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5-HT Receptor
T0025 Haloperidol Haloperidol is a highly potent neuroleptic by relieving nervous through the depression of nerve function. In addition, haloperidol has shown about 50-fold efficacy than chlorpromazine, another antipsychotic drug. Haloperidol has some potencies in the treatment of delusions and hallucinations. Its ef
T0031 Ziprasidone hydrochloride monohydrate Ziprasidone(CP88059) is a united 5-HT (serotonin) and dopamine receptor antagonist which shows potent effects of the antipsychotic activity.
T0031L Ziprasidone hydrochloride Ziprasidone (hydrochloride) is a united 5-HT (serotonin) and dopamine receptor antagonist which shows potent effects of antipsychotic activity.
T0031L2 Ziprasidone Ziprasidone is an a typical antipsychotic used in the treatment of schizophrenia and bipolar disorder. Use of ziprasidone has not been consistently associated with serum enzyme elevations and has yet to be linked to instances of clinically apparent acute liver injury.
T0039 Dapoxetine Dapoxetine is a selective serotonin reuptake inhibitor, for the treatment of premature ejaculation.
T0074 Chlorprothixene Chlorprothixene is a typical antipsychotic drug of the thioxanthene class,which was the first of the series to be synthesized.
T0074L Chlorprothixene hydrochloride Chlorprothixene brings strong blocking effects by blocking the 5-HT2 D1, D2, D3, histamine H1, muscarinic and alpha1 adrenergic receptors. Chlorprothixene is a typical antipsychotic drug of the thioxanthene (tricyclic) class.
T0076 Paliperidone Paliperidone(Invega) is used as an atypical antipsychotic. It applies to the acute and maintenance treatment of schizophrenia. Chemically, paliperidone is the primary active metabolite of the older atypical antipsychotic risperidone.
T0081 Lafutidine Lafutidine is a newly developed histamine H(2)-receptor antagonist, which can inhibit gastric acid secretion.
T0088 Urapidil hydrochloride Urapidil hydrochloride is 5-HT1A receptor agonist and an α1-adrenoceptor antagonist.
T0113 Mebhydrolin napadisylate Mebhydrolin (napadisylate) is an antihistamine used to relieve allergic symptoms caused by histamine release, including nasal allergies and allergic dermatosis.
T0137 Mirtazapine Mirtazapine is a tetracyclic antidepressant with a somewhat unique mechanism of action. Mirtazapine therapy can be associated with transient asymptomatic elevations in serum aminotransferase levels and has been linked to rare instances of clinically apparent acute liver injury.
T0162 Quetiapine Quetiapine is used for the therapy of schizophrenia, and for the treatment of acute manic episodes associated with bipolar I disorder. The mechanism of quetiapine' action is thought by mediated through antagonist activity at serotonin and dopamine receptors. Specifically, the D1 and D2 dopamine, the
T0165 Urapidil Urapidil, a sympatholytic antihypertensive drug, acts as a 5-HT1A receptor agonist and as an α1-adrenoceptor antagonist.
T0172 Maprotiline hydrochloride Maprotiline hydrochloride is a bridged-ring tetracyclic antidepressant that is both mechanistically and functionally similar to the tricyclic antidepressants, including side effects associated with its use.
T0174 Cyproheptadine hydrochloride Cyproheptadine hydrochloride sesquihydrate, an antihistamine, is an antagonist of serotonin and histamine2.
T0185 Escitalopram Escitalopram is a furancarbonitrile that is one of the SEROTONIN UPTAKE INHIBITORS used as an antidepressant. The drug is also effective in reducing ethanol uptake in alcoholics and is used in depressed patients who also suffer from tardive dyskinesia in preference to tricyclic antidepressants, whic
T0203 Sumatriptan succinate Sumatriptan succinate, a serotonin1 (5-HT1) receptor agonist, is used in the acute treatment of a migraine headache.
T0204 Protriptyline hydrochloride Protriptyline Hydrochloride is the hydrochloride salt form of protriptyline, a tricyclic secondary amine with an antidepressant property. Protriptyline hydrochloride blocks the re-uptake of norepinephrine and serotonin by nerve terminals, thereby increasing available norepinephrine and serotonin. In
T0205 Brompheniramine hydrogen maleate Brompheniramine maleate is an antagonist against histamine H1 receptors.
