable imidazoquinoline targeting the phosphatidylinositol 3 kinase (PI3K) and the mammalian target of rapamycin (mTOR), with potential antineoplastic activity.
||NU7026 is an effective DNA-PK inhibitor (IC50: 0.23 μM, in cell-free assays), 60-fold selective for DNA-PK than PI3K and no inhibition against both ATM and ATR.
||KU-60019, an analog of KU-55933, is a highly effective radiosensitizer with IC50 of 6.3 nM for ATM in cell-free assays, 270- and 1600-fold more selective for ATM than ATR and DNA-PK.
||PIK-93 is the first potent, synthetic PI4K inhibitor with IC50 of 19 nM; inhibits PI3Kα with IC50 of 39 nM.
||VE-822 has been used in trials studying the treatment of Ovarian Neoplasms, Ovarian Serous Tumor, Adult Solid Neoplasm, Advanced Solid Tumor, and Advanced Solid Neoplasm, among others.
||KU-55933 (ATM Kinase Inhibitor) is a potent and specific ATM inhibitor.
||Schisandrin B has an antioxidant effect on rodent liver and heart.
||VE-821, an effective and selective ATP competitive inhibitor of ATR( Ki=13 nM,IC50 =26 nM in cell-free assays), suppresses of H2AX phosphorylation.
||Mirin is a potent Mre11–Rad50–Nbs1 (MRN) complex inhibitor, and inhibits Mre11-associated exonuclease activity.
||AZD6738 is an orally active, and selective ATR kinase inhibitor with IC50 of 1 nM.
||Torin 2(IC50=0.25 nM), a specific and effective mTOR inhibitor, is the 800-fold greater specific activity for mTOR than PI3K and improves pharmacokinetic properties. The EC50 of Torin 2 for ATM/ATR/DNA-PK inhibition is 28 nM/35 nM/118 nM, respectively.
||CP-466722, an effective and reversible ATM inhibitor, does not inhibit ATR and PI3K or PIKK family members in cells.
||NU7441 (KU-57788) is a highly effective and specific DNA-PK inhibitor with IC50 of 14 nM. And NU7441 can inhibit PI3K with IC50 of 5 μM.
||NU6027 is a potent ATR/CDK inhibitor, inhibits CDK1/2, ATR and DNA-PK with Ki of 2.5 μM/1.3 μM, 0.4 μM and 2.2 μM, enter cells more readily than the 6-aminopurine-based inhibitors.
||AZD0156 , an effective and specific inhibitors of ATM kinase, is potential antineoplastic activities and chemo-/radio-sensitizing.
||GJ103 sodium salt
||GJ103 sodium salt is an active analog of the read-through compound GJ072.