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ALK
T2612 CEP-28122 CEP-28122 is a highly potent and selective orally active ALK inhibitor.
T1791 LDK378(Ceritinib) Ceritinib is a Kinase Inhibitor. The mechanism of action of Ceritinib is as a Tyrosine Kinase Inhibitor, and Cytochrome P450 3A Inhibitor, and Cytochrome P450 2C9 Inhibitor.
T1935 LDN193189 LDN193189(DM 3189) is a selective BMP signaling inhibitor, inhibiting the transcriptional activity of the BMP type I receptors ALK2 and ALK3.
T1943 ML347 ML347(DN193719) is a highly specific ALK1/2 inhibitor ( IC50: 46/32 nM), and the selectivity for ALK2 is >300-fold than ALK3.
T6158 LDN-193189 hydrochloride LDN193189 hydrochloride is a selective BMP type I receptor kinases inhibitor.
T1962 ASP 3026 ASP3026 has been used in trials studying the treatment of Solid Tumor, B-Cell Lymphoma, Advanced Malignancies, Positive for Anaplastic Lymphoma Kinase, and Positive for Proto-Oncogene Tyrosine-Protein Kinase ROS.
T3678 Entrectinib Entrectinib is an inhibitor of TrkA (IC50: 1.7 nM), TrkB (IC50: 0.1 nM), and TrkC (IC50: 0.1 nM), as well as anaplastic lymphoma kinase (ALK; IC50: 1.6 nM) and C-ros oncogene 1 (ROS1; IC50: 0.2 nM). Entrectinib blocks proliferation of ALK-dependent cell lines, including those with C1156Y or L1196M r
T3079 GSK1838705A GSK1838705A is an effective IGF-1R inhibitor (IC50: 2.0 nM), modestly potent to IR (IC50: 1.6 nM) and ALK (IC50: 0.5 nM), respectively, and little inhibition to other protein kinases.
T3621 Brigatinib Brigatinib is a highly potent and selective ALK inhibitor.
T3059 AP26113 Brigatinib is a excellently effective and specific ALK inhibitor( IC50 =0.6 nM).
T1942 DMH-1 DMH-1 is a potent and selective BMP inhibitor.
T1936 CH5424802 CH5424802 is an orally available inhibitor of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) with antineoplastic activity.
T6496 EW-7197 Vactosertib is an orally bioavailable inhibitor of the serine/threonine kinase, transforming growth factor (TGF)-beta receptor type 1 (TGFBR1), also known as activin receptor-like kinase 5 (ALK5), with potential antineoplastic activity.
T1967 AZD-3463 AZD3463, an orally bioavailable ALK inhibitor (Ki: 0.75 nM), can inhibit IGF1R with equivalent potency.
T4015 HG-14-10-04 HG-14-10-04 is a potent and specific ALK inhibitor.
T4257 Belizatinib Belizatinib is an effective, oral and dual inhibitor of ALK (IC50: 0.7?nM, wild-type recombinant ALK) and TRKA, TRKB, and TRKC.
T3550 Ensartinib Ensartinib (X-396) is an orally available small molecule inhibitor of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) with potential antineoplastic activity. Upon oral administration, X-396 binds to and inhibits ALK kinase, ALK fusion proteins, and ALK point mutation variants. Inhibiti
T2655 CEP-37440 CEP-37440 is an effective and specific Dual FAK/ALK inhibitor with IC50s of 120 nM(ALK cellular in 75% human plasma) and 2.3 nM (FAK).
T1914 K02288 K02288 is a novel small molecule inhibitor of ALK1/2/3/6.
T1900 LDN-212854 LDN-212854, a novel BMP inhibitor, exhibits greater selectivity for BMP versus the TGF-β type I receptors; possesses differences towards ALK2(IC50=1.3 nM) versus ALK1/3 compared to other inhibitors.
T3061 PF-06463922 PF-06463922 is an orally available, ATP-competitive inhibitor of the receptor tyrosine kinases, anaplastic lymphoma kinase (ALK) and C-ros oncogene 1 (Ros1), with potential antineoplastic activity.
T2641 KRCA-0008 KRCA-0008 is an effective and specific ALK/Ack1 inhibitor (IC50: 12/4 nM); displays drug-like properties without hERG liability.
T1944 LDN-214117 LDN-214117 is a potent and selective ALK2 inhibitor.
T4071 TPX-0005 TPX-0005 is a potent ALK/ROS1/TRK inhibitor, with IC50 of 1.01 nM, 5.3 nM, 1.08 nM and 1.26 nM for WT ALK, SRC, ALK L1196M and ALK G1202R, respectively.
T1726 SB-431542 SB431542 is an effective and selective inhibitor of ALK5 (IC50: 94 nM) in a cell-free assay, and also inhibits TGF-β Receptor.
T2449 D4476 D4476 is an effective, selective, and cell-permeant CK1 (casein kinase 1) inhibitor( IC50=300 nM in a cell-free assay).
T6337 RepSox RepSox is a potent and selective of the TGFβR-1/ALK5 inhibitor.
T1800 GW788388 GW788388 is a potent and selective inhibitor of ALK5, also inhibits TGF-(beta) type II receptor and activin type II receptor activities.
T2098 A 77-01 A 77-01 is a potent inhibitor of TGF-(beta) type I receptor superfamily activin-like kinase ALK5 with IC50 of 25 nM.
T2462 SB-505124 SB505124 is a selective inhibitor of TGFβR for ALK4, ALK5.
T3041 ALK inhibitor 2 ALK inhibitor 2 is a new-type and selective inhibitor for the ALK kinase.
T2251 NVP-TAE 684 NVP-TAE 684 is a excellently effective and specific ALK inhibitor(IC50=3 nM).
T1661 Crizotinib Crizotinib is a Kinase Inhibitor. The mechanism of action of crizotinib is as a Cytochrome P450 3A Inhibitor, and Receptor Tyrosine Kinase Inhibitor, and Cytochrome P450 2B6 Inhibitor, and P-Glycoprotein Inhibitor, and Organic Cation Transporter 1 Inhibitor, and Organic Cation Transporter 2 Inhibito
T3031 A 83-01 A 83-01 is a selective inhibitor of TGF-β type I receptor ALK5 kinase, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7 with IC50 values of 12 nM, 45 nM and 7.5 nM, respectively.
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