T0216 Eletriptan HBr Eletriptan hydrobromide is an orally active agonist with specific affinity for the 5-hydroxytriptamine1B/1D receptor.
T0217 Levodropropizine Levodropropizine is a histamine receptor inhibitor. It is used as an effective and very well tolerated peripheral antitussive drug.
T0225 Pizotifen Malate Pizotifen malate, a highly selective 5-HT receptor blocking agent, is a drug based on benzocycloheptane.
T0236 Azatadine Maleate(Azatadine dimaleate) Azatadine dimaleate is an inhibitor for histamine(IC50=6.5 nM) and cholinergic(IC50=10 nM).
T0255 Clomipramine hydrochloride Clomipramine hydrochloride is a tricyclic antidepressant similar to IMIPRAMINE that selectively inhibits the uptake of serotonin in the brain. It is readily absorbed from the gastrointestinal tract and demethylated in the liver to form its primary active metabolite, desmethylclomipramine.
T0302 Triflupromazine hydrochloride Triflupromazine hydrochloride, an antipsychotic medication, is Dopamine D1/D2 receptor antagonists.
T0318 Azacyclonol Azacyclonol is a drug used to diminish hallucinations in psychotic individuals.
T0333 Aniracetam Aniracetam(Ro 13-5057), a nootropic and neuroprotective drug, selectively modulates the AMPA receptor and nAChR.
T0338 Minaprine dihydrochloride Minaprine is a reversible inhibitor of MAO-A, used in the treatment of various depressive states.
T0351 Risperidone Risperidone is a selective blocker of dopamine D2 receptors and serotonin 5-HT2 receptors that act as an atypical antipsychotic agent.
T0365 Thioridazine hydrochloride Thioridazine, an antipsychotic drug, is used in the therapy of psychosis and schizophrenia and shows serotonin antagonism or D4 selectivity.
T0370 Pheniramine maleate Pheniramine Maleate,an alkylamine derivative with antihistaminic and vasodilatory properties,binds to histamine H1 receptors, thereby inhibiting phospholipase A2 and production of the endothelium-derived relaxing factor, nitric oxide.
T0428 Alverine citrate Alverine Citrate is utilized in functional gastrointestinal disorders.
T0445 Promethazine Tafluprost(AFP-168) is an analogue of anti-glaucoma prostaglandin (PG) .
T0450 Fluoxetine Fluoxetine is the first highly specific serotonin uptake inhibitor. It is used as an antidepressant and often has a more acceptable side-effects profile than traditional antidepressants.
T0450L Fluoxetine hydrochloride Fluoxetine is the first highly specific serotonin uptake inhibitor. It is used as an antidepressant and often has a more acceptable side-effects profile than traditional antidepressants.
T0472 Venlafaxine hydrochloride Venlafaxine hydrochloride is a cyclohexanol and phenylethylamine derivative that functions as a SEROTONIN AND NORADRENALINE REUPTAKE INHIBITOR (SNRI) and is used as an ANTIDEPRESSIVE AGENT.
T0482 Sertraline hydrochloride Sertraline hydrochloride is a selective serotonin uptake inhibitor that is used in the treatment of depression.
T0525 Flopropione Flopropione, a spasmolytic or antispasmodic agent, is used as a 5-HT1A receptor antagonist.
T0647 Tryptamine Tryptamine is a monoamine alkaloid found in animals, plants, and fungi. It contains an indole ring structure and is structurally analogous to the tryptophan. It is found in trace amounts in the brains of mammals and is recognized to play a role as a neurotransmitter or neuromodulator.
T0663 2-Bromo-6-methoxynaphthalene 2-Bromo-6-methoxynaphthalene was used in the synthesis of nabumetone [4-(6-methoxy-2-naphthalenyl)-2-butanone] by Heck reaction.
T0678 Amitriptyline hydrochloride Amitriptyline Hydrochloride is the hydrochloride salt of the tricyclic dibenzocycloheptadiene amitriptyline with antidepressant and antinociceptive activities.
