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AMPK
T0740 Metformin hydrochloride Metformin HCl, a widely used anti-diabetic drug, has a potential function as an anti-Y medicine. Metformin inhibits the proliferation of a variety of Y cells including colon, prostate, ovarian, breast, and glioma lines.
T0800 Danthron Danthron is a natural product, regulates glucose, and lipid metabolism by activating AMPK.
T6291 WZ4003 WZ4003, a highly selective NUAK kinase inhibitor, is with IC50 of 20 nM and 100 nM for NUAK1 and NUAK2, respectively. It is no significant inhibition on 139 other kinases.
T6146 Dorsomorphin (Compound C) dihydrochloride Dorsomorphin(Ki=109 nM) is a specific, reversible, and effective AMPK inhibitor. It suppresses BMP type I receptor, but has no significant inhibition effect of several structurally related kinases including ZAPK, SYK, PKCθ, PKA, and JAK3.
T6854 GSK621 GSK621 is a specific and potent AMPK activator.
T4427 PF-06409577 PF-06409577 is an effective, orally active, and specific allosteric activator of AMPK (EC50: 7 nM, for α1β1γ1).
T2374 HTH-01-015 HTH-01-015 is a selective NUAK1 inhibitor (IC50=100 nM).
T1477 AICAR (Acadesine) Acadesine is an AMP-activated protein kinase activator which is used for the treatment of acute lymphoblastic leukemia and may have applications in treating other disorders such as diabetes.
T3863 Chikusetsusaponin IVa Chikusetsusaponin IVa is a novel AMPK activator, can induce insulin secretion from βTC3 cells via GPR4 mediated calcium and PKC pathways, may be developed into a new potential for therapeutic agent used in T2DM patients.
T3676 Sesamol Sesamol could decrease lung inflammation and lipopolysaccharide (LPS)-induced lung injury in rats. Sesamol ameliorates inflammatory and oxidative damage by upregulating AMPK activation and Nrf2 signaling and blocking the NF-κB and MAPK signaling pathways and inhibits melanin biosynthesis by down-r
T2133 Adenosine 5'-monophosphate Adenosine 5'-monophosphate is an ester of phosphoric acid with the nucleoside adenosine.
T1453 Phenformin hydrochloride Phenformin is an agent belonging to the biguanide class of antidiabetics with antihyperglycemic activity.
T2468 A-769662 A-769662 is an effective, reversible AMPK activator(EC50=0.8 μM).
T1977 BML-275 Dorsomorphin is an effective and specific inhibitor of AMPK (AMP-activated protein kinase), which is induced by AICAR and metformin.
T6129 GSK1070916 GSK1070916 is a reversible and ATP-competitive inhibitor of Aurora B/C with IC50 of 3.5 nM/6.5 nM. It displays >100-fold selectivity against the closely related Aurora A-TPX2 complex. Phase 1.
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