||Metformin HCl, a widely used anti-diabetic drug, has a potential function as an anti-Y medicine. Metformin inhibits the proliferation of a variety of Y cells including colon, prostate, ovarian, breast, and glioma lines.
||Danthron is a natural product, regulates glucose, and lipid metabolism by activating AMPK.
||WZ4003, a highly selective NUAK kinase inhibitor, is with IC50 of 20 nM and 100 nM for NUAK1 and NUAK2, respectively. It is no significant inhibition on 139 other kinases.
||Dorsomorphin (Compound C) dihydrochloride
||Dorsomorphin(Ki=109 nM) is a specific, reversible, and effective AMPK inhibitor. It suppresses BMP type I receptor， but has no significant inhibition effect of several structurally related kinases including ZAPK, SYK, PKCθ, PKA, and JAK3.
||GSK621 is a specific and potent AMPK activator.
||PF-06409577 is an effective, orally active, and specific allosteric activator of AMPK (EC50: 7 nM, for α1β1γ1).
||HTH-01-015 is a selective NUAK1 inhibitor (IC50=100 nM).
||Acadesine is an AMP-activated protein kinase activator which is used for the treatment of acute lymphoblastic leukemia and may have applications in treating other disorders such as diabetes.
||Chikusetsusaponin IVa is a novel AMPK activator, can induce insulin secretion from βTC3 cells via GPR4 mediated calcium and PKC pathways, may be developed into a new potential for therapeutic agent used in T2DM patients.
||Sesamol could decrease lung inflammation and lipopolysaccharide (LPS)-induced lung injury in rats. Sesamol ameliorates inflammatory and oxidative damage by upregulating AMPK activation and Nrf2 signaling and blocking the NF-κB and MAPK signaling pathways and inhibits melanin biosynthesis by down-r
||Adenosine 5'-monophosphate is an ester of phosphoric acid with the nucleoside adenosine.
||Phenformin is an agent belonging to the biguanide class of antidiabetics with antihyperglycemic activity.
||A-769662 is an effective, reversible AMPK activator(EC50=0.8 μM).
||Dorsomorphin is an effective and specific inhibitor of AMPK (AMP-activated protein kinase), which is induced by AICAR and metformin.
||GSK1070916 is a reversible and ATP-competitive inhibitor of Aurora B/C with IC50 of 3.5 nM/6.5 nM. It displays >100-fold selectivity against the closely related Aurora A-TPX2 complex. Phase 1.