T0680 Lamotrigine Lamotrigine is an Anti-epileptic Agent and Mood Stabilizer. The physiologic effect of lamotrigine is by means of Decreased Central Nervous System Disorganized Electrical Activity.
T0716 Molindone hydrochloride Molindone hydrochloride is an indole derivative effective in schizophrenia and other psychoses by blocking the effects of dopamine in the brain.
T0723 Cloperastine hydrochloride Cloperastine hydrochloride is a type of flavonoid.
T0735 Pindolol Pindolol is a moderately lipophilic beta blocker (ADRENERGIC BETA-ANTAGONISTS). It is non-cardioselective and has intrinsic sympathomimetic actions, but little membrane-stabilizing activity.
T0766 Promazine hydrochloride Promazine hydrochloride is a phenothiazine with actions similar to CHLORPROMAZINE but with less antipsychotic activity. It is primarily used in short-term treatment of disturbed behavior and as an antiemetic.
T0783 Mianserin hydrochloride Mianserin hydrochloride is a tetracyclic compound with antidepressant effects. it apparently blocks alpha-adrenergic, histamine H1, and some types of serotonin receptors. It may cause drowsiness and hematological problems.
T0785 Dexchlorpheniramine Maleate Dexchlorpheniramine (trade name Polaramine) is an antihistamine with anticholinergic properties used to treat allergic conditions such as hay fever or urticaria. It is the pharmacologically active dextrorotatory isomer of chlorpheniramine.
T0802 Procaine hydrochloride Procaine Hydrochloride is the hydrochloride salt form of procaine, a benzoic acid derivative with local anesthetic and antiarrhythmic properties. Procaine binds to and inhibits voltage-gated sodiumchannels, thereby inhibiting the ionic flux required for the initiation and conduction of impuls
T0811 Amisulpride Amisulpride (trade name Solian) is an antipsychotic drug sold by Sanofi-Aventis. It is not approved for use in the United States, but is approved for use in Europe and Australia for the treatment of psychoses and schizophrenia. Additionally, it is approved in Italy for the treatment of dysthymia (
T0869 Atomoxetine hydrochloride Atomoxetine Hydrochloride is the hydrochloride salt of atomoxetine, a phenoxy-3-propylamine derivative and selective non-stimulant, norepinephrine reuptake inhibitor with cognitive-enhancing activity. Although its precise mechanism of action is unknown, atomoxetine appears to selectively inhib
T0965 Histamine Histamine is an amine derived by enzymatic decarboxylation of HISTIDINE. It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and also a centrally acting neurotransmitter.
T0991 Desipramine hydrochloride Desipramine Hydrochloride a secondary amine tricyclic antidepressant (TCA), is the hydrochloride salt form of desipramine. In the central nervous system (CNS), desipramine hydrochloride blocks the re-uptake of neurotransmitters, including norepinephrine and serotonin. This leads to an increase in th
T1042 Granisetron hydrochloride Granisetron hydrochloride is a serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic for cancer chemotherapy patients.
T1045 Trimipramine maleate Trimipramine maleate appears to inhibit serotonin transport and norepinephrine uptake by nerve terminals. This increases available norepinephrine or serotonin and prolongs its action. Trimipramine Maleate is the maleate salt form of trimipramine, a tricyclic secondary amine of the dibenzazepine clas
T1066 Ketanserin Ketanserin is a quinazoline derivative and serotonin (5-hydroxytryptamine, 5HT) receptor subtype 2 (5-HTR2) antagonist with potential antihypertensive and antiplatelet activities. Following administration, ketanserin binds to and inhibits the signaling mediated by 5-HTR2, which inhibits serotonin-de
T1069 Metoclopramide hydrochloride Metoclopramide hydrochloride is a selective dopamine D2 receptor antagonist, used as an antiemetic.
T1077 Fluvoxamine maleate Fluvoxamine maleate is a selective serotonin reuptake inhibitor that is used in the treatment of depression and a variety of anxiety disorders.
T1081 Nafronyl oxalate Nafronyl oxalate is a drug used in the management of peripheral and cerebral vascular disorders. It is claimed to enhance cellular oxidative capacity and to be a spasmolytic. It may also be an antagonist at 5HT-2 serotonin receptors.
T1092 Zolmitriptan Zolmitriptan selectively binds to and activates serotonin (5-HT) 1B receptors expressed in intracranial arteries and 5-HT 1D receptors located on peripheral trigeminal sensory nerve terminals in the meninges and central terminals in brainstem sensory nuclei. Zolmitriptan is a member of the triptan c
T1156 Palonosetron hydrochloride Palonosetron is a 5-HT3 antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting.
T1170 Olopatadine hydrochloride Olopatadine hydrochloride is an antihistamine with mast-cell stabilizing properties used as eye drops in the treatment of ALLERGIC CONJUNCTIVITIS.
T1173 Tropisetron hydrochloride Tropisetron Hydrochloride is the hydrochloride salt form of tropisetron, a selective, competitive serotonin 5-hydroxytryptamine type 3 (5-HT3) receptor antagonist, with antinauseant and antiemetic activities.
T1180 Blonanserin Blonanserin is an atypical antipsychotic approved in Japan in January, 2008. Relative to many other antipsychotics, blonanserin has an improved tolerability profile, lacking side effects such as extrapyramidal symptoms, excessive sedation, or hypotension.
T1266 Terfenadine Terfenadine is a prodrug that is metabolized by intestinal CYP3A4 to the active form fexofenadine, a selective histamine H1-receptor antagonist with antihistaminic and non-sedative effects.
T1279 Vilazodone Vilazodone is a selective serotonin (5-HT) reuptake inhibitor (SSRI) and a 5-HT-1A receptor partial agonist, with antidepressant and anti-anxiety activities. Vilazodone inhibits the reuptake of serotonin from the synaptic cleft while stimulating the release of 5-HT into the synaptic cleft. This incr
T1291 Cisapride Cisapride is a serotonin type 4 (5-HT4) receptor agonists are potent prokinetic agents that act on serotonin receptors in the intestine and promote intestinal peristalsis, increase gastric emptying and decrease esophageal reflux.
T1327 Nortriptyline hydrochloride Nortriptyline hydrochloride is a metabolite of AMITRIPTYLINE that is also used as an antidepressive agent. Nortriptyline is used in major depression, dysthymia, and atypical depressions.
T1354 N-Acetyl-5-hydroxytryptamine N-Acetylserotonin (NAS), also known as normelatonin, is a naturally occurring chemical intermediate in the endogenous production of melatonin from serotonin. It is produced from serotonin by the enzyme aralkylamine N-acetyltransferase
T1384 Chlorpromazine hydrochloride Chlorpromazine hydrochloride is the prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking DOPAMINE RECEPTORS. Chlorpromazine has several other actions and therape
T1412 Loxapine succinate salt Loxapine succinate, a D2DR and D4DR inhibitor, is utilized in schizophrenia.
T1442 Pizotifen Pizotifen is a strong serotonin and tryptamine antagonist, with weak anticholinergic, anti-histaminic and anti-kinin effects. It also possesses sedative and appetite-stimulating properties. Pizotifen hydrochloride is an active ingredient in Sandomigran, which is used for the prophylactic management
T1445 Agomelatine Agomelatine is structurally closely related to melatonin. Agomelatine is a potent agonist at melatonin receptors and an antagonist at serotonin-2C (5-HT2C) receptors, tested in an animal model of depression.
T1471 Duloxetine hydrochloride Duloxetine hydrochloride is a thiophene derivative and selective neurotransmitter uptake inhibitor for SEROTONIN and NORADRENALINE (SNRI). It is an ANTIDEPRESSIVE AGENT and ANXIOLYTIC and is also used for the treatment of pain in patients with DIABETES MELLITUS and FIBROMYALGIA.
T1478 Ondansetron hydrochloride dihydrate Ondansetron hydrochloride is a competitive serotonin type 3 receptor antagonist. It is effective in the treatment of nausea and vomiting caused by cytotoxic chemotherapy drugs, including cisplatin, and has reported anxiolytic and neuroleptic properties.
T1483 Citalopram hydrobromide Citalopram, a selective serotonin reuptake inhibitor (SSRI), selectively inhibits the CNS neuronal reuptake of serotonin, thereby potentiating serotonergic activity in the central nervous system (CNS). Citalopram Hydrobromide is the orally bioavailable hydrobromide salt of the racemic bicyclic phtha
T1509 Cyclobenzaprine hydrochloride Cyclobenzaprine Hydrochloride, a centrally acting muscle relaxant with antidepressant activity, leads to a reduction in muscle spasms.
T1512 Rizatriptan benzoate Rizatriptan benzoate selectively binds to and activates serotonin (5-HT) 1B receptors and 5-HT 1D receptors providing relief of migraine headaches.
T1528 Azasetron hydrochloride Azasetron Hydrochloride is a 5-HT3 receptor antagonist which is used as an anti-emetic.
T1540 Doxepin hydrochloride Doxepin Hydrochloride is a dibenzoxepin tricyclic compound. It displays a range of pharmacological actions including maintaining adrenergic innervation. Its mechanism of action is not fully understood, but it appears to block reuptake of monoaminergic neurotransmitters into presynaptic terminals. It
T1551 Tegaserod maleate Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. Its use was the only drug approved by the United States Food and Drug Administration to help relieve the abdominal discomfort, bloating and constipation associated with irr
T1566 Aripiprazole Aripiprazole is an antipsychotic agent that is structurally related to piperazines and quinolones. It is a partial agonist of SEROTONIN RECEPTOR, 5-HT1A and DOPAMINE D2 RECEPTORS, where it also functions as a post-synaptic antagonist, and an antagonist of SEROTONIN RECEPTOR, 5-HT2A.
T1567 Olanzapine Olanzapine is an atypical antipsychotic that is used currently in the treatment of schizophrenia and bipolar illness.
T1580 Desvenlafaxine Desvenlafaxine is a cyclohexanol and phenol derivative and metabolite of venlafaxine that functions as a serotonin and noradrenaline reuptake inhibitor (SNRI) and is used as an antidepressive agent.
T1619 Trazodone hydrochloride Trazodone hydrochloride is a serotonin uptake inhibitor that is used as an antidepressive agent. It has been shown to be effective in patients with major depressive disorders and other subsets of depressive disorders. It is generally more useful in depressive disorders associated with insomnia and a
T1636 Paroxetine hydrochloride Paroxetine hydrochloride is a serotonin uptake inhibitor that is effective in the treatment of depression.
T1644 Dopamine hydrochloride Dopamine is a naturally occurring catecholamine formed by decarboxylation of dihydroxyphenylalanine and a precursor of norepinephrine and epinephrine. Dopamine binds to alpha-1- and beta-1- adrenergic receptors.
T1735 Lurasidone hydrochloride Lurasidone hydrochloride is a thiazole derivative and atypical antipsychotic agent that functions as a dopamine D2 receptor antagonist; serotonin 5-HT2 receptor antagonist, serotonin 5-HT7 receptor antagonist, an antagonist of the adrenergic α2A and α2C receptors, as well as a partial serotonin 5-
T1769 Pardoprunox Pardoprunox is a partial dopamine D2 agonist and noradrenergic agonist with serotonin 5-HT1A agonist properties. Pardoprunox has been used in trials studying the treatment of Early Stage Parkinson's Disease and Advanced Stage Parkinson's Disease.
T1774 SB-742457 SB742457 is a highly selective 5-HT6 receptor antagonist, used in trials studying the treatment of Alzheimer's Disease.
T1951 Asenapine Maleate Asenapine is a second generation (atypical) antipsychotic agent that is taken sublingually and used in the treatment of schizophrenia and manic or mixed episodes associated with bipolar 1 disorder. Asenapine is associated with a low rate of transient and mild serum aminotransferase elevations during
T2076 Pimavanserin Pimavanserin(ACP-103) is an effective and specific 5-HT2A receptor inverse agonist (mean pIC50: 8.7, in the cell-based functional assay). Pimavanserin is an atypical antipsychotic used in the treatment of hallucinations and psychosis in patients with Parkinson disease.
T2092 Amitifadine hydrochloride Amitifadine hydrochloride is a triple reuptake inhibitor (TRI) or serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI).
T2132 Buspirone hydrochloride Buspirone is a 5HT(1A) receptor agonist, used to treat generalized anxiety disorder (GAD).
T2190 Methiothepin mesylate Methiothepin mesylate is a potent and non-selective 5-HT2 receptor antagonist,used as an antipsychotic.
T2209 Serotonin hydrochloride Serotonin hydrochloride is an endogenous 5-HT receptor agonist, a monoamine neurotransmitter in the CNS,and a catechol O-methyltransferase (COMT) inhibitor(Ki=44 μM).
T2278 Piboserod Piboserod (SB 207266) is a selective 5-HT(4) receptor antagonist.
T2289 RU 24969 hemisuccinate RU 24969 is a selective agonist at the 5-HT1A and 5-HT1B receptors.
T2306 Brexpiprazole Brexpiprazole is a partial agonist of human 5-hydroxytryptamine (5-HT) 5-HT1A and dopamine D2 receptors.
T2317 Almotriptan Malate Almotriptan Malate, a selective 5-HT1B/1D receptor agonist, is used in the therapy of Migraine attacks in adults.
T2344 LY 344864 LY344864, a specifc receptor agonist, is an affinity of 6 nM (Ki) at the recently cloned 5-HT1F receptor.
T2395 Vortioxetine Vortioxetine is a serotonergic antidepressant used for major depression disorders. Vortioxetine has been associated with a low rate of minor serum aminotransferase elevations during treatment.
T2395L Vortioxetine HBr Vortioxetine (Lu AA21004) is a serotonin (5-HT) modulator and stimulator (SMS), inhibits 5-HT1A/1B/3A/7 receptor and SERT (IC50: 15/33/3.7/19/1.6 nM).
T2402 Tianeptine sodium Tianeptine sodium is a selective serotonin reuptake enhancer (SSRE), used to treat major depressive episodes.
T2428 TG6-10-1 TG6-10-1 is an EP2 antagonist.
T2459 BRL 54443 BRL 54443 is a potent 5-HT1E/1F receptor agonist (pKi values are 8.7 and 8.9 respectively).
T2525 Alosetron hydrochloride Alosetron Hydrochloride is the hydrochloride salt form of alosetron, a potent and selective 5-HT3 receptor antagonist. Alosetron blocks the actions of serotonin at 5-HT3 sites in the peripheral nervous system, particularly on enteric and nociceptive sensory neurons, thereby affecting the regulation
T2542 Prucalopride Prucalopride is a selective, high-affinity 5-HT4A/4B receptor agonist (Ki: 2.5/8 nM). It has >290-fold selectivity for 5-HT4A/4B receptor than other 5-HT receptor subtypes.
T2565 Hesperetin Hesperetin belongs to the flavanone class of flavonoids. Hesperetin, in the form of its glycoside hesperidin, is the predominant flavonoid in lemons and oranges.
T2589 Dalasetron Mesylate Hydrate Dolasetron mesylate, a selective serotonin receptor antagonist, competitively blocks the action of serotonin at 5HT3 receptors, resulting in suppression of chemotherapy- and radiotherapy-induced nausea and vomiting.
T2599 Pirenperone Pirenperone is a putative 5-HT2 receptor antagonist with the central antiserotonergic and antidopaminergic action.
T2631 WAY-100635 Maleate WAY-100635 is a specific and effective 5-HT receptor antagonist (IC50=0.95 nM).
T2688 LY310762 LY310762 is a 5-HT1D receptor antagonist with Ki of 249 nM.
T2714 Rotundine Rotundine is extracted from Corydalis yanhusuo W. T. Wang.
T2874 Tetrahydroberberine Tetrahydroberberine is an isoquinoline alkaloid isolated from corydalis tuber, has a micromolar affinity for dopamine D(2) receptors.
T3046 BMY 7378 dihydrochloride BMY-7378, α1D-adrenergic receptor antagonist, is a weak partial agonist/antagonist of 5-HT1A receptor.
T3085 Piperacetazine Piperacetazine, an antipsychotic prodrug, is used forschizophrenia.
T3086 Mesoridazine Besylate Mesoridazine (Serentil) is a piperidine neuroleptic drug belonging to the class of drugs called phenothiazines, used in the treatment of schizophrenia. It is a metabolite of thioridazine.
T3179 F 11440 F 11440 is a highly effective and selective 5-HT1A receptor agonist with marked antidepressant and anxiolytic potential.
T3183 WAY-181187(SAX-187) WAY-181187 has high-affinity binding at the human 5-HT6 receptor.
T3269 Metadoxine Metadoxine is a neurotransmitter stimulant.
T3275 Nefazodone hydrochloride Nefazodone is a serotoninergic modulating antidepressant that is used in therapy of depression, aggressive behavior and panic disorder.
T3341 Elemicin Elemicin is a constituent of several plant species' essential oils with anticholinergic effects in human.
T3369 Nuciferine Nuciferine is an alkaloid found within the plants Nymphaea caerulea and Nelumbo nucifera. It has a profile of action associated with dopamine receptor blockade.
T3431 Pardoprunox hydrochloride Pardoprunox hydrochloride is a novel partial dopamine D2 and D3 receptor agonist and serotonin 5-HT1A receptor agonist, D2 (pKi = 8.1) and D3 receptor (pKi = 8.6) partial agonist and 5-HT1A receptor (pKi = 8.5) full agonist.
T3453 WAY-100635 maleate salt WAY-100635 maleate is a effective and elective 5-hydroxytryptamine1A antagonist ( IC50=0.95 ± 0.12 nM).
T3526 Dasotraline hydrochloride Dasotraline hydrochloride (SEP-225289 hydrochloride) is a triple reuptake inhibitor  that inhibits dopamine, norepinephrine, and serotonin transporters with IC50 values of 4, 6, and 11 nM, respectively.
T3648 YL0919 YL0919 is a novel antidepressant candidate with dual activity as a 5-HT1A receptor agonist and a selective serotonin reuptake inhibitor.
T3704 Lasmiditan Lasmiditan, also known as COL-144 and LY573144, is a novel, centrally acting, highly selective 5-HT(1F) receptor agonist (K1=2.21 μM) without vasoconstrictor activity that seemed effective when given as an intravenous infusion in a proof-of-concept migraine study. Lasmiditan showed efficacy in its
T4008 Metergoline Metergoline is a dopamine agonist and serotonin antagonist. It has been used similarly to BROMOCRIPTINE as a dopamine agonist and also for migraine disorder therapy.
T6188 Desvenlafaxine succinate hydrate Desvenlafaxine succinate hydrate is an antidepressant of the serotonin-norepinephrine reuptake inhibitor (SNRI).
T6232 Vilazodone hydrochloride Vilazodone HCl,a partial agonist of 5-HT1A receptors and specific serotonin reuptake inhibitor (SSRI), is utilized in treating of the major depressive disorder.
T6241 Quetiapine Fumarate Quetiapine Fumarate, an atypical antipsychotic, is used in the treatment of bipolar I mania, schizophrenia, bipolar II depression, bipolar I depression.
T6423 BRL-15572 BRL-15572 is a 5-HT1D receptor antagonist with pKi of 7.9, also shows a considerable affinity at 5-HT1A and 5-HT2B receptors, exhibiting 60-fold selectivity over 5-HT1B receptor.
T6426 Buclizine hydrochloride Buclizine HCl is the hydrochloride salt form of buclizine, a piperazine histamine H1 receptor antagonist with primarily antiemetic and antivertigo activities. Buclizine binds to and blocks the histamine H1 receptor, thereby preventing the symptoms that are caused by histamine activity. Buclizine exe
T6488 Epinastine hydrochloride Epinastine is an antihistamine and mast cell stabilizer that is used in eye drops to treat allergic conjunctivitis.
T6493 Escitalopram Oxalate Escitalopram Oxalate is a selective serotonin (5-HT) reuptake inhibitor (SSRI) with Ki of 0.89 nM.
T6562 Latrepirdine Latrepirdine is an orally active,and neuroactive antagonist of multiple drug targets, including histamine receptors, GluR, and 5-HT receptors, used as an antihistamine drug.
T6597 Mosapride Citrate Mosapride Citrate, a gastroprokinetic agent, utilizes as a selective 5HT4 agonist.
T6600 Naftopidil Dihydrochloride Naftopidil DiHCl is a selective 5-HT1A and α1-adrenergic receptor antagonist with IC50 of 0.1 μM and 0.2 μM, respectively.
T6602 Naratriptan Naratriptan Hydrochloride is the hydrochloride salt form of naratriptan, a sulfonamide with selective serotonin (5-HT) 1 receptor agonistic activity and anti-migraine property. Naratriptan hydrochloride binds selectively and with high affinity to the 5-HT1D and 5-HT1B receptor subtypes. Activation o
T6615 Ondansetron Ondansetron is a serotonin 5-HT3 receptor antagonist used mainly as an antiemetic.
T6616 Ondansetron hydrochloride Ondansetron is a serotonin 5-HT3 receptor antagonist, used to prevent nausea and vomiting caused by cancer chemotherapy, and radiation therapy.
T6655 SB269970 hydrochloride SB269970 HCl, a hydrochloride salt form of SB-269970, is a 5-HT7 receptor antagonist (pKi of 8.3) and exhibits >50-fold selectivity against other receptors.
T6656 SB271046 SB271046 is a potent, selective and orally active 5-HT6 receptor antagonist with pKi of 8.9, exhibits 200-fold greater selectivity over other 5-HT receptor subtypes.
T6728 VUF 10166 VUF10166 is a novel, potent and competitive antagonist for 5-HT3A receptor with Ki of 0.04 nM, its affinity at 5-HT3AB receptor is significantly lower.
T6814 Cyproheptadine HCl Cyproheptadine HCl is a hydrochloride salt form of cyproheptadine which is a histamine receptor antagonist.
T6946 Pimavanserin Tartrate Pimavanserin is an effective and specific serotonin 5-HT2A inverse agonist (pIC50: 8.73), used in the therapy of psychosis associated with Parkinson’s disease.
T6958 Prucalopride Succinate Prucalopride is a selective, high affinity 5-HT4 receptor agonist, inhibiting human 5-HT(4a) and 5-HT(4b) receptor with Ki value of 2.5 nM and 8 nM, respectively.
T6959 PRX-08066 Maleic acid PRX-08066 Maleic acid is a selective 5-HT2B receptor antagonist with IC50 of 3.4 nM, prevents the severity of pulmonary arterial hypertension in the MCT rat model. Phase 2.
T6973 RS-127445 RS-127445 is a selective 5-HT2B receptor antagonist with pKi of 9.5 and pIC50 of 10.4, exhibits >1000-fold selectivity against other 5-HT receptors.
T4305 8-OH-Dpat 8-OH-Dpat is a serotonin 1A-receptor agonist that is used experimentally to test the effects of serotonin.
T4266 LY 334370 LY334370 is a selective 5-HT1F receptor agonist with a Ki of 1.6 nM
T4297 Flibanserin Flibanserin is a serotonergic antidepressant used to treat hypoactive sexual desire disorder. Flibanserin has been associated with a low rate of minor serum aminotransferase elevations during treatment but has not been linked to instances of clinically apparent acute liver injury.
T4375 METHIOTHEPIN MALEATE <p>Methiothepin is a 5-HT1, 5-HT6, 5-HT7 serotonin receptor antagonist, which blocks serotonin autoreceptors.</p>
T4118 SB 271046 hydrochloride SB 271046 hydrochloride is selective, orally active 5-HT6 antagonist (pKi values are 9.02-8.92, 6.35, 6.55, 6.27 at 5-HT6, 5-HT1A, 5-HT1D and D3, and 6.05, 5.95, 5.76, 5.73, 5.62, 5.55, 5.41, 5.39, 5.27 and < 4.99 at 5-HT1B, 5-HT1F, α1B, 5-HT2C, 5-HT2A, D2, 5-HT2B, 5-HT7, 5-HT4 and 5-HT1E respectiv
T2226 Pergolide mesylate salt PERGOLIDE MESYLATE is a long-acting dopamine agonist which has been used to treat PARKINSON DISEASE and HYPERPROLACTINEMIA but withdrawn from some markets due to potential for HEART VALVE DISEASES.